Pitt, Andrew - Aston University - School of Life & Health Sciences, Pharmacy

个人简介

2012 - date Professor of Pharmaceutical Chemistry and Chemical Biology, Aston University 2009 - 2011 Reader, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences 2005 - 2011 Director, RASOR Interdisciplinary Research Collaboration in Proteomic Technologies 2005 - 2011 Director, Doctoral Training Centre in Proteomics 2005 - 2011 Director, Sir Henry Wellcome Functional Genomics Facility 2005 - 2009 Senior Lecturer in Proteomics, Division of Integrative and Systems Biology, Institute of Biomedical and Life Sciences 2002 - 2005 Deputy Director and Head of Proteomics, SHWFGF, University of Glasgow 1993 - 2002 Lecturer, Department of Pure and Applied Chemistry, University of Strathclyde. 1990 - 1993 Research Fellow, St. Catharine's College, Cambridge. 1989 - 1992 Schering Fellow in Bioorganic Chemistry, Department of Chemistry, University of Cambridge. 1988 - 1989 Research Assistant, Oxford University. 1985 - 1988 D.Phil., Biological Chemistry, Oxford University. 1982 - 1985 B.Sc, Chemistry, University of Bristol

研究领域

My research has always been about understanding how biology works at the molecular level, using a multidisciplinary approach combining chemistry, biology, physics and engineering. We are developing techniques and technologies and applying them to help to understand complex biological problems, in collaboration with many talented research groups. Many of the techniques and technologies we are developing also have a much broader applications, and we have research in many areas including drug discovery and analysis, chemical biology, biomarker discovery, biotechnology, biocatalysis, and systems and synthetic biology. One of our aims is to generate a better understanding, diagnosis, stratification, and treatment of disease, from identifying new targets for drugs, through to monitoring the therapeutic effect of drugs in the clinic. At the cellular level we are interested in how the complex pathways involved in intracellular signalling are regulated, the role of redox chemistry in signalling and cellular damage, and understanding the molecular targets of drugs.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Verrastro, I, Tveen-Jensen, K, Woscholski, R, Spickett, CM & Pitt, AR 2016, 'Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins' Free Radical Biology and Medicine, vol. 90, pp. 24-34,10.1016/j.freeradbiomed.2015.11.004 Spickett, CM, Verrastro, I & Pitt, AR 2015, 'Uncovering changes in the redox protein interactome of PTEN' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, OP15, pp. S9,10.1016/j.freeradbiomed.2015.07.042 Thakker, A, Spickett, C & Pitt, A 2015, 'Optimisation of chromatographic separation of oxidised phospholipids and detection with targeted approaches provides greater coverage of the oxidised lipidome' Free Radical Biology and Medicine, vol. 86, no. Suppl.1, PP18, pp. S25,10.1016/j.freeradbiomed.2015.07.093 Spickett, CM & Pitt, AR 2015, 'Oxidiative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology' Antioxidants and Redox Signaling, vol. 22, no. 18, pp. 1646-1666,10.1089/ars.2014.6098 Spickett, CM & Pitt, AR 2015, ' Oxidative lipidomics coming of age: advances in analysis of oxidized phospholipids in physiology and pathology ' Antioxidants and redox signaling , vol 22, no. 18, pp. 1646-1666., 10.1089/ars.2014.6098 Tveen Jensen, K, Gesellchen, F, Wilson, R, Spickett, C, Cooper, JM & Pitt, A 2015, 'Interfacing low-energy SAW nebulization with liquid chromatography-mass spectrometry for the analysis of biological samples' Scientific Reports, vol. 5, 9736,10.1038/srep09736 Verrastro, I, Pasha, S, Jensen, KT, Pitt, AR & Spickett, CM 2015, 'Mass spectrometry-based methods for identifying oxidized proteins in disease: advances and challenges' Biomolecules, vol. 5, no. 2, pp. 378-411,10.3390/biom5020378 Reis, A, Rudnitskaya, A, Chariyavilaskul, P, Dhaun, N, Melville, V, Goddard, J, Webb, DJ, Pitt, AR & Spickett, CM 2015, 'Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease' Journal of Lipid Research, vol. 56, no. 2, pp. 413-422,10.1194/jlr.M055624 Rezende Valim, L, Davies, JA, Tveen Jensen, K, Guo, R, Willison, KR, Spickett, CM, Pitt, AR & Klug, DR 2014, 'Identification and relative quantification of tyrosine nitration in a model peptide using two-dimensional infrared spectroscopy' Journal of Physical Chemistry: Part B, vol. 118, no. 45, pp. 12855-12864,10.1021/jp509053q Sandison, ME, Tveen Jensen, K, Gesellchen, F, Cooper, JM & Pitt, AR 2014, 'Magnetite-doped polydimethylsiloxane (PDMS) for phosphopeptide enrichment' Analyst, vol. 139, no. 19, pp. 4974-4981,10.1039/C4AN00750F Tveen-Jensen, K, Reis, A, Spickett, CM & Pitt, AR 2014, 'Targeted mass spectrometry methods for detecting oxidative post-translational modifications' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P93, pp. S52-S53,10.1016/j.freeradbiomed.2014.10.825 Pasha, S, Tveen Jensen, K, Pitt, AR & Spickett, CM 2014, 'Detection and quantification of protein oxidation in sarcopenic models: a mass spectrometry study' Free Radical Biology and Medicine, vol. 75, no. Suppl.1, P68, pp. S44,10.1016/j.freeradbiomed.2014.10.800 Jiwaji, M, Sandison, ME, Reboud, J, Stevenson, R, Daly, R, Barkess, G, Faulds, K, Kolch, W, Graham, D, Girolami, MA, Cooper, JM & Pitt, A 2014, 'Quantification of functionalised gold nanoparticle-targeted knockdown of gene expression in HeLa cells' PLoS ONE, vol. 9, no. 6, e99458,10.1371/journal.pone.0099458 Maciel, E, Neves, BM, Santinha, D, Reis, A, Domingues, P, Cruz, MT, Pitt, AR, Spickett, CM & Domingues, MRM 2014, 'Detection of phosphatidylserine with a modified polar head group in human keratinocytes exposed to the radical generator AAPH' Archives of Biochemistry and Biophysics, vol. 548, pp. 38–45,10.1016/j.abb.2014.02.002 Robaszkiewicz, A, Bartosz, G, Pitt, AR, Thakker, A, Armstrong, RA, Spickett, CM & Soszynski, M 2014, 'HOCl-modified phosphatidylcholines induce apoptosis and redox imbalance in HUVEC-ST cells' Archives of Biochemistry and Biophysics, vol. 548, pp. 1-10,10.1016/j.abb.2014.02.013 Calimport, S, Pitt, AR & Spickett, CM 2013, 'Residue-specific investigation of the relationship between oxidation and activity of a dual specificity phosphatase by mass spectrometry' Free Radical Biology and Medicine, vol. 65, no. Suppl.2, PSS110, pp. S57,10.1016/j.freeradbiomed.2013.10.527 Tveen Jensen, K, Reis, A, Mouls, L, Pitt, AR & Spickett, CM 2013, 'Reporter ion-based mass spectrometry approaches for the detection of non-enzymatic protein modifications in biological samples' Journal of Proteomics, vol. 92, pp. 71-79,10.1016/j.jprot.2013.03.033 Spickett, CM, Tveen-jensen, K, Reis, A & Pitt, AR 2013, 'Protein modification and phospholipid oxidation' Free Radical Biology and Medicine, vol. 65, no. Suppl.1, pp. S15,10.1016/j.freeradbiomed.2013.08.140 Reis, A, Rudnitskaya, A, Blackburn, GJ, Fauzi, NM, Pitt, AR & Spickett, CM 2013, 'A comparison of five lipid extraction solvent systems for lipidomic studies of human LDL' Journal of Lipid Research, vol. 54, no. 7, pp. 1812-1824,10.1194/jlr.M034330 Spickett, CM, Reis, A & Pitt, AR 2013, 'Use of narrow mass-window, high-resolution extracted product ion chromatograms for the sensitive and selective identification of protein modifications' Analytical Chemistry, vol. 85, no. 9, pp. 4621-4627,10.1021/ac400131f