Balklava, Zita - Aston University - School of Life & Health Sciences, Biology/Biosciences

个人简介

1996 BSc in Biology, University of Latvia 1998 MSc in Biology, University of Latvia 2002 PhD in Biochemistry, Nottingham Trent University 2009 - Royal Society Dorothy Hodgkin Fellow, Aston University 2008-2009 Royal Society Dorothy Hodgkin Fellow, University of Manchester (UK) 2008 - Postdoctoral Research Fellow, University of Manchester (UK) 2003-2007 Postdoctoral Research Fellow, Rutgers- the State University of New Jersey (USA) 2002-2003 Postdoctoral Research Fellow, University of Medicine and Dentistry of New Jersey (USA)

研究领域

Membrane trafficking pathways target various molecules to their specific destinations within the cell as well as in and out of the cell, and thus are essential for fundamental aspects of eukaryotic life including nutrient uptake, growth factor regulation, synaptic signal transduction, infection, etc. Importance of these pathways is illustrated by the growing number of diseases and cancers associated with defects in these pathways. A number of reports have shown that various signalling molecules physically associate with endomembranes, thus being ideally placed to control membrane traffic or traffic-mediated signalling. The research in our laboratory aims to understand how membrane trafficking and cell signalling are coupled within the cell.Powerful genetics in combination with the relatively simple cellular complexity of the soil nematode Caenorhabditis elegans has been proven to be beneficial in studying membrane transport and cell signalling pathways in vivo. C.elegans Fibroblast Growth Factor Receptor (FGFR) has been found in a genome-wide RNAi screen as a candidate regulator of constitutive secretion. The main goal of the project is to dissect the role of FGFR in controlling membrane transport.

近期论文

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Balklava, Z, Rathnakumar, ND, Vashist, S, Schweinsberg, PJ & Grant, BD 2016, 'Linking gene expression in the intestine to production of gametes through the phosphate transporter PITR-1 inCaenorhabditis elegans' Genetics, vol. Early online,10.1534/genetics.116.188532 Guscott, B, Balklava, Z, Safrany, ST & Wassmer, T 2016, 'A cell-permeable tool for analysing APP intracellular domain function and manipulation of PIKfyve activity' Bioscience Reports, vol. 36, no. 2, e00319,10.1042/BSR20160040 Currinn, H, Guscott, B, Balklava, Z, Rothnie, A & Wassmer, T 2016, 'APP controls the formation of PI(3,5)P2vesicles through its binding of the PIKfyve complex' Cellular and Molecular Life Sciences, vol. 73, no. 2, pp. 393-408,10.1007/s00018-015-1993-0 Balklava, Z, Niehage, C, Currinn, H, Mellor, L, Guscott, B, Poulin, G, Hoflack, B & Wassmer, T 2015, 'The amyloid precursor protein controls PIKfyve function' PLoS ONE, vol. 10, no. 6, e0130485,10.1371/journal.pone.0130485 Balklava, Z & Sztul, E 2013, 'Studying membrane trafficking in the worm C. elegans by RNA interference' Methods in Cell Biology, vol. 118, pp. 51-68,10.1016/B978-0-12-417164-0.00004-5 Grabski, R, Balklava, Z, Wyrozumska, P, Szul, T, Brandon, E, Alvarez, C, Holloway, ZG & Sztul, E 2012, 'Identifying a novel functional domain within the p115 tethering factor required for Golgi ribbon assembly and membrane trafficking' Journal of Cell Science, vol. 125, no. 8, pp. 1896-1909,10.1242/jcs.090571 Morohashi, Y, Balklava, Z, Ball, M, Hughes, H & Lowe, M 2010, 'Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis' Biochemical Journal, vol. 427, no. 3, pp. 401–412,10.1042/BJ20091681