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个人简介

广东省“特支计划”入选者,广州市“珠江科技新星”,2013年获得香港浸会大学博士学位;主持国家自然科学基金面上项目、青年项目,广东省自然科学基金项目、科技计划项目等。在包括PNAS, J. Am. Chem. Soc., ACS Nano等国际权威期刊上发表SCI论文20余篇,授权国家发明专利10项,美国专利1项。 工作经历 2013.08 - 2016.12 华南师范大学,生物光子学研究院,讲师 2017.01 - 2018.6.20 华南师范大学,生物光子学研究院,副研究员 2018.6.20-至今 华南师范大学,生物光子学研究院,特聘研究员 主持科研项目 广东省“特支计划”青年拔尖人才(2018) 广州市“珠江科技新星”(2018) 国家自然科学基金-面上项目(2017-2021) 国家自然科学基金-青年项目(2015-2017) 广东省自然科学基金-博士启动项目(2015-2017) 广东省教育厅青年创新人才项目(2015-2017)

研究领域

生物功能分子探针的开发及其在生物影像分析、肿瘤光学诊治中的应用基础研究等

主要从事生物功能分子探针的开发及其在生物影像分析、肿瘤光学诊治中的应用基础研究等

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230. 2. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497. 3. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120. 4. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943. 5. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938. 22. N. Wang, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst, Theranostics, 2021, 11, 2334-2348. 21. X. Jin#, Q. Zeng#, J. Zheng, D. Xing*, T. Zhang*, Aptamer-functionalized upconverting nanoformulations for light-switching cancer-specific recognition and in situ photodynamic–chemo sequential theranostics, ACS Appl. Mater. Interfaces, 2020, 10.1021/acsami.0c14730. 20. J. Zheng, Q. Zhan, L. Jiang, D. Xing, T. Zhang*, K.-L. Wong*, A bioorthogonal time-resolved luminogenic probe for metabolic labelling and imaging of glycans. Inorg. Chem. Front., 2020,7, 4062-4069. 19. X. Li, Y. Zhao, T. Zhang*, D. Xing*, Mitochondria-specific agents for photodynamic cancer therapy: A key determinant to boost the efficacy, Adv. Healthcare Mater. 2020, 2001240. 18. R. Zhang, J. Zheng, T. Zhang*, In vivo selective imaging of metabolic glycosylation with a tetrazine-modified upconversion nanoprobe, RSC Advances, 2020, 10, 15990 – 15996. 17. Y. Wu, J. Zheng, Q. Zeng, T. Zhang*, D. Xing*, Light-responsive charge-reversal nanovector for high-efficiency in vivo CRISPR/Cas9 gene editing with controllable location and time. Nano Research, 2020, 13, 2399–2406. 16. Y. Wu, J. Zheng, D. Xing*, T. Zhang*, Near-infrared light controlled fluorogenic labeling of glycoengineered sialic acids in vivo with upconverting photoclick nanoprobe. Nanoscale, 2020, 10361-10368. 2019 15. J. Zheng, Q. Zeng, R. Zhang, D. Xing*, T. Zhang*, Dynamic-reversible photoacoustic probe for continuous ratiometric sensing and imaging of redox status in vivo. J. Am. Chem. Soc. 2019, 141, 19226-29230. 14. J. Zheng, Y. Wu, D. Xing*, T. Zhang*, Synchronous detection of glutathione/hydrogen peroxide for monitoring redox status in vivo with a ratiometric upconverting nanoprobe. Nano Research, 2019, 12, 931-938. 13. Q. Zeng, R. Zhang, T. Zhang*, D. Xing*, H2O2-responsive biodegradable nanomedicine for cancer-selective dualmodal imaging guided precise photodynamic therapy, Biomaterials, 2019, 207, 39-48. 12. Y. Wu, G. Guo, J. Zheng, D. Xing*, T. Zhang*, Fluorogenic “photoclick” labeling and imaging of DNA with coumarin-fused tetrazole in vivo. ACS Sensors, 2019, 4, 44−51. 2016-2018 11. W. Fang, Y. Wei, Y. Ye, T. Zhang*, D. Xing*, Oxyhemoglobin-monitoring photodynamic theranostics with an 808 nmexcited upconversion optical nanoagent. Chemical Engineering J., 2018, 350, 108-119. 10. T. Ma, J. Zheng, T. Zhang*, D. Xing*, Ratiometric photoacoustic nanoprobes for monitoring and imaging of hydrogen sulfide in vivo. Nanoscale, 2018, 10, 13462-13470. 9. L. Du, H. Qin, T. Ma, T. Zhang*, D. Xing*, In vivo imaging-guided photothermal/photoacoustic synergistic therapy with bioorthogonal metabolic glycoengineering-activated tumor targeting nanoparticles. ACS Nano, 2017, 11, 8930−8943. 8. Q. Ding, Q. Zhan, X. Zhou, T. Zhang*, D. Xing*, Theranostic upconversion nanobeacons for tumor mRNA ratiometric fluorescence detection and imaging-monitored drug delivery. Small, 2016, 12, 5944.(Front Cover) Before 2015 7. T. Zhang, R. Lan, L. Gong, B. Wu, Y. Wang, D. W. J. Kwong, W.-K. Wong, K.-L. Wong,* D. Xing*, An amphiphilic BODIPY-porphyrin conjugate: intense two-photon absorption and rapid cellular uptake for two-photon-induced imaging and photodynamic therapy, ChemBioChem, 2015, 16, 2357 – 2364. (Back Cover) 6. T. Zhang, R. Lan, C.-F. Chan, G.-L. Law, W.-K. Wong*, K.-L. Wong*, In vivo selective cancer-tracking gadolinium eradicator as new-generation photodynamic therapy agent, PNAS, 2014, 111, E5492-E5497. 5. T. Zhang, C.-F. Chan, R. Lan, W.-K. Wong, K.-L. Wong, Highly selective and responsive visible to near-IR ytterbium emissive probe for monitoring mercury(II), Chem. Eur. J. 2014, 20, 970 – 973 4. T. Zhang, C.-F. Chan, R. Lan, P.-S. Chan, N.-K. Mak, W.-K. Wong*, K.-L. Wong*, Selective differentiation of cancer cells by porphyrin-based ytterbium complexes targeting anionic phospholipid membrane. Chem. Commun., 2013, 49, 7252-7254. 3. T. Zhang, X. Zhu, W.-K. Wong*, H.-L. Tam, W.-Y. Wong*, Light-harvesting ytterbium (III)-porphyrinate-BODIPY conjugates: synthesis, excitation-Energy transfer, and two-photon-induced near-infrared-emission studies. Chem. Eur. J., 2013, 19, 739-748. 2. T. Zhang, C.-F. Chan, J. Hao, G.-L. Law, W.-K. Wong*, K.-L. Wong*, Fast uptake, water-soluble, mitochondria-specific erbium complex for a dual function molecular probe – imaging and photodynamic therapy. RSC Advances, 2013, 3, 382-385. 1. T. Zhang, X. Zhu, C. C. W. Cheng, W.-M. Kwok, H.-L. Tam, J. Hao, D. W. J. Kwong, W.-K. Wong*, K.-L. Wong*, Water-soluble mitochondria-specific ytterbium complex with impressive NIR emission. J. Am. Chem. Soc., 2011, 133, 20120.

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