Cai, Meng - Aston University - Aston Medical School

个人简介

Ph.D 2001-2007: The National Key Laboratory of Crop Genetics and Improvement, Huazhong Agricultural University, Wuhan, China. Major: Molecular Biology and Biochemistry Bachelor of Science 1998-2001: College of Life science and technology, Huazhong Agricultural University, Wuhan, China Major: Biology Technology

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Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta. Cudmore MJ, Ramma W, Cai M, Fujisawa T, Ahmad S, Al-Ani B, Ahmed A. (Am J Obstet Gynecol. 2012, 206:253.e10-5) Heterodimerization of VEGFR-1 (Flt-1) with VEGFR-2 (KDR) regulates endothelial vascular homeostasis and angiogenesis. Melissa Cudmore, Peter Hewett, Shakil Ahmad, Ke-Qing Wang, Meng Cai, Bahjat Al-Ani, Takeshi Fujisawa, Bin Ma, Samir Sissaoui, Wenda Ramma, Mark R. Miller, David E. Newby, Yuchun Gu, Bernhard Barleon, Herbert Weich, and Asif Ahmed. (Nat Commun. 2012, Jul 24; 3:972. doi: 10.1038/ncomms1977) Dysregulation of the hydrogen sulfide (H2S)-producing enzyme cystathionine γ-lyase (CSE) contributes to maternal hypertension and placental abnormalities in preeclampsia. Keqing Wang, Meng Cai, Jillian Rennie, Takeshi Fujisawa, Melissa J. Cudmore, James Baily, Patrick W. F. Hadoke, Irina A. Buhimschi, Catlin S. Buhimschi, Shakil Ahmad and Asif Ahmed. (Circulation. 2013;127:2514-2522) Loss of Akt activity increases circulating soluble endoglin release in preeclampsia: identification of inter-dependency between Akt-1 and heme oxygenase-1. Cudmore MJ, Ahmad S, Sissaoui S, Ramma W, Ma B, Fujisawa T, Al-Ani B, Wang K, Cai M, Crispi F, Hewett PW, Gratacós E, Egginton S, Ahmed A. (Eur Heart J. 2012, 33:1150-1158) Endothelial Nitric Oxide Synthase and Heme Oxygenase regulate Angiogenesis via p21WAF1 in a diametrically opposed manner. M. Cai, B. Al-Ani, S. Ahmad, T. Fujisawa, M. J. Cudmore, A. Ahmed (2012, in preparation) MiR-152 controls angiogensis via direct targeting Integrin alpha 5 in diabetes mellitus. Meng Cai, Melissa Cudmore, Keqing Wang, Shakil Ahmad, Takeshi Fujisawa, Jillian Rennie, Asif Ahmed (2012, in preparation) MiR-195 regulates angiogenesis and cell proliferation via endothelial nitric oxide synthase in diabetes mellitus. Meng Cai, Melissa Cudmore, Keqing Wang, Shakil Ahmad, Takeshi Fujisawa, Jillian Rennie, Asif Ahmed (2012, in preparation) WRKY13, a gene mediating the interaction of salicylate- and jasmonate-dependent pathways in rice disease resistance, is regulated by multiple cis- and trans-acting elements. Meng Cai, Caiguo Xu, Xianghua Li, and Shiping Wang (Plant, Cell & Environment, 31: 86-96, 2008) A rice promoter containing both novel positive and negative cis-elements for regulating green-tissue-specific gene expression in transgenic plants. Meng Cai, Jun Wei, Caiguo Xu, Xianghua Li, and Shiping Wang (Plant Biotechnology Journal, 5:664-674, 2007) Identification of proteins bound to the tissue-specific positive and negative cis-acting elements of a rice green tissue-specific promoter. Meng Cai, Ting Yuan, Liu Duan, Xianghua Li, Shiping Wang (Plant Biology, 10: 717-777, 2008) Analysis of rice genes induced by striped stemborer (Chilo suppressalis) attack identified a promoter fragment highly specifically responsive to insect feeding. Hua H, Lu Q, Cai M, Xu C, Zhou D, Li X, Zhang Q. (Plant Molecular Biology, 2007, 69: 519-530) The expression pattern of a rice disease resistance gene Xa3/Xa26 is differentially regulated by the genetic backgrounds and developmental stages that influence its function. Cao Y, Ding X, Cai M, Zhao J, Lin Y, Li X, Xu C, Wang S. (Genetics, 2007, 177: 523-533) WRKY13 Mediates Rice Disease Resistance by Regulating Defense-related Genes in Salicylate- and Jasmonate-dependent Signaling. Deyun Qiu, Jun Xiao, Xinhua Ding, Min Xiong, Meng Cai, Yinglong Cao, Xianghua Li, Caiguo Xu, and Shiping Wang (Molecular Plant-Microbe Interactions, 20: 492-499, 2007) International Conference Presentation: Endothelial Nitric Oxide Synthase and Heme Oxygenase regulate Angiogenesis via p21WAF1 in a diametrically opposed manner (oral presentation) Meng Cai, Bahjat Al-Ani, Shakil Ahmad (7th International Congress on the Heme Oxygenases and related enzymes, Jun 2012, Edinburgh, UK) Endothelial Nitric Oxide Synthase and Heme Oxygenase regulate Angiogenesis via p21WAF1 in a diametrically opposed manner (oral presentation) M. Cai, B. Al-Ani, S. Ahmad, T. Fujisawa, M. J. Cudmore, A. Ahmed (Scottish Cardiovascular Forum 2011, Aberdeen, UK) Characterization a pathogen- and multi-hormone induced promoter and identification the cis and trans elements for response to pathogen iduction Meng Cai, Min Xiong, Shiping Wang (ISPMB, the international congress in plant molecular biology, 2006, Adelaide, Australia) Characterization a pathogen- and multi-hormone induced promoter and identification the regulatory elements for response to pathogen iduction Meng Cai, Min Xiong, Shiping Wang (the Plant Genomics in China, 2005, Kunming) The green-tissue expression promoter containing the negative elements for controlling the non-expression of certain tissues Meng Cai, Jun Wei, Jun Wei, Shiping Wang (the Plant Genomics in China, 2004, Wuhan) Identification and isolation of pathogen-induced and tissue-specific promoters Meng Cai, Min Xiong, Jun Wei, Shiping Wang (the Plant Genomics in China, 2003, Xi’an)