Tosh, David - University of Bath - Department of Biology & Biochemistry

研究领域

My lab is mainly interested in the general phenomenon of cellular reprogramming. Reprogramming is defined as the conversion of one cell type (including stem cells) to another. We have developed a number of models for the reprogramming of pancreatic cells to liver cells and the reverse, liver to pancreas transformation and for the conversion of oesophagus to intestine (see selected publications).

近期论文

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Chien, C. Y., Lee, H. S., Cho, C. H. H., Lin, K. I., Tosh, D., Wu, R. R., Mao, W. Y. and Shen, C. N., 2016. Forthcoming. Maternal vitamin A deficiency during pregnancy affects vascularized islet development. Journal of Nutritional Biochemistry, 36, pp. 51-59. Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., Metcalfe, P., Kitteringham, N. R., Baxter, M., Harrison, S., Hanley, N. A., Burke, Z. D., Storm, M. P., Welham, M. J., Tosh, D., Küppers-Munther, B., Edsbagge, J., Starkey Lewis, P. J., Bonner, F., Harpur, E., Sidaway, J., Bowes, J., Fenwick, S. W., Malik, H., Goldring, C. E. P. and Kevin Park, B., 2015. MicroRNA-122:A novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. Toxicological Sciences, 144 (1), pp. 173-185. Sangan, C. B., Jover, R., Heimberg, H. and Tosh, D., 2015. In vitro reprogramming of pancreatic alpha cells towards a beta cell phenotype following ectopic HNF4α expression. Molecular and Cellular Endocrinology, 399, pp. 50-59. Carter, E., Miron-Buchacra, G., Goldoni, S., Danahay, H., Westwick, J., Watson, M. L., Tosh, D. and Ward, S. G., 2014. Phosphoinositide 3-kinase alpha-dependent regulation of branching morphogenesis in murine embryonic lung:Evidence for a role in determining morphogenic properties of FGF7. PLoS ONE, 9 (12), e113555. O'Neill, K.E., Thowfeequ, S., Li, W.-C., Eberhard, D., Dutton, J.R., Tosh, D. and Slack, J.M.W., 2014. Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα. Cellular Reprogramming, 16 (5), pp. 314-323. Wung, N., Acott, S. M., Tosh, D. and Ellis, M. J., 2014. Hollow fibre membrane bioreactors for tissue engineering applications. Biotechnology Letters, 36 (12), pp. 2357-2366. Ali Khan, M., Wood, P. J., Lamb-Guhren, N. M., Caggiano, L., Kociok-K?hn, G., Tosh, D. and Lewis, S. E., 2014. The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity. Bioorganic & Medicinal Chemistry Letters, 24 (13), pp. 2815-2819. Corbett, J.L. and Tosh, D., 2014. Conversion of one cell type into another:Implications for understanding organ development, pathogenesis of cancer and generating cells for therapy. Biochemical Society Transactions, 42 (3), pp. 609-616. Storm, M.P., Kumpfmueller, B., Bone, H.K., Buchholz, M., Sanchez Ripoll, Y., Chaudhuri, J.B., Niwa, H., Tosh, D. and Welham, M.J., 2014. Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells. PLoS ONE, 9 (3). Tosh, D. and Horb, M. E., 2013. How cells change their phenotype. In: Lanza, R. and Atala, A., eds. Essentials of Stem Cell Biology (3rd ed.). San Diego, U. S. A.: Elsevier, pp. 107-117. Gibson, M. K., Dhaliwal, A. S., Clemons, N. J., Phillips, W. A., Dvorak, K., Tong, D., Law, S., Pirchi, E. D., Rasanen, J., Krasna, M. J., Parikh, K., Krishnadath, K. K., Griffiths, L., Colleypriest, B. J., Farrant, J. M., Tosh, D., Das, K. M. and Bajpai, M., 2013. Barrett's esophagus:Cancer and molecular biology. Annals of the New York Academy of Sciences, 1300 (1), pp. 296-314. Carter, E., Lau, C. Y., Tosh, D., Ward, S. G. and Mrsny, R. J., 2013. Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro:Implications for continued therapeutic use. European Journal of Pharmaceutics and Biopharmaceutics, 85 (1), pp. 12-19. Perán, M., Marchal, J. A., García, M. A., Kenyon, J. and Tosh, D., 2013. In vitro treatment of carcinoma cell lines with pancreatic (pro)enzymes suppresses the EMT programme and promotes cell differentiation. Cellular Oncology, 36 (4), pp. 289-301. Burke, Z. D. and Tosh, D., 2012. Barrett's metaplasia as a paradigm for understanding the development of cancer. Current Opinion in Genetics & Development, 22 (5), pp. 494-499. Burke, Z. D., Miron-Buchacra, G. and Tosh, D., 2012. Cellular Reprogramming During Mouse Development. In: Kubiak, J. Z., ed. Mouse Development. Berlin: Springer, pp. 291-302. Tosh, D. and Horb, M. E., 2012. How cells change their phenotype. In: Atala, A. and Lanza, R., eds. Handbook of Stem Cells. Oxford, U. K.: Elsevier, pp. 95-100. Burke, Z. D. and Tosh, D., 2012. Ontogenesis of Hepatic and Pancreatic Stem Cells. Stem Cell Reviews and Reports, 8 (2), pp. 586-596. Bone, H. K., Nelson, A. S., Goldring, C. E., Tosh, D. and Welham, M. J., 2011. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. Journal of Cell Science, 124 (12), pp. 1992-2000. Peran, M., Sanchez-Ferrero, A., Tosh, D., Marchal, J. A., Lopez, E., Alvarez, P., Boulaiz, H., Rodriguez-Serrano, F. and Aranega, A., 2011. Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells. Cytotherapy, 13 (2), pp. 193-200. Sangan, C. B. and Tosh, D., 2010. Hepatic progenitor cells. Cell and Tissue Research, 342 (2), pp. 131-137.