Ahmad, Shakil - Aston University - Aston Medical School

个人简介

BSc in Biochemistry, University of Kent, 1999 PhD in Vascular Biology, University of Birmingham, 2005 2013 – Current: Senior Research Fellow, Aston Medical School, Aston University. 2010 – 2013: Faculty Principal Investigator / Lecturer in BHF Centre for Cardiovascular Sciences, University of Edinburgh. 2005 – 2010: RCUK Robert’s Research Fellow in College of Medical and Dental Sciences, University of Birmingham 2004 – 2006: Postdoctoral Researcher in College of Medical and Dental Sciences, University of Birmingham.

研究领域

Preeclampsia, a maternal hypertensive condition, is a new risk factor for cardiovascular disease. Key proteins of interest in the disorder are vascular endothelial growth factor and its endogenous antagonist, soluble Flt-1 (sFlt-1). My research activity has focused on understanding their signaling transduction in endothelial cells and placenta. Previously I identified sFlt-1, which is elevated in pregnancies complicated with preeclampsia, as the principal factor responsible for the reduced placental angiogenesis associated with preeclampsia. Ongoing work is aimed at the development of novel in vivo models for preeclampsia and the use of transgenic animals to define how sFlt-1 causes preeclampsia-like condition. Specifically, I am interested in the interaction of these factors with pro-atherogenic chemokines and their role in the disease progression

近期论文

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Ahmad S, Hewett PW, Fujisawa T, Sissaoui S, Cai M, Gueron G, Cudmore M, Ahmed SF, Wong MK, Wegiel B, Otterbein LE, Vítek L, Ramma W, Wang K, Ahmed A. Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation. Thromb Haemost. 2015 Feb;113(2):329-37. (PMID: 25354586) Liu X, Turban S, Carter RN, Ahmad S, Ramage L, Webster SP, Walker BR, Seckl JR, Morton NM. β- Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction. Front Endocrinol (Lausanne). 2014 Oct 14;5:165. (PMID: 25352830) Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, Baily J, Miller MR, Cudmore M, Hadoke PW, Wang R, Gratacós E, Buhimschi IA, Buhimschi CS, Ahmed A. Response to Letter Regarding Article, "Dysregulation of Hydrogen Sulfide (H2S) Producing Enzyme Cystathionine γ-lyase (CSE) Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia". Circulation. 2014 Jun 3;129(22):e517-8. (PMID: 24891630) Vítek L, Gbelcová H, Muchová L, Ván?ová K, Zelenka J, Koníc?ková R, Suk J, Zadinova M, Knejzlík Z, Ahmad S, Fujisawa T, Ahmed A, Ruml T. Antiproliferative effects of carbon monoxide on pancreatic cancer. Dig Liver Dis. 2014 Apr;46(4):369-75. (PMID: 24433995) Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, Baily J, Miller MR, Cudmore M, Hadoke PW, Wang R, Gratacós E, Buhimschi IA, Buhimschi CS, Ahmed A. Dysregulation of Hydrogen Sulfide (H2S) Producing Enzyme Cystathionine γ-lyase (CSE) Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia. Circulation. 2013 May 23. (PMID: 23704251) Cudmore MJ, Hewett PW, Ahmad S, Wang KQ, Cai M, Al-Ani B, Fujisawa T, Ma B, Sissaoui S, Ramma W, Miller MR, Newby DE, Gu Y, Barleon B, Weich H, Ahmed A. The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis. Nat Commun. 2012 Jul 24;3:972. (PMID: 22828632) Cudmore MJ, Ramma W, Cai M, Fujisawa T, Ahmad S, Al-Ani B, Ahmed A. Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta. Am J Obstet Gynecol. 2012 Mar;206(3):253.e10-5. (PMID: 22197494) Rosenberg VA, Buhimschi IA, Lockwood CJ, Paidas MJ, Dulay AT, Ramma W, Abdel-Razeq SS, Zhao G, Ahmad S, Ahmed A, Buhimschi CS. Heparin elevates circulating soluble fms-like tyrosine kinase-1 immunoreactivity in pregnant women receiving anticoagulation therapy. Circulation. 2011 Dec 6;124(23):2543-53. (PMID: 22082677) Ahmad S, Hewett PW, Al-Ani B, Sissaoui S, Fujisawa T, Cudmore MJ, Ahmed A. Autocrine activity of soluble Flt-1 controls endothelial cell function and angiogenesis. Vasc Cell. 2011 Jul 13;3(1):15. (PMID: 2175227) Cudmore MJ, Ahmad S, Sissaoui S, Ramma W, Ma B, Fujisawa T, Al-Ani B, Wang K, Cai M, Crispi F, Hewett PW, Gratacós E, Egginton S, Ahmed A. Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase- 1. Eur Heart J. 2011 Mar 16. (PMID: 21411816) Ahmad S, Cudmore MJ, Wang K, Hewett P, Potluri R, Fujisawa T, Ahmed A. Angiopoietin-1 induces migration of monocytes in a tie-2 and integrin-independent manner. Hypertension. 2010 Sep;56(3):477- 83. (PMID: 20696992)