陈凌 - 华侨大学 - 生物医学学院

个人简介

中国科学院广州生物医药与健康研究院首任创始院长（2004-2008）、研究员、博士生导师，国家杰出青年科学基金（外籍）获得者。曾先后担任了葛兰素史克公司（GlaxoSmithKline）全球研发副总裁、法国赛诺菲公司(Sanofi)全球研发副总裁。2013年起担任呼吸疾病国家重点实验室研究员，中国科学院广州生物医药与健康研究院特聘研究员，广州医科大学教授，华侨大学教授。研究工作与科研兴趣涉及生物医药的前沿领域，包括传染病、代谢疾病、癌症等疾病的药物开发和疫苗研究。在国际一流科学期刊Nature, Nature communication，Journal of Clinical Investigation,Advanced science, Journal of Virology, Vaccine, Journal of Biology Chemistry, Cancer Research等发表了70多篇论文。在过去五年 (2015-现在)作为通讯作者累计影响因子超过150。申请了多项国内/国际专利。 1979-1985就读于上海第一医学院医学系，1984年考取赴美留学CUSBEA项目。1985-1991年在美国印第安那大学（Indiana University）医学院生物化学和分子生物学系主攻生物化学和分子生物学，获博士学位。1992-1993年在美国哈佛大学医学院(Harvard Medical School)及Dana-Farber癌症研究所从事博士后研究。1994-1996年在哈佛大学医学院担任讲师(Instructor)、1997-2001年在美国默克（Merck）制药公司担任资深研究员（Senior Research Fellow）。主要成果包括默克实验室的艾滋病疫苗的第一发明人, 该疫苗曾被专家评为最具希望成功的艾滋病疫苗,并进入大规模临床II期试验。共获得艾滋病疫苗，癌症的分子化疗，人类乳突状瘤病毒和子宫颈癌疫苗等约二十多项国际专利发明。研究工作涉及生物医药的前沿领域，包括癌症、传染病等疾病的药物开发和疫苗研究。在国际一流科学期刊Nature,Nature Communications, Journal of Clinical Investigation, Cancer Research, Journal of Virology, Vaccine等发表了一百余篇具有应用及转化医学价值的论文。项目情况：福建省百人计划华侨大学项目启动经费

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Qing Yang#, Fengling Feng#, Pingchao Li#, Enxiang Pan, Chunxiu Wu, Yizi He, Fan Zhang, Jin Zhao, Ruiting Li, Liqiang Feng, Fengyu Hu, Linghua Li, Huachun Zou, Weiping Cai, Thomas Lehner,* Caijun Sun,* and Ling Chen*.Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. Advanced Science, 2019. 1900319:10. Xuefeng Niu, Lingzhai Zhao, Linbing Qu, Zhipeng Yao, Fan Zhang, Qihong Yan, Shengnan Zhang, Renshan Liang, Peihai Chen, Jia Luo, Wei Xu, Huibin Lv, Xinglong Liu,Hui Lei, Changhua Yi, Pingchao Li, Qian Wang, Yang Wang, Lei Yu, Xiaoyan Zhang, L. Aubrey Bryan, Edgar Davidson, j. Benjamin Doranz, Liqiang Feng, Weiqi Pan, Fuchun Zhang & Ling Chen (2019) Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model, Emerging Microbes & Infections, 8:1, 749-759, DOI: 10.1080/22221751.2019.1614885. Feng F, Zhao J, Li P, Li R, Chen L, Sun C. Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+ Cells. Viruses. 2019;11(2):154. Published 2019 Feb 13. doi:10.3390_x005f711020154. Xinli Zhang,Linbing Qu,Ling Chen，Chen Chen.Improvement of cardiomyocyte function by in vivo hexarelin treatment in streptozotocin-induced diabetic rats.Physiol Rep. 2018 Feb;6(4). doi: 10.14814/phy2.13612. Pingchao Li,Fengling Feng,Enxiang Pan, Xiaozhen Fan,Qing Yang,Min Guan,Ling Chen,Caijun Sun.Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection.Virology. 2018 Jun;519:86-98. doi: 10.1016/j.virol.2018.04.005. Epub 2018 Apr 19. Ying Feng,Xikui Sun,Xianmiao Ye,Yupeng Feng,Jinlin Wang,Xuehua Zheng,Xinglong Liu,Changhua Yi,Mingli Hao,Qian Wang,Feng Li,Wei Xu,Liang Li,Chufang Li,Rong Zhou,Ling Chen,Liqiang Feng.Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity.Virology. 2018 May;518:272-283. doi: 10.1016/j.virol.2018.03.002. Epub 2018 Mar 15. Weiqi Pan，Haojun Xie，Xiaobo Li，Wenda Guan，Peihai Chen，Beiwu Zhang，Mincong Zhang，Ji Dong，Qian Wang，Zhixia Li，Shufen Li，Zifeng Yang，Chufang Li，Nanshan Zhong，Jicheng Huang，Ling Chen.Patient-derived avian influenza A (H5N6) virus is highly pathogenic in mice but can be effectively treated by anti-influenza polyclonal antibodies.Emerg Microbes Infect. 2018 Jun 13;7(1):107. doi: 10.1038/s41426-018-0113-2. Yupeng Feng，Chufang Li，Peiyu Hu，Qian Wang，Xuehua Zheng，Yongkun Zhao，Yi Shi，Songtao Yang，Changhua Yi，Ying Feng，ChunxiuWu，Linbing Qu，WeiXu，YaoLi，CaijunSun，FuGerogeGao，XianzhuXia，Liqiang Feng，Ling Chen.An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques.Emerg Microbes Infect. 2018 Jun 6;7(1):101. doi: 10.1038/s41426-018-0102-5. Pan E, Feng F, Li P, Yang Q, Ma X, Wu C, Zhao J, Yan H, Chen R, Chen L, Sun C. Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys. Front Immunol. 2018 Oct 23;9:2415 Tongjin Wu, Feng Ma, Xiuchang Ma, Weizhe Jia, Pan Enxiang, Genhong Cheng, Ling Chen,Caijun Sun. Regulating innate and adaptive immunity for controlling SIV infection by25-hydroxycholesterol. Front. Immunol. 2018 Nov 21;9:2686 X Liu, L Qu, X Ye, C Yi, X Zheng, M Hao, W Su, Z Yao, P Chen, S Zhang, Y Feng, Q Wang, Q Yan, P Li, H Li, L Feng and L. Chen, ' Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein', npj Vaccines, 29 (2018). Y Feng, C Li, P Hu, Q Wang, X Zheng, Y Zhao, Y Shi, S Yang, C Yi, Y Feng, C Wu, L Qu, W Xu, Y Li, C Sun, F Gao, X Xia, L Feng and L. Chen, ' An adenovirus serotype 2 vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques', Emerg Microbes Infect, doi:10.1038/s41426-018-0102-5 F. Li, P. R. Wang, L. B. Qu, C. H. Yi, F. C. Zhang, X. P. Tang, L. G. Zhang, and L. Chen, ' Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection', Virology, Apr 19;519:86-98. P Li, F Feng, E Pan, X Fan, Q Yang, M Guan, L Chen*, C Sun*, 'Axl Is Not Essential for Zika Virus Infection in the Mouse Brain', Emerg Microbes Infect, 6 (2017), e16. Feng Y, Sun X, Ye X, Feng Y, Wang J, Zheng X, Liu X, Yi C, Hao M, Wang Q, Li F, Xu W5, Li L, Li C, Zhou R, Chen L, Feng L., ' Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity.', Virology, 2018. Mar 15;518:272-283. Zhang Y, Feng Y, Li L, Ye X, Wang J, Wang Q, Li P, Li N, Zheng X, Gao X, Li C, Li F, Sun B, Lai K, Su Z, Zhong N, Chen L, Feng L., ' Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma.', JOURNAL OF MOLECULAR MEDICINE-JMM, 2018, Apr;96(3-4):249-263. Xie H, Li C, Zhang M, Zhong N, Chen L. ' Association between IRGM polymorphisms and tuberculosis risk: A meta-analysis.', Medicine (Baltimore). ,2017. Oct;96(43):e8189. Yang, Q ; Ding, YY ; Feng, FL ; Pan, EX; Fan, XZ; Ma, XC ; Chen, L ; Zhao, JL; Sun, CJ ' "Structure-optimized dihydropyranoindole derivative GIBH-LRA002 potentially reactivated viral latency in primary CD4+ T lymphocytes of chronic HIV-1 patients".', MEDCHEMCOMM, 2017, 8(9): 1806-1809. F. Li, P. R. Wang, L. B. Qu, C. H. Yi, F. C. Zhang, X. P. Tang, L. G. Zhang, and L. Chen, 'Axl Is Not Essential for Zika Virus Infection in the Mouse Brain', Emerg Microbes Infect, 6 (2017), e16. X. Zheng, X. Rong, Y. Feng, X. Sun, L. Li, Q. Wang, M. Wang, W. Liu, C. Li, Y. Yang, R. Zhou, J. Lu, L. Feng, and L. Chen, 'Seroprevalence of Neutralizing Antibodies against Adenovirus Type 14 and 55 in Healthy Adults in Southern China', Emerg Microbes Infect, 6 (2017), e43. Q. Zhang, M. Gui, X. Niu, S. He, R. Wang, Y. Feng, A. Kroeker, Y. Zuo, H. Wang, Y. Wang, J. Li, C. Li, Y. Shi, X. Shi, G. F. Gao, Y. Xiang, X. Qiu, L. Chen, and L. Zhang, 'Potent Neutralizing Monoclonal Antibodies against Ebola Virus Infection', Sci Rep, 6 (2016), 25856. X. Wang, C. Sun, P. Li, T. Wu, H. Zhou, D. Yang, Y. Liu, X. Ma, Z. Song, Q. Nian, L. Feng, C. Qin, L. Chen, and R. Tang, 'Vaccine Engineering with Dual-Functional Mineral Shell: A Promising Strategy to Overcome Preexisting Immunity', Adv Mater, 28 (2016), 694-700. Y. Ren, C. Li, L. Feng, W. Pan, L. Li, Q. Wang, J. Li, N. Li, L. Han, X. Zheng, X. Niu, C. Sun, and L. Chen, 'Proton Channel Activity of Influenza a Virus Matrix Protein 2 Contributes to Autophagy Arrest', J Virol, 90 (2015), 591-8. H. Zhi, L. Qu, F. Wu, L. Chen, and J. Tao, 'Group Iie Secretory Phospholipase A2 Regulates Lipolysis in Adipocytes', Obesity (Silver Spring), 23 (2015), 760-8. Y. Zhang, L. Feng, L. Li, D. Wang, C. Li, C. Sun, P. Li, X. Zheng, Y. Liu, W. Yang, X. Niu, N. Zhong, and L. Chen, 'Effects of the Fusion Design and Immunization Route on the Immunogenicity of Ag85a-Mtb32 in Adenoviral Vectored Tuberculosis Vaccine', Hum Vaccin Immunother, 11 (2015), 1803-13. W. Pan, L. Han, Z. Dong, X. Niu, Z. Li, L. Bao, C. Li, Q. Luo, Z. Yang, X. Li, J. Huang, L. Feng, C. Qin, N. Zhong, and L. Chen, 'Induction of Neutralizing Antibodies to Influenza a Virus H7n9 by Inactivated Whole Virus in Mice and Nonhuman Primates', Antiviral Res, 107 (2014), 1-5. W. Pan, Z. Dong, F. Li, W. Meng, L. Feng, X. Niu, C. Li, Q. Luo, Z. Li, C. Sun, and L. Chen, 'Visualizing Influenza Virus Infection in Living Mice', Nat Commun, 4 (2013), 2369. W. Meng, W. Pan, A. J. Zhang, Z. Li, G. Wei, L. Feng, Z. Dong, C. Li, X. Hu, C. Sun, Q. Luo, K. Y. Yuen, N. Zhong, and L. Chen, 'Rapid Generation of Human-Like Neutralizing Monoclonal Antibodies in Urgent Preparedness for Influenza Pandemics and Virulent Infectious Diseases', PLoS One, 8 (2013), e66276. Lijun Xiao, Dimin Wang, Caijun Sun, Pingchao