Hewitt, Chris - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

D.Sc. in Biochemical Engineering, Loughborough University, 2013. Ph.D. in Biochemical Engineering, University of Birmingham, 1993. B.Sc. with First Class Honours in Biology, University of London, Royal Holloway College, 1990. P.G.Cert. Higher Education, Teaching and Learning, University of Birmingham, 2002. 2006 to 2014: Associate Dean for Research (School of Aero, Auto, Chemical and Materials Engineering - 2011) and Professor of Biological Engineering (2006), Chemical Engineering, Loughborough University, 1999 to 2006: Lecturer then Senior Lecturer (2004) in Biochemical Engineering, Chemical Engineering, University of Birmingham.

研究领域

I have been working in the field of Biological Engineering for over 20 years seeking to study the interaction of the organism with the process environment using such non-invasive techniques as flow cytometry, image analysis and NIR spectroscopy. These techniques have been used to improve our understanding of how cells behave within such diverse areas as Microbial Fermentation, Bio-remediation, Bio-transformation, Brewing, Regenerative Medicine Bioprocessing and Cell Culture. This work has been carried out mostly with industrial collaborators, the motivation being process improvement and optimisation for informed scale-up/out. I have acted as a bioprocessing consultant for companies such as Celgene (US), Coors, Novozymes (Sweden), Emergent Biosolutions, Merck, Unilever, Oxoid Ltd, Field Supplies Ltd, Degussa-Huels, Cobra Therapeutics and GSK advising on appropriate analytical techniques and all types of bioprocess development.

近期论文

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Heathman, TRJ, Rafiq, QA, Chan, AKC, Coopman, K, Nienow, AW, Kara, B & Hewitt, CJ 2016, 'Characterization of human mesenchymal stem cells from multiple donors and the implications for large scale bioprocess development' Biochemical Engineering Journal, vol. 108, pp. 14-23,10.1016/j.bej.2015.06.018 Heathman, TRJ, Stolzing, A, Fabian, C, Rafiq, QA, Coopman, K, Nienow, AW, Kara, B & Hewitt, CJ 2016, 'Scalability and process transfer of mesenchymal stromal cell production from monolayer to microcarrier culture using human platelet lysate' Cytotherapy, vol. 18, no. 4, pp. 523-535,10.1016/j.jcyt.2016.01.007 Rafiq, QA, Coopman, K, Nienow, AW & Hewitt, CJ 2016, 'Systematic microcarrier screening and agitated culture conditions improves human mesenchymal stem cell yield in bioreactors' Biotechnology Journal, vol. 11, no. 4, pp. 473–486,10.1002/biot.201400862 Heathman, TRJ, Stolzing, A, Fabian, C, Rafiq, QA, Coopman, K, Nienow, AW, Kara, B & Hewitt, CJ 2015, 'Serum-free process development: improving the yield and consistency of human mesenchymal stromal cell production' Cytotherapy, vol. 17, no. 11, pp. 1524-1535,10.1016/j.jcyt.2015.08.002 Nienow, AW, Hewitt, CJ, Heathman, TRJ, Glyn, VAM, Fonte, GN, Hanga, MP, Coopman, K & Rafiq, QA 2015, 'Agitation conditions for the culture and detachment of hMSCs from microcarriers in multiple bioreactor platforms' Biochemical Engineering Journal, vol. 108, pp. 24-29,10.1016/j.bej.2015.08.003 Rafiq, QA & Hewitt, CJ 2015, 'Cell therapies: why scale matters' Pharmaceutical Bioprocessing, vol. 3, no. 2, pp. 97-99,10.4155/pbp.14.63 Heathman, TRJ, Glyn, VAM, Picken, A, Rafiq, QA, Coopman, K, Nienow, AW, Kara, B & Hewitt, CJ 2015, 'Expansion, harvest and cryopreservation of human mesenchymal stem cells in a serum-free microcarrier process' Biotechnology and Bioengineering, vol. 112, no. 8, pp. 1696-1707,10.1002/bit.25582 Heathman, TRJ, Nienow, AW, McCall, MJ, Coopman, K, Kara, B & Hewitt, CJ 2015, 'The translation of cell-based therapies: clinical landscape and manufacturing challenges' Regenerative medicine, vol. 10, no. 1, pp. 49-64,10.2217/rme.14.73 Nienow, AW, Rafiq, QA, Coopman, K & Hewitt, CJ 2014, 'A potentially scalable method for the harvesting of hMSCs from microcarriers' Biochemical Engineering Journal, vol. 85, pp. 79-88,10.1016/j.bej.2014.02.005 Rafiq, QA, Brosnan, KM, Coopman, K, Nienow, AW & Hewitt, CJ 2013, 'Culture of human mesenchymal stem cells on microcarriers in a 5 l stirred-tank bioreactor' Biotechnology Letters, vol. 35, no. 8, pp. 1233-1245,10.1007/s10529-013-1211-9 Rafiq, QA, Coopman, K, Nienow, AW & Hewitt, CJ 2013, 'A quantitative approach for understanding small-scale human mesenchymal stem cell culture - implications for large-scale bioprocess development' Biotechnology Journal, vol. 8, no. 4, pp. 459-471,10.1002/biot.201200197 Rafiq, QA, Coopman, K & Hewitt, CJ 2013, 'Scale-up of human mesenchymal stem cell culture: current technologies and future challenges' Current Opinion in Chemical Engineering, vol. 2, no. 1, pp. 8-16,10.1016/j.coche.2013.01.005 Routledge, SJ, Hewitt, CJ, Bora, N & Bill, RM 2011, 'Antifoam addition to shake flask cultures of recombinantPichia pastorisincreases yield' Microbial Cell Factories, vol. 10, no. 17, 17,10.1186/1475-2859-10-17 Al-Malaika, S, Hewitt, C & Sheena, HH 2010, 'Photodegradable polymers' . in NS Allen (ed.),Photochemistry and photophysics of polymer materials.Wiley, Hoboken, NJ (US), pp. 603-626,10.1002/9780470594179.ch16