Zheng, Qinguo - Aston University - School of Life & Health Sciences, Pharmacy

个人简介

1998-date School of Life & Health Sciences, Aston University. 1997-98 Post-doctoral Research Fellow, MRC Toxicology Unit, University of Leicester. 1995-96 Post-doctoral Research Assistant, UCL. 1991-95 PhD Student/Research Assistant, UCL. 1990-91 Research Assistant, UCL. 1987-90 Zhejiang University, Zhejiang, China. 1984-87 Zhejiang University, Zhejiang, China, MSc in organic chemistry. 1978-82. Zhejiang University, Zhejiang, China, BSc in chemistry.

研究领域

Development of novel methodologies for synthesis of modified nucleic acids and peptide nucleic acids, and their use as potential antisense therapeutic agents. Oxidative DNA damage. Therapeutic natural products and their derivatives. Development of novel reagents for organic synthesis.

近期论文

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Y.– Z. Xu, Q. Zheng and P. F. Swann Tetrahedron Letters 32 2817-2820 (1991) Simple synthesis of 4-thiothymidine, 4-thiouridine and 6-thio-2’-deoxyguanosine. Y. – Z. Xu, Q. Zheng and P. F. Swann Tetrahedron Letters 33 5837-5840 (1992) Synthesis and duplex stability of oligodeoxynucleotides containing 6-mercaptopurine. Y. – Z. Xu, Q. Zheng and P. F. Swann Tetrahedron 48 1729-1742 (1992) Synthesis by post-synthetic substitution of oligomers containing guanine modified at the 6-position with S-, N-, O-derivatives. Y. – Z. Xu, Q. Zheng and P. F. Swann Journal of Organic Chemistry 57 3839-3845 (1992) Synthesis of DNA containing modified bases by post-synthetic substitution: Synthesis of oligomers containing 4-substituted thymine: O4-alkylthymine, 5-methylcytosine, N4-dimethylamino-5-methylcytosine and 4-thiothymine. Y. – Z. Xu, Q. Zheng and P. F. Swann Nucleosides & Nucleosides 14 929-932 (1995) Preparation of oligodeoxynucleotides containing 6-methylthiopurine residues by chemical synthesis or specific methylation Q. Zheng, Y. – Z. Xu and P. F. Swann Nucleosides & Nucleosides 14 939-942 (1995) An improved post-synthetic substitution approach for synthesis of DNA containing labile 4-substituted thymine. P. F. Swann, T. R. Waters, D. C. Moulton, Y.- Z. Xu, Q. Zheng, M. Edwards and R. Mace Science 273 1109-1111 (1996) Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Y.– Z. Xu, Q. Zheng and P. F. Swann Nucleosides & Nucleosides 16 1559-1562 (1997) Site-specific introduction of functional groups onto bases in synthetic oligonucleotides for biological applications. Q. Zheng, Y.– Z. Xu and P. F. Swann Nucleosides & Nucleosides 16 1799-1803 (1997) Photochemical cross-linking of l–Cro repressor to operator DNA specifically substituted with 4-thiothymine or 6-thioquanine M. D. Evans, M. S. Cooke, I. D. Podmore, Q. Zheng, K. E. Herbert, and J. Lunec Biochemical and Biophysical Research Communications 259 374-378 (1999) Discrepancies in the measurement of UVC-induced 8-oxo-2’-deoxyguanosine: Implication of the analysis of oxidative DNA damage. J. Lunec, K.E. Herbert, G.D.D. Jones, L. Dickinson, M. Evans, N. Mistry, D.Chauhan, G. Capper and Q. Zheng Free Radical Research, 33: 27-31 (2000) Development of a quality control material for the measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine, an In Vivo marker of oxidative stress, and comparison of results from different laboratories. L. Wang, Z.-C. Chen, Q. Zheng Chinese Journal of Chemistry221457-1459 (2002) Hyperiodine in synthesis 64: Synthesis of diaryl selenides and alkyl aryl selenides by palladium-catalyzed arylation of areneselenyl or alkaneselenyl magnesium bromide with diaryliodonium salt. D.-P. Cheng, Z.-C. Chen, Q. Zheng J. Chem. Res. 2002: 624-625(2002) Hypervalent iodine in synthesis 91: A mild and efficient method for the halogenation of 6-methyluracil derivatives. Y.-Y. Xie, Z.-C. Chen, Q. Zheng J. Chem. Res. 2002: 618-619(2002) Organic reactions in ionic liquids: a-tosyloxylation of ketones. Y-Y Xie, Z-C Chen, Q Zheng Synthesis-Stuttgart 11 1505 -1508 (2002) Organic reactions in ionic liquids: ionic-liquid-accelerated cyclocondensation of a tosyloxyketones with 2-aminopyridine. C. Su, Z.-C. Chen, Q. Zheng Synthetic Communications 33, 2817-2822 (2003) Organic reactions in ionic liquids: alkylation of Meldrum acid. D-P Cheng, Z.-C. Chen, Q. Zheng Synthetic Communications 33, 2671-2676 (2003) Hypervalent iodine in synthesis 90: A mild and efficient method for the iodination of pyrazoles. Z Liu, Z-C Chen, Q, Zheng Org Lett 5 3321-3323 (2003) Mild oxidation of alcohols with O-iodoxybenzoic acid (IBX) in ionic liquid 1-butyl-3-methyl-imidazolium chloride and water. D-H. Yang, Z-C. Chen, S-Y Chen, Q Zheng Synthesis-Stuttgart 12 1891-1894 (2003) Organic reactions in ionic liquids; Ionic liquid-accelerated three-component reaction: A rapid one-pot synthesis of 3-alkyl-5-[(Z)-arylmethylidene]-1,3-thiazolidine-2,4-diones. D-H. Yang, Z-C. Chen & Q. Zheng J. Chem. Res. 2003 330-331 (2003) A convenient synthesis of 5-benzylidenethiazolidine-2, 4-diones under microwave irradiation without solvent.