Kürti, László - Rice University - Department of Chemistry

个人简介

Lászlo Kürti was born and raised in Hungary. He received his Diploma from Lajos Kossuth University (now University of Debrecen) where he conducted research in the laboratory of Professor Sándor Antus focusing on the total synthesis of benzofuranoid neolignans. Subsequently he received his Master of Science degree at the University of Missouri-Columbia, working with Professor Michael Harmata on inter- and intramolecular [4+3]-cycloadditions of halogen-substituted oxoallylic cations. He received his PhD degree (2006) in synthetic organic chemistry under the supervision of Professor Amos B. Smith III at the University of Pennsylvania, where he developed a new method for the construction of highly substituted and strained indoles that was applied in the synthetic studies toward the construction of the complex indole diterpenoid natural products, nodulisporic acids A and B. During graduate school, Dr. Kürti authored the now popular textbook/reference book Strategic Applications of Named Reactions in Organic Synthesis with Dr. Barbara Czako, which is now used in dozens of academic institutions and research laboratories worldwide. Between 2007-2010, Dr. Kürti was a Damon Runyon Cancer Fellow in the group of Professor E.J. Corey at Harvard University, where he was working on the development of potent antiangiogenic agents inspired by the structure of Cortistatin A. In 2007 he co-authored the book Molecules and Medicine with Professor E.J. Corey and Dr. Barbara Czako. In February 2008, the Professional and Scholarly Division of the American Association of Publishers designated Molecules and Medicine “Best of Physical Sciences and Mathematics.” Professor Corey and Dr. Kürti just completed a book entitled Enantioselective Chemical Synthesis, available in October. This book provides in a single volume an up-to-date and panoramic view of all aspects of enantioselective chemistry. The reader who masters the information and ideas contained on its pages will be superbly positioned as a teacher or researcher in this exciting field of chemistry. EMPLOYMENT AND EDUCATION Associate Professor–Tenure Track Position at Rice University 2015 June Assistant Professor–Tenure TrackPosition at UT Southwestern Medical Center, Dallas, TX 2010-2015 Postdoctoral Studies–Harvard University, Cambridge, MA 2006-2010 Ph.D. in Organic Chemistry–University of Pennsylvania, Philadelphia, PA 2001-2006 Masters Degree in Organic Chemistry–University of Missouri, Columbia, MO 2001 June Diploma in Chemistry–Lajos Kossuth University (now Univ. of Debrecen), Debrecen, Hungary 1998 June Diploma in English Hungarian Technical Translation -Lajos Kossuth University (now Univ. of Debrecen), Debrecen, Hungary 1997 June Honors & Awards Best of Physical Sciences and Mathematics in Professional and Scholarly Publishing For the book "Molecules and Medicine" written by E.J. Corey, Barbara Czako and Lászlo Kurti (2008) Damon Runyon Cancer Fellowship Awarded by the Damon Runyon Cancer Research Foundation (2007) Outstanding Academic Title Designation By Choice Magazine for the book "Strategic Applications of Named Reactions in Organic Synthesis" written by Laszlo Kurti and Barbara Czako (2007) Award for Excellence in Professional and Scholarly Publishing For "Strategic Applications of Named Reactions in Organic Synthesis" written by Laszlo Kurti and Barbara Czako. This award is given by the American Association of Publishers Scholarly Publishing Div. to acknowledge excellence in book publishing (2006) Dean´s Teaching Award University of Pennsylvania (2006)

研究领域

New enantioselective methods for C-C and C-X bond formation New methods for the synthesis of heterocyclic compounds Total synthesis of bioactive natural and unnatural products