Li, Yi Jin, Liqiang Feng, and Ling Chen, 'Enhancement of Siv-Specific Cell Mediated Immune Responses by Co-Administration of Soluble Pd-1 and Tim-3 as Molecular Adjuvants in Mice', Human Vaccines & Immunotherapeutics, 10 (2013), 724-33. Y. Zhang, C. Sun, L. Feng, L. Xiao, and L. Chen, 'Enhancement of Gag-Specific but Reduction of Env- and Pol-Specific Cd8+ T Cell Responses by Simian Immunodeficiency Virus Nonstructural Proteins in Mice', AIDS Res Hum Retroviruses, 28 (2012), 374-83. W. Pan, Z. Dong, W. Meng, W. Zhang, T. Li, C. Li, B. Zhang, and L. Chen, 'Improvement of Influenza Vaccine Strain a/Vietnam/1194/2004 (H5n1) Growth with the Neuraminidase Packaging Sequence from a/Puerto Rico/8/34', Hum Vaccin Immunother, 8 (2012), 252-9. C. Sun, L. Feng, Y. Zhang, L. Xiao, W. Pan, C. Li, L. Zhang, and L. Chen, 'Circumventing Antivector Immunity by Using Adenovirus-Infected Blood Cells for Repeated Application of Adenovirus-Vectored Vaccines: Proof of Concept in Rhesus Macaques', J Virol, 86 (2012), 11031-42. M. Guan, L. Qu, W. Tan, L. Chen, and C. W. Wong, 'Hepatocyte Nuclear Factor-4 Alpha Regulates Liver Triglyceride Metabolism in Part through Secreted Phospholipase a(2) Gxiib', Hepatology, 53 (2011), 458-66. X. Hu, W. Meng, Z. Dong, W. Pan, C. Sun, and L. Chen, 'Comparative Immunogenicity of Recombinant Adenovirus-Vectored Vaccines Expressing Different Forms of Hemagglutinin (Ha) Proteins from the H5 Serotype of Influenza a Viruses in Mice', Virus Res, 155 (2011), 156-62. C. Sun, Y. Zhang, L. Feng, W. Pan, M. Zhang, Z. Hong, X. Ma, X. Chen, and L. Chen, 'Epidemiology of Adenovirus Type 5 Neutralizing Antibodies in Healthy People and Aids Patients in Guangzhou, Southern China', Vaccine, 29 (2011), 3837-41. C. Sun, Y. Zhang, Y. Liu, M. Zhang, and L. Chen, 'Short Communication: Enhancement of Immunogenicity of Replication-Defective Adenovirus-Based Human Immunodeficiency Virus Vaccines in Rhesus Monkeys', AIDS Res Hum Retroviruses, 27 (2011), 681-6. W. Hu, S. Zeng, C. Li, Y. Jie, Z. Li, and L. Chen, 'Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library', J Med Chem, 53 (2010), 3831-4. F. Li, L. Feng, W. Pan, Z. Dong, C. Li, C. Sun, and L. Chen, 'Generation of Replication-Competent Recombinant Influenza a Viruses Carrying a Reporter Gene Harbored in the Neuraminidase Segment', J Virol, 84 (2010), 12075-81. G. Wei, W. Meng, H. Guo, W. Pan, J. Liu, T. Peng, L. Chen, and C. Y. Chen, 'Potent Neutralization of Influenza a Virus by a Single-Domain Antibody Blocking M2 Ion Channel Protein', PLoS One, 6 (2011), e28309. M. Zhong, X. Ma, C. Sun, and L. Chen, 'Micrornas Reduce Tumor Growth and Contribute to Enhance Cytotoxicity Induced by Gefitinib in Non-Small Cell Lung Cancer', Chem Biol Interact, 184 (2010), 431-8.