Murdoch, Colin - Aston University - Aston Medical School

个人简介

2004 -2009 - British Heart Foundation Ph.D student. King’s College London, UK. Research Project: Influence of endothelial redox state on cardiac remodelling in response to chronic pressure overload. 1996 – 2000 - Undergraduate Pharmacology with Honors and Industrial Placement University of Edinburgh, UK. 2014 - Marie Curie International Fellow 2011- 2013 - Post-Doctoral Research Scholar Cohen Laboratory, Vascular Biology Unit. Boston School of Medicine. Boston University, MA. 2009 -2011 - Post-Doctoral Fellow. Cardiovascular Division, BHF Centre of Excellence, King’s College London, UK. 2004 -2009 - British Heart Foundation Ph.D student. King’s College London, UK. Research Project: Influence of endothelial redox state on cardiac remodeling in response to chronic pressure overload. 2000 -2004 - Scientist, Asterand PLC. Royston UK.

研究领域

I am interested in how redox signaling affects cardiovascular pathophysiology. In particular my research has concentrated on signaling in the endothelial and inflammatory cell and the implication on cardiovascular function in vivo. I am currently investigating a number of targets in pre-eclampsia using a wide range of clinical samples, murine models and in vitro studies. One aspect is to investigate during pre-eclampsia whether signaling is affected by the S- glutathionylation, a post-translation modification which occurs during oxidative stress. My previous research in Boston was to identify how angiogenesis can be regulated by S- glutathionylation. In Kings College London I investigated the cell specific role of isoforms of the NADPH oxidase enzymes, Nox2 and Nox4 in the endothelium on left ventricular hypertrophy and hypertension. I successfully modeled a human disease in a mouse, measured cardiovascular parameters and subsequently conducted biochemical and molecular assays in order to identify novel molecular mechanisms. I have spent time working in industry where I helped find novel targets for disease and tested possible drug candidates.

近期论文

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Murdoch CE, Chaubey S, Zeng L, Yu B, Ivetic A, Walker SJ, Vanhoutte D, Heymans S, Grieve DJ, Cave AC, Brewer AC, Zhang M, Shah AM. Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through pro-inflammatory effects and endothelial-mesenchymal transition. J Am Coll Cardiol. 2014 Mar 14. pii: S0735-1097(14). (Accompanied by editorial). Murdoch CE, Shuler M, Haeussler DJ, Kikuchi R, Bearelly P, Han J, Watanabe Y, Fuster JJ, Walsh K, Ho YS, Bachschmid MM, Cohen RA, Matsui R. Glutaredoxin-1 Up-regulation Induces Soluble Vascular Endothelial Growth Factor Receptor 1, Attenuating Post-ischemia Limb Revascularization. J Biol Chem. 2014 Mar 21;289(12):8633-44 Drozdov, A Didangelos, X Yin, A Zampetaki, M Abonnenc, CE Murdoch, M Zhang, C Ouzounis, M Mayr, S Tsoka, Ajay M Shah. Gene network and proteomic analyses of cardiac responses to pathological and physiological stress . Circ Cardiovasc Genet. 2013. Nov 8. Murdoch CE, Alom-Ruiz SP, Wang M, Walker S, Yu B, Brewer AC, Shah AM. Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol. 2011 Jun;106(4):527-38. (Accompanied by editorial). Murdoch CE, Ray R, Wang M, Zhang M, Alom-Ruiz S, Ouattara A, Cave AC, Walker SJ,Grieve DJ, Charles R, Eaton P, Brewer AC, Shah AM. Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo. Arterioscler Thromb Vasc Biol. 2011. Jun;31(6):1368-76. (Accompanied by editorial). Webb IG, Nishino Y, Clark JE, Murdoch C, Walker SJ, Makowski MR, Botnar RM, Redwood SR, Shah AM, Marber MS. Constitutive glycogen synthase kinase-3(α)/(β) activity protects against chronic(β)-adrenergic remodelling of the heart. Cardiovasc Res. 2010;Mar ; 87(3):494-503. Humphries J, Gossage JA, Modarai B, Burnand KG, Sisson TH, Murdoch C, Smith A. Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis. J Vasc Surg. 2009; Nov;50(5):1127-34. Kis A, Murdoch C, Zhang M, Siva A, Rodriguez-Cuenca S, Carobbio S, Lukasik A, Blount M,O'Rahilly S, Gray SL, Shah AM, Vidal-Puig A. Defective peroxisomal proliferators activatedreceptor gamma activity due to dominant-negative mutation synergizes with hypertension toaccelerate cardiac fibrosis in mice. Eur J Heart Fail. 2009; Jun;11(6):533-41. Davis RJ, Murdoch CE, Ali M, Purbrick S, Ravid R, Baxter GS, Tilford N, Sheldrick RL, Clark KL, Coleman RA. EP4 prostanoid receptor-mediated vasodilatation of human middle cerebral arteries. Br J Pharmacol. 2004;141:580-585.