近期论文

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Hongyin Gao, Zhe Zhou, Doo-Hyun Kwon, James Coombs, Steven Jones, Nicole Erin Behnke, Daniel H. Ess, László Kürti, "Rapid heteroatom transfer to arylmetals utilizing multifunctional reagent scaffolds." Nature Chemistry 2016, (DOI: 10.1038/NCHEM.2672). C&EN News of the Week Mahesh P. Paudyal, Adeniyi Michael Adebesin, Scott R. Burt, Daniel H. Ess, Zhiwei Ma, László Kürti, John R. Falck. "Dirhodium-catalyzed C-H arene amination using hydroxylamines." SCIENCE 2016, Vol 353, no 6304, p 1144-1147 (DOI: 10.1126/science.aaf8713). Highlighted by Synfacts Jin-Zheng Wang, Jin Zhou, Chang Xu, Hongbin Sun*, László Kürti*, and Qing-Long Xu*. “Symmetry in Cascade Chirality-Transfer Processes: A Catalytic Atroposelective Direct Arylation Approach to BINOL Derivatives.” J. Am. Chem. Soc. 2016, 138, 5202-5205 (http://pubs.acs.org/doi/abs/10.1021/jacs.6b01458). Gao, Hongyin; Xu, Qing-Long; Keene, Craig; Yousufuddin, Muhammed; Ess, Daniel H. and Kürti, László*. "Practical Organocatalytic Synthesis of Functionalized Non-C2-Symmetrical Atropisomeric Biaryls.” Angew. Chem. Int. Ed. 2016, 55, 566-571 ( Hot Paper; http://onlinelibrary.wiley.com/doi/10.1002/anie.201508419/pdf). Kürti, László. “Streamlining Amine Synthesis” – A Perspective. SCIENCE 2015, Vol 348, no 6237, p864-865 (DOI:10.1126/science.aab2812). Gao, Hongyin; Xu, Qing-Long; Keene, Craig and Kürti, László*. "Scalable, Transition-Metal-Free Direct Oxime O-Arylation: Rapid Access to O-arylhydroxylamines and Substituted Benzo[b]furans.” Chemistry – A European Journal 2014, 20, 8883-8887 (http://onlinelibrary.wiley.com/doi/10.1002/chem.201403519/pdf). Wood, Ross M.; Patel, Darshan C.; Lim, Yeeun, Breitbach, Zachary S.; Gao, Hongyin; Keene, Craig; Li, Gongqiang; Kürti, László and Armstrong, Daniel W.* "Enantiomeric Separation of Biaryl Atropisomers Using Cyclofructan Based Chiral Stationary Phases.” Journal of Chromatography A 2014, 1357, 172-181 (http://www.sciencedirect.com/science/article/pii/S0021967314006700#) Gao, Hongyin; Xu, Qing-Long; Ess, Daniel H. and Kürti, László*. "Transition-Metal-Free, Low-Temperature Intramolecular Amination of Aromatic C-H Bonds: Rapid Synthesis of Fused Heterocycles.” Angew. Chem. Int. Ed. 2014, 53, 2701-2705 (Hot Paper; http://onlinelibrary.wiley.com/doi/10.1002/anie.201309973/pdf). This article was featured in SYNFACTS 2014, 10(4), 0351 (https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0033-1341004). Jat, Jawahar L; Paudyal, Mahesh P.; Gao, Hongyin; Xu, Qing-Long; Yousufuddin, Muhammed.; Devarajan, Deepa; Ess, Daniel H*.; Kürti, László* and Falck, J.R.* ”Direct and Stereospecific Synthesis of Unprotected N-H and N-Me Aziridines from Olefins.” SCIENCE 2014, Vol 343, no 6166, p 61-65 (DOI:10.1126/science.1245727). This article was featured in Chemical and Engineering News on Jan 6th, 2014; C&EN Vol 92, Issue 1, p. 20-21 and in CHEMISTRY WORLD on Jan 9th, 2014; Title: “Simple route to add nitrogen to drugs”. It was highlighted as a SCIENCE Perspective. SCIENCE, 434, 33 (2014) in NATURE CHEMISTRY under the title “Protection not included” (Vol. 6, March 2014), Angew. Chem. Int. Ed.March 2014 “A Scalable Rhodium-Catalyzed Intermolecular Aziridination Reaction” and also in the blog “In the Pipeline” under the title “Easy Aziridines”.