沙永强 - 华侨大学 - 生物医学学院

个人简介

教育工作经历： 2018.04~至今，华侨大学，讲师 2010.09~2017.12，重庆大学，博士 2008.08~2008.12，山东鲁南制药有限公司，科研人员 2004.09~2008.07，西北大学，学士主持或参与的科研项目： 1. 国家自然科学基金青年项目，力生长因子E肽在严重低氧条件下调控前交叉韧带损伤后修复的机理研究，2019~2021，25万，在研，主持； 2. 华侨大学科研启动经费项目--引进人才类，低氧条件下MGF E肽调控ACL损伤后的修复的机制研究，2018~2020，12万，在研，主持； 3. 国家自然科学基金面上项目，悬浮力学状态对乳腺肿瘤细胞存活和转移的调控及其力学生物学机制，2017~2019，68万，在研，参与； 4. 国家自然科学基金面上项目，低强度超声联合诱导性多潜能干细胞促进损伤周围神经修复的研究，2012~2014，70万，已结题，参与。参与编写著作： [1] 参编，组织修复生物力学(精)/生物力学研究前沿系列，上海交通大学出版社，第一版，ISBN: 9787313184979.

研究领域

胚胎发育；生物力学与组织再生；肿瘤的发生与生物治疗。

近期论文

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[1] Sha Y, Yang L, Lv Y*. MGF E peptide improves ACL repair by inhibiting hypoxia-induced cell apoptosis and accelerating angiogenesis. J Cell Physiol. 2019. 234: 8846-8861. [2] Sha Y, Xu Z, Yang L, Lv Y*. ERK1/2 and Akt phosphorylation were essential for MGF E peptide regulating cell morphology and mobility but not proangiogenic capacity of BMSCs under severe hypoxia. Cell Biochem Funct. 2018. 36:155-165. [3] Sha Y, Afandi R, Zhang B, Yang L, Lv Y*. MGF E peptide pretreatment improves collagen synthesis and cell proliferation of injured human ACL fibroblasts via MEK-ERK1/2 signaling pathway. Growth Factors. 2017. 35:29-38. [4] Sha Y, Lv Y*, Xu Z, Yang L, Hao X, Afandi R. MGF E peptide pretreatment improves the proliferation and osteogenic differentiation of BMSCs via MEK-ERK1/2 and PI3K-Akt pathway under severe hypoxia. Life Sci. 2017. 189:52-62. [5] Y Sha, Y Lv*. Effects of MGF E peptide pretreatment on the cell morphology, mobility, proliferation and osteogenic differentiation of BMSCs under severe hypoxia. FEBS J. 2017. 284 (Special Issue, meeting abstract): 126-126. [6] 沙永强, 杨力, 吕永钢*.力生长因子E肽对前交叉韧带成纤维细胞活力、迁移和侵袭的影响. 医用生物力学, 2016. 31:227-234. [7] Xu K, Sha Y, Wang S, Chi Q, Liu Y, Wang C, Yang L. Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. Cell Prolif. 2019. 52(5): e12666. [8] Wang C, Al-Ani MK, Sha Y, Chi Q, Dong N, Yang L, Xu K. Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis. Int J Biol Sci. 2019. 15: 229-238. [9] He J, Dong L, Xu K, Qian Y, Wang C, Sha Y, et al. Mechano growth factor E peptide inhibits invasion of melanoma cells and up-regulates CHOP expression via endoplasmic reticulum stress. Biotechnol Lett. 2018. 40:205-213. [10] Xu K, Sun Y, Mohanad KA, Wang C, Sha Y, et al. Synergistic promoting effects of bone morphogenetic protein 12/connective tissue growth factor on functional differentiation of tendon derived stem cells and patellar tendon window defect regeneration. J Biomech. 2017. 66:95-102. [11] Lv Y*, Nan P, Chen G, Sha Y, Xia B, Yang L. In vivo repair of rat transected sciatic nerve by low-intensity pulsed ultrasound and induced pluripotent stem cells-derived neural crest stem cells. Biotechnol Lett. 2015. 37:2497-506. [12] 余璨,沙永强,郭盼,陈义梅,等.力生长因子对软组织修复调控作用的研究.生物医学工程学杂志.2015. 32:235-9. [13] Lv Y*, Hao X, Sha Y, Yang L. Pretreatment with mechano-growth factor E peptide protects bone marrow mesenchymal cells against damage by fluid shear stress. Biotechnol Lett. 2014. 36:2559-69. [14] Lv Y*, Zhao P, Chen G, Sha Y, Yang L. Effects of low-intensity pulsed ultrasound on cell viability, proliferation and neural differentiation of induced pluripotent stem cells-derived neural crest stem cells. Biotechnol Lett. 2013. 35:2201-2212.