刘镭 - 华南师范大学 - 脑科学与康复医学研究所

个人简介

发表研究论文 30 余篇，多篇论文发表在 International Journal of Cancer, Cell Death and Disease, Free Radical Biology & Medicine, Antioxidants & Redox Signaling，Molecular Biology of The Cell, Cellular Signaling等国际知名学术期刊上。研究成果受到国内外同行的广泛关注，重要的研究成果被 Nature Reviews Cancer, Nature Chemical Biology, Genes &Development, Blood, Cancer Research 等权威学术期刊多次引用。教育及工作经历 2004.09-2009.06 华南师范大学博士 2009.07-2011.12 华南师范大学生物光子学研究院讲师 2012.01-2014.12 墨尔本大学博士后 2015.01-2018.04 华南师范大学生物光子学研究院副研究员 2018.04-至今华南师范大学脑科学与康复医学研究院副研究员主持科研项目国家自然科学基金面上项目（基金号：31470072）；国家自然科学基金青年基金项目（基金号：31101028）；广东省自然科学基金自由申请项目（基金号：2014A030313419）获奖 2010.03，与所在研究团队一起获得广东省科学技术奖二等奖。获奖项目名称：光学与生命科学交叉科学中的前沿问题与关键技术研究。

研究领域

主要从事生物医学方向的基础科研工作：1. 细胞凋亡与肿瘤、帕金森症、老年痴呆等重大慢性疾病的密切关联；2. 线粒体功能紊乱在肿瘤、老年痴呆等重大疾病的预防与治疗中的作用；3. 先进的光学成像技术在生命科学中的应用；4. 中枢神经系统的发育与再生机制研究。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Li Haolong, Lei Liu, Haocai Chang, Zou, Da Xing, “Downregulation of MCL-1 and upregulation of PUMA using mTOR inhibitors enhance antitumor efficacy of BH3 mimetics in triple-negative breast cancer.” Cell Death and Disease, 2018, 9: (137),1-15. (Corresponding author). 2. Xiaotong Gu, Lei Liu, Qi Shen, Da Xing, “Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP+-induced neuronal injury in a cellular model of Parkinson's disease”, Cellular Signalling, 37, 103-114, 2017. (Corresponding author) 3. Xianwang Wang, S. Hu, Lei Liu, “Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically?” Oncol. Lett. 13(5), 2867-2872, 2017. (Corresponding author) 4. 常好才, 张真真，刘镭，“低功率光照疗法对机体免疫应答的影响” 生物化学与生物物理进展. 44（12）1074-1082，2017. (Corresponding author) 5. Zhenzhen Zhang, Lei Liu, Shengnan Wu, Da Xing. “Drp1, Mff, Fis1, and MiD51 are coordinated to mediate mitochondrial fission during UV irradiation–induced apoptosis”, FASEB J, 30, 466-476, 2016. 6. Zhenzhen Zhang, Lei Liu, Xiaoxiao Jiang, Shaodong Zhai, Da Xing. “The Essential Role of Drp1 and Its Regulation by S-Nitrosylation of Parkin in Dopaminergic Neurodegeneration: Implications for Parkinson’s Disease”, Antioxidants & Redox Signaling, 25(11), 609-622, 2016. 7. Cuixia Lu, Feifan Zhou, Shengnan Wu, Lei Liu, Da Xing. “Phototherapy-induced antitumor immunity: long-term tumor suppression effects via photoinactivation of respiratory chain oxidase-triggered superoxide anion burst. Antioxidants & Redox Signaling, 24(5), 249-262, 2016. 8. Jie Feng, Qinyan Sun, Lei Liu and Da Xing, Photoactivation of TAZ induces osteogenic differentiation via Akt/GSK3β signaling pathway, Int. J. Biochem. Cell Biol., 66, 59-68, 2015. 9. Jiangang Liang, Lei Liu, and Da Xing, “Photobiomodulation by low power laser irradiation attenuates Aβ-induced cell apoptosis through Akt/GSK-3β/β-catenin pathway”, Free Radic. Biol. Med., 53(7), 1459-1467, 2012. 10. Lei Liu, Zhen-Zhen Zhang, and Da Xing, “Activation of Bax by lysosomal photodamage induces cell death via mitochondrial apoptotic pathway”, Free Radic. Biol. Med., 51, 53-68, 2011. 11. Hui Li, Lei Liu, and Da Xing, Wei R. Chen, “Inhibition of JNK/Bim pathway by HSP70 prevents Bax activation in UV-induced apoptosis”, FEBS Lett., 584, 4672-4678, 2010. 12. Lei Liu, Da Xing, and Wei R. Chen, “μ-Calpain mediates caspase-dependent and-independent apoptotic pathways in cisplatin-induced apoptosis”, Int. J. Cancer, 125, 2757-2766, 2009. 13. Lei Liu, Yingjie Zhang, Xianwang Wang, “Using FRET technique to investigate the apoptotic mechanism induced by cisplatin in living cells”, Prog. Biochem. Biophys. 36 (9), 1172-1176, 2009. 14. Yingjie Zhang, Da Xing, and Lei Liu, “PUMA promotes Bax translocation by both directly activating Bax and antagonizing Bcl-XL during UV-induced apoptosis”, Mol. Biol. Cell, 3077-3087, 2009. 15. Xuejuan Gao, Da Xing, Lei Liu, and Yonghong Tang, “H-Ras and PI3K are required for the formation of circular dorsal ruffles induced by low power laser irradiation”, J. Cell. Physiol., 219, 535-543, 2009.