朱功名 - 河南师范大学 - 化学化工学院

个人简介

2017年毕业于兰州大学，获生物化学与分子生物学博士学位，目前主要从事手性药物和多肽药物的定向合成及关键技术的研究。在Angew. Chem. Int. Ed.，ACS Catal.，Org. Lett.等期刊发表论文15余篇；主持国家自然科学基金1项，省部级基金2两项。教育与研究经历: 2007年9月-2011年6月，河南师范大学，生命科学学院。 2011年9月-2017年6月，兰州大学，生命科学学院，硕博连读，博士。 2017年7月-2018年7月，中山大学，特聘副研究员，药物化学研究。 2018年9月-至今，河南师范大学，化学化工学院。主讲课程：《药理学》，《生物化学》今年来主持及参与的科研项目：国家自然科学青年基金，2019-2021年，主持，资助金额：27.5万元。广东省自然科学基金，2018-2021年，主持，资助金额：10万元。博士后基金面上项目一等资助，2018-2020年，主持，资助金额：8 万元。河南师范大学博士启动经费，2019-2021年，主持，资助金额：8万。参与完成国家自然科学青年基金2项，其中一项被评为优秀；参与重点项目一项，面上项目一项。

研究领域

手性药物和多肽药物的定向合成及关键技术的开发。潜在活性分子的不对称合成新策略研究。活性多肽后修饰及其化学生物学研究。核酸多肽化学生物学研究。

近期论文

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[1] Gongming Zhu#, Guangjun Bao#, Yiping Li, Wangsheng Sun,* Jing Li, Liang Hong,* and Rui Wang*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles. Angew. Chem. Int. Ed. 2017, 56, 5332 –5335. [2] Wangsheng Sun#, Gongming Zhu#, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones. Angew. Chem. Int. Ed.2013, 52, 8633–8637. [3] Gongming Zhu#, Yiping Li#, Guangjun Bao, Wangsheng Sun,* Liwu Huang, Liang Hong,* and Rui Wang*. Catalytic Kinetic Resolution of Spiro-Epoxyoxindoleswith 1 Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel−Crafts Alkylation of 1 Naphthols at the C4 Position.ACS Catal.2018, 8, 1810−1816. [4] Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun, Jing Li, Liang Hong,* and Rui Wang*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones. Org. Lett., 2016, 18, 5288-5291. [5] Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCs，Chem. Commun. 2016, 52, 7882-7885. [6] Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines. Org. Lett. 2013, 15, 4988. [7] Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. “Organo - Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles. Chem. Eur. J. 2012, 18, 13959 – 13963. [8] Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers. Chem. Eur. J. 2012, 18, 6737 – 6741. [9] Wangsheng Sun, Gongming Zhu, Liang Hong,* and Rui Wang*. The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine–Metal Cooperative Catalysis, Chem. Eur. J. 2011, 17, 13958 – 13962. [10] Ming Zhang,1 Wangsheng Sun,1Gongming Zhu, Guangjun Bao, Bangzhi Zhang, Liang Hong,* Min Li,* and Rui Wang*.Enantioselective dearomative arylation of isoquinolines. ACS Catal. 2016, 6, 5290-5294. [11] Zhenhua Zhang, Wangsheng Sun,* Gongming Zhu, Junxian Yang, Ming Zhang, Liang Hong,* and Rui Wang*. Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones. Chem. Commun. 2016, 52, 1377-1380. [12] Wangsheng Sun#,Liang Hong#, Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni,* and Rui Wang*. organocatalytic michael-michael cascade for the enantioselective construction of spirocyclopentane bioxindoles: control of four contiguous stereocenters.Org. Lett.2014, 16, 544-547. [13] Guofeng Li, Guangjun Bao, Gongming Zhu, Yiping Li, Liwu Huang, Wangsheng Sun,* Liang Hong* and Rui Wang*. Regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles. Org. Biomol. Chem., 2018,16, 3655-3661. [14] Bangzhi Zhang, Yiping Li, Guangjun Bao, Gongming Zhu, Jing Li, Lijuan Wang, Bao Zhang, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions. Green Chem. 2017, 19, 2107-2110. [15] Zhixuan Zeng, Xudong Xun, Liwu Huang, Jiecheng Xu, Gongming Zhu, Guofeng Li, Wangsheng Sun,* Liang Hong* and Rui Wang*. Catalyst-free tandem halogenation/semipinacol rearrangement of allyl alcohols with sodium halide in water. Green Chem. 2018, 20, 2477-2480.