Bruick, Richard - UT Southwestern Medical Center

个人简介

Undergraduate University of North Carolina at Chapel Hill (1991), Chemistry Graduate School Scripps Research Institute (1998), Biology

研究领域

Cancer Cellular sensors of environmental and metabolic cues Regulation of mammalian iron homeostasis Regulation of mammalian oxygen homeostasis

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK Nat. Chem. Biol. 2013 Apr 9 4 271-6 F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis. Ruiz JC, Walker SD, Anderson SA, Eisenstein RS, Bruick RK J. Biol. Chem. 2013 Jan 288 1 552-60 The hemerythrin-like domain within F-box and leucine-rich repeat protein 5 communicates cellular iron and oxygen availability by distinct mechanisms. Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK The Journal of biological chemistry 2012 May Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). Thompson JW, Salahudeen AA, Chollangi S, Ruiz JC, Brautigam CA, Makris TM, Lipscomb JD, Tomchick DR, Bruick RK J. Biol. Chem. 2012 Mar 287 10 7357-65 An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Salahudeen AA, Thompson JW, Ruiz JC, Ma HW, Kinch LN, Li Q, Grishin NV, Bruick RK Science 2009 Oct 326 5953 722-6 FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK Genes Dev. 2002 Jun 16 12 1466-71 A conserved family of prolyl-4-hydroxylases that modify HIF. Bruick RK, McKnight SL Science 2001 Nov 294 5545 1337-40 Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH ACS Chem. Biol. 2013 Mar 8 3 626-35 Development of inhibitors of the PAS-B domain of the HIF-2a transcription factor. Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK J. Med. Chem. 2013 Feb 56 4 1739-47 Protein degradation and iron homeostasis. Thompson JW, Bruick RK Biochim. Biophys. Acta 2012 Sep 1823 9 1484-90 Activation of the HIF prolyl hydroxylase by the iron chaperones PCBP1 and PCBP2. Nandal A, Ruiz JC, Subramanian P, Ghimire-Rijal S, Sinnamon RA, Stemmler TL, Bruick RK, Philpott CC Cell Metab. 2011 Nov 14 5 647-57 Conditional HIF-1alpha expression produces a reversible cardiomyopathy. Bekeredjian R, Walton CB, MacCannell KA, Ecker J, Kruse F, Outten JT, Sutcliffe D, Gerard RD, Bruick RK, Shohet RV PLoS ONE 2010 5 7 e11693 Maintaining Mammalian iron and oxygen homeostasis: sensors, regulation, and cross-talk. Salahudeen AA, Bruick RK Ann. N. Y. Acad. Sci. 2009 Oct 1177 30-8 Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH Proc. Natl. Acad. Sci. U.S.A. 2009 Jan 106 2 450-5 JMJD6 is a histone arginine demethylase. Chang B, Chen Y, Zhao Y, Bruick RK Science 2007 Oct 318 5849 444-7 Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. Nguyen AD, McDonald JG, Bruick RK, DeBose-Boyd RA J. Biol. Chem. 2007 Sep 282 37 27436-46 Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one? Ozer A, Bruick RK Nat. Chem. Biol. 2007 Mar 3 3 144-53 Hypoxia-inducible factors Per/ARNT/Sim domains: structure and function. Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK Meth. Enzymol. 2007 435 3-24 Dioxygenases as O2-dependent regulators of the hypoxic response pathway. Dann CE, Bruick RK Biochem. Biophys. Res. Commun. 2005 Dec 338 1 639-47 Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor. Yang J, Zhang L, Erbel PJ, Gardner KH, Ding K, Garcia JA, Bruick RK J. Biol. Chem. 2005 Oct 280 43 36047-54