Caunt, Christopher - University of Bath - Department of Biology & Biochemistry

个人简介

BSc University of Bristol (1994 - 1997) PhD University of Sheffield (1999 - 2002) Post-doctoral work University of Bristol (2002 - 2010) Lecturer in Cell Biology University of Bath (2010 - present)

研究领域

Our research focuses on mechanisms of receptor signalling through mitogen-activated protein kinase (MAPK) cascades, which control the four basic decisions cells can make: whether to survive, replicate, differentiate or die. Our work is concentrated on the prototypic Raf-MEK-ERK (extracellular signal regulated kinase) pathway, which serves to relay signals from growth factor, integrin and hormone receptors to the cell interior. Appropriate regulation of the ERK cascade is essential for normal embryonic development, and it is deregulated with alarming frequency in human tumours, making ERK pathway components critical drug targets for controlling tumourigenesis.

近期论文

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Caunt, C. J., Kidger, A. M. and Keyse, S. M., 2016. Visualizing and quantitating the spatiotemporal regulation of Ras/ERK signaling by dual-specificity mitogen-activated protein phosphatases (MKPs). In: Pulido, R., ed. Protein Tyrosine Phosphatases. Springer, pp. 197-215. Dayalan Naidu, S., Sutherland, C., Zhang, Y., Risco, A., de la Vega, L., Caunt, C. J., Hastie, C. J., Lamont, D. J., Torrente, L., Chowdhry, S., Benjamin, I. J., Keyse, S. M., Cuenda, A. and Dinkova-Kostova, A. T., 2016. Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases. Molecular and Cellular Biology Garner, K. L., Perrett, R. M., Voliotis, M., Bowsher, C., Pope, G. R., Pham, T., Caunt, C. J., Tsaneva-Atanasova, K. and McArdle, C. A., 2016. Information transfer in gonadotropin-releasing hormone (GnRH) signaling:extracellular signal-regulated kinase (ERK)-mediated feedback loops control hormone sensing. Journal of Biological Chemistry, 291 (5), pp. 2246-2259. Caunt, C. J., Sale, M. J., Smith, P. D. and Cook, S. J., 2015. MEK1 and MEK2 inhibitors and cancer therapy:the long and winding road. Nature Reviews Cancer, 15 (10), 577–592. Rushworth, L. K., Kidger, A. M., Delavaine, L., Stewart, G., Van Schelven, S., Davidson, J., Bryant, C. J., Caddye, E., East, P., Caunt, C. J. and Keyse, S. M., 2014. Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRas Q61L)-driven SerpinB2 expression. Proceedings of the National Academy of Sciences of the United States of America, 111 (51), pp. 18267-18272. Bryant, C. J., Keyse, S. M. and Caunt, C. J., 2014. BRAF inhibitor resistance:are holidays and cocktails the answer? Pigment Cell & Melanoma Research, 27 (5), pp. 693-695. Helsby, M. A., Leader, P. M., Fenn, J. R., Gulsen, T., Bryant, C., Doughton, G., Sharpe, B., Whitley, P., Caunt, C. J., James, K., Pope, A. D., Kelly, D. H. and Chalmers, A. D., 2014. CiteAb:A searchable antibody database that ranks antibodies by the number of times they have been cited. BMC Cell Biology, 15 (1), 6. Perrett, R.M., Fowkes, R.C., Caunt, C.J., Tsaneva-Atanasova, K., Bowsher, C.G. and McArdle, C.A., 2013. Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase c:Feedback, heterogeneity, and gating. Journal of Biological Chemistry, 288 (29), pp. 21001-21014. Pereira Morais, M. P., Marshall, D., Flower, S. E., Caunt, C. J., James, T. D., Williams, R. J., Waterfield, N. R. and Van Den Elsen, J. M. H., 2013. Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis. Scientific Reports, 3, 1437. Caunt, J. and Keyse, S. M., 2013. Dual-specificity MAP kinase phosphatases (MKPs):Shaping the outcome of MAP kinase signalling. FEBS Journal, 280 (2), pp. 489-504. Finch, A. R., Caunt, C. J., Perrett, R. M., Tsaneva-Atanasova, K. and McArdle, C. A., 2012. Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: Indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. Cellular Signalling, 24 (5), pp. 1002-1011. Tsaneva-Atanasova, K., Mina, P., Caunt, C. J., Armstrong, S. P. and McArdle, C. A., 2012. Decoding GnRH neurohormone pulse frequency by convergent signalling modules. Journal of the Royal Society, Interface, 9 (66), pp. 170-182. Caunt, C. J. and McArdle, C. A., 2012. ERK phosphorylation and nuclear accumulation: Insights from single-cell imaging. Biochemical Society Transactions, 40 (1), pp. 224-229. Caunt, C.J., Perett, R.M., Fowkes, R.C. and McArdle, C.A., 2012. Mechanisms of GnRH-induced extracellular signal-regulated kinase nuclear localization. PLoS ONE, 7 (7), e40077. Dukes, J. D., Fish, L., Richardson, J. D., Blaikley, E., Burns, S., Caunt, C. J., Chalmers, A. D. and Whitley, P., 2011. Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells. Molecular Biology of the Cell, 22 (17), pp. 3192-3205. Armstrong, S. P., Caunt, C. J., Finch, A. R. and McArdle, C. A., 2011. Using automated imaging to interrogate gonadotrophin-releasing hormone receptor trafficking and function. Molecular and Cellular Endocrinology, 331 (2), pp. 194-204. Caunt, C. J. and McArdle, C. A., 2010. Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. Journal of Cell Science, 123 (24), pp. 4310-4320. Welsh, G. I., Hale, L. J., Eremina, V., Jeansson, M., Maezawa, Y., Lennon, R., Pons, D. A., Owen, R. J., Satchell, S. C., Miles, M. J., Caunt, C. J., McArdle, C. A., Pavenst?dt, H., Tavaré, J. M., Herzenberg, A. M., Kahn, C. R., Mathieson, P. W., Quaggin, S. E., Saleem, M. A. and Coward, R. J. M., 2010. Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metabolism, 12 (4), pp. 329-340. Armstrong, S. P., Caunt, C. J., Fowkes, R. C., Tsaneva-Atanasova, K. and McArdle, C. A., 2010. Pulsatile and sustained Gonadotropin-releasing Hormone (GnRH) receptor signaling: Does the ERK signaling pathway decode GnRH pulse frequencey? Journal of Biological Chemistry, 285 (32), pp. 24360-24371. Finch, A. R., Sedgley, K. R., Armstrong, S. P., Caunt, C. J. and McArdle, C. A., 2010. Trafficking and signalling of gonadotrophin-releasing hormone receptors:an automated imaging approach. British Journal of Pharmacology, 159 (4), pp. 751-760.