MacMillan, John - UT Southwestern Medical Center

个人简介

Biography Post-doc: Scripps Institution of Oceanography Ph.D.: University of California, Davis (Chemistry) B.Sc.: University of Iowa (Chemistry) Education Undergraduate University of Iowa Graduate School University of California-Davis (2004) Honors & Awards Chilton/Bell Scholar in Biochemistry (0)

研究领域

Research Interest antibiotics cancer biology drug discovery marine microbiology natural products organic chemistry polyketides target identification

近期论文

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Inducamides A–C, Chlorinated Alkaloids from an RNA Polymerase Mutant Strain of Streptomyces sp. Peng Fu, Matthew Jamison, Scott La, and John B. MacMillan Org. Lett., 2014, 16, pp 5656-5659 Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection Mehabaw G. Derebe, Clare M. Zlatkov, Sureka Gattu, Kelly A. Ruhn, Shipra Vaishnava, Gretchen E. Diehl, John B. MacMillan, Noelle S. Williams, and Lora V. Hopper eLife, 2014, 3, e03206 Carpatamides A–C, Cytotoxic Arylamine Derivatives from a Marine-Derived Streptomyces sp. Peng Fu, Melissa Johnson, Hong Chen, Bruce A. Posner, and John B. MacMillan J. Nat. Prod., 2014, 77, pp 1245-1248 Discoipyrroles A–D: Isolation, Structure Determination, and Synthesis of Potent Migration Inhibitors from Bacillus hunanensis Youcai Hu, Malia B. Potts, Dominic Colosimo, Mireya L. Herrera-Herrera, Aaron G. Legako, Muhammed Yousufuddin, Michael A. White, and John B. MacMillan J. Am. Chem. Soc., 2013, 135, pp 13387-13392 Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor Jamie L. Rogers, Liela Bayeh, Thomas H. Scheuermann, Jamie Longgood, Jason Key, Jacinth Naidoo, Lisa Melito, Cameron Shokri, Doug E. Frantz, Richard K. Bruick, Kevin H. Gardner, John B. MacMillan, and Uttam K. Tambar J. Med. Chem., 2013, 56, pp 1739–1747 Hunanamycin A, An Antibiotic from a Marine Derived Bacillus hunanensis Youcai Hu, Kezhan Wang, and John B. MacMillan Org. Lett., 2013, 15, pp 390–393. Using Functional Signature Ontology (FUSION) to Identify Mechanisms of Action for Natural Products Malia B. Potts, Hyun Seok Kim, Kurt W. Fisher, Youcai Hu, Yazmin Carrasco, Gamze Betul Bulut, Yi-Hung Ou, Mireya L. Herrera-Herrera, Federico Cubillos, Saurabh Mendiratta, Guanghua Xiao, Matan Hofree, Trey Ideker, Yang Xie, Lily Jun-shen Huang, Robert E. Lewis*, John B. MacMillan*, and Michael A. White* Sci. Signal., 2013, 6, ra90 Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P Ende Pan, Nathaniel W. Oswald, Aaron G. Legako, Janie M. Life, Bruce A. Posner and John B. MacMillan Chem. Sci., 2013, 4, pp 482–488 Nuclear Export Inhibition through Covalent Conjugation and Hydrolysis of Leptomycin B by CRM1 Qingxiang Sun, Yazmin P. Carrasco, Youcai Hu, Xiaofeng Guo, Hamid Mirzaei, John B. MacMillan, and Yuh Min Chook PNAS, 2013, 110, pp 1303–1308 Anthraquinones from a Marine-derived Streptomyces spinoverrucosus Youcai Hu, Elisabeth A. Martinez, John B. MacMillan J. Nat. Prod., 2012, 75, pp 1759–1764 A Labeled Substrate Approach to Discovery of Biocatalytic Reactions: A Proof of Concept Transformation with N-Methylindole Jamie L. Rogers and John B. MacMillan J. Am. Chem. Soc., 2012, 134, pp 12378–12380. Ammosamide D, an Oxidatively Ring Opened Ammosamide Analog from a Marine-derived Streptomyces variabilis Ende Pan, Matthew Jamison, Muhammed Yousufuddin, and John B. MacMillan Org. Lett., 2012, 14, pp 2390–2393. Erythrolic Acids A-E, Meroterpenoids from a Marine-derived Erythrobacter sp. Youcai Hu, Aaron G. Legako, Ana Paula D.M. Espindola, and John B. MacMillan J. Org. Chem., 2012. 77, pp 3301–3307 A New Peptide Isolated from a Marine derived Streptomyces bacillaris Youcai Hu and John B. MacMillan Nat. Prod. Comm., 2012, 7, pp 211–214 Erythrazoles A-B, Cytotoxic Benzothiazoles from a Marine-derived Erythrobacter sp. Youcai Hu and John B. MacMillan Org. Lett., 2011, 13, pp 6580–6583 Chromomycin SA analogs from a marine-derived Streptomyces sp. Youcai Hu, Ana Paula D. M Espindola, Nathan A. Stewart, Shuguang Wei, Bruce A. Posner, and John B. MacMillan Bioorg. Med. Chem. 2011, 19, pp 5183–5189. Towards patient-based cancer therapeutics The Cancer Target Discovery and Development Network, Stuart L Schreiber, Alykhan F Shamji, Paul A Clemons, Cindy Hon, Angela N Koehler, Benito Munoz, Michelle Palmer, Andrew M Stern, Bridget K Wagner, Scott Powers, Scott W Lowe, Xuecui Guo, Alex Krasnitz, Eric T Sawey, Raffaella Sordella, Lincoln Stein, Lloyd C Trotman, Andrea Califano, Riccardo Dalla-Favera, Adolfo Ferrando, Antonio Iavarone, Laura Pasqualucci, José Silva, Brent R Stockwell, William C Hahn, Lynda Chin, Ronald A DePinho, Jesse S Boehm, Shuba Gopal, Alan Huang, David E Root, Barbara A Weir, Daniela S Gerhard, Jean Claude Zenklusen, Michael G Roth, Michael A White, John D Minna, John B MacMillan, and Bruce A Posner Nat Biotechnol., 2010, 9, pp 904–906 Deconvolution of complex NMR spectra in small molecules by multifrequency homonuclear decoupling (MDEC) Ana Paula D. M. Espindola, Ronald Crouch, John R. DeBergh, Joseph M. Ready, and John B. MacMillan J. Am. Chem. Soc. 2009, 131, pp 15994–15995. RNA polymerase III detects cytosolic DNA and induces type I interferon’s through the RIG-I pathway Yu-Hsin Chiu, John B. MacMillan, and Zhijian J. Chen Cell, 2009,138, pp 576–591. Prior to UTSW Maloney, K.; MacMillan, J.B.; Kauffman, C.; Jensen, P.R.; DiPasquale, A.; Fenical, W. Lodopyridone, a Structurally-Unprecedented Alkaloid from a Marine Actinomycete Org. Lett., 2009 11, 5422-5424. Hughes, C.C.; MacMillan, J.B.; Gaudencio, S.P.; Jensen, P.R.; Fenical, W. The Ammosamides, Structures of Potent Cytotoxins from a Marine-Derived Streptomyces sp. Angew. Chemie Int. Ed., 2009, 48, 725-727.