Johnson, Jill - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

BSc in Honours Biology and Pharmacology Summa Cum Laude, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, 2002 PhD, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada, 2007 PhD Supervisor: Manel Jordana, MD PhD Research Project: Immunological and pharmacological intervention in a novel mouse model of chronic allergic airway disease 2016 – date: Lecturer in Biosciences, School of Life & Health Sciences, Aston University, Birmingham, UK 2011 – 2016: Research Fellow, Inflammation, Repair and Development section, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK 2011: Postdoctoral Fellow, Hamid lab, Meakins-Christie Institute, McGill University, Montréal, QC, Canada 2008 – 2010: Postdoctoral Fellow, Fuxe lab, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

研究领域

Dr Johnson’s research focuses on the role of vascular pericytes in allergic asthma, specifically the progenitor cell capacity of these cells and their contribution to asthma pathogenesis. One of the hallmarks of asthma, airway remodelling, is thought to be facilitated by a chronic inflammatory process driven by allergen exposure. Airway remodelling results in irreversible modifications to structural cells of the airway, ultimately leading to airway narrowing and breathing difficulties. However, unanswered questions remain regarding the cell types that contribute to remodelling, the influence of growth factors and the recruitment of lung-resident progenitor cells. These areas of interest led Jill to investigate pericytes and their roles in asthma. Pericytes are elongated, branched mesenchymal cells that support blood vessels. Pericytes have been described as tissue-specific mesenchymal progenitor cells, and represent an opportunity to extend our knowledge of adult stem cells to understand disease pathogenesis and potential therapeutic interventions.

近期论文

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Johnson JR*, Folestad E, Rowley JE, Noll EM, Walker SA, Lloyd CM, Rankin SM, Pietras K, Eriksson U and Fuxe J. Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.Am J Physiol Lung Cell Mol Physiol. 2015 308(7):L658-71*corresponding author Johnson JR, Nishioka M, Chakir J, Risse P, Almaghlouth I, Bazarbashi AN, Plante S, Martin JG, Eidelman D, Hamid Q. IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells.Respiratory Research 2013 14(1):118 Lavigne F, Petrof BJ, Johnson JR, Lavigne P, Binothman N, Kassissia GO, Al Samri M, Giordano C, Dubé N, Hercz D, Benedetti A, Hamid Q. Effect of topical corticosteroids on allergic airway inflammation and disease severity in obstructive sleep apnoea.Clinical and Experimental Allergy 2013 43(10):1124–1133 Anderberg C, Cunha SI, Zhai Z, Cortez E, Pardali E, Johnson JR, Franco M, Páez-Ribes M, Cordiner R, Fuxe J, Johansson BR, Goumans MJ, Casanovas O, ten Dijke P, Arthur HM, Pietras K. Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination. Journal of Experimental Medicine 2013 210(3):563-79 Johnson JR, Roos A, Berg T, Nord M, Fuxe J. Chronic respiratory aeroallergen exposure in mice induces epithelial-mesenchymal transition in the large airways.PLoS One. 2011 6(1):e16175 Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, Pietras K, Virtanen I, Philipson L, Leopold PL, Crystal RG, de Herreros AG, Moustakas A, Pettersson RF, Fuxe J. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition.Nature Cell Biology 2009 11:943-950 Johnson JR, Pacitto SR, Wong JK, Archer EW, Eirefelt S, Miller-Larsson A, Jordana M. Combined budesonide/formoterol therapy in conjunction with allergen avoidance ameliorates house dust mite-induced airway remodeling and dysfunction.American Journal of Physiology: Lung Cellular and Molecular Physiology 2008 295:L780-788 Rydell-T?rm?nen K*, Johnson JR*, Fattouh R, Jordana M, Erjef?lt JS. Induction of vascular remodeling in the lung by chronic house dust mite exposure. *equal contributions; featured on the journal coverAmerican Journal of Respiratory Cell and Molecular Biology 2008 39(1):61-67 Johnson JR, FK Swirski, BU Gajewska, RE Wiley, R Fattouh, SR Pacitto, JK Wong, MR St?mpfli and M Jordana. Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes.American Journal of Physiology: Lung Cellular and Molecular Physiology 2007 293:L730-739 Johnson JR, Wiley RE, Fattouh R, Swirski FK, Gajewska BU, Coyle AJ, Gutierrez-Ramos J-C, Ellis R, Inman MD and Jordana M. Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling.American Journal of Respiratory and Critical Care Medicine 2004 169:378-385 *featured on the journal cover