Hu, Dehong - Pacific Northwest National Laboratory -

个人简介

Dr. Dehong Hu is a Chemist with the Molecular Bioimaging and Cellular Dynamics team in PNNL’s Environmental Molecular Sciences Division and the Environmental Molecular Sciences Laboratory (EMSL) user program. He has more than 20 years of experience in single molecule fluorescence imaging and has coauthored more than 100 publications, including publications in Nature, Science, and PNAS. Education PhD in Chemistry, University of Minnesota MS in Chemistry, Peking University BS in Chemistry, Peking University

研究领域

Hu works with EMSL users on multiple proposals involving fluorescence in situ hybridization, single-molecule imaging, and single cell analysis. He maintains and develops super resolution microscopes and participates in the U.S. Department of Energy, Office of Science, Biological and Environmental Research program’s bioimaging project.

近期论文

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Liu W., L. Huang, R.E. Komorek, P. Handakumbura, Y. Zhou, D. Hu, and M.H. Engelhard, et al. 2020. "Correlative Surface Imaging Reveals Chemical Signatures for Bacterial Hotspots on Plant Roots." Analyst 145, no. 2:393-401. PNNL-SA-149225. doi:10.1039/C9AN01954E Mao J., Y. Kim, Y. Zhou, D. Hu, C. Zhong, H. Chang, and C.J. Brislawn, et al. 2020. "Genetic and Metabolic Links Between the Murine Microbiome and Memory." Microbiome 8, no. 1:Article No. 53. PNNL-SA-143770. doi:10.1186/s40168-020-00817-w Mao, J. H., Y. M. Kim, Y. X. Zhou, D. Hu, C. Zhong, H. Chang, C. J. Brislawn, S. Fansler, S. Langley, Y. Wang, B. Y. L. Peisl, S. E. Celniker, D. W. Threadgill, P. Wilmes, G. Orr, T. O. Metz, J. K. Jansson, and A. M. Snijders. 2020. “Correction To: Genetic and Metabolic Links between the Murine Microbiome and Memory (Microbiome (2020) 8:53 Doi: 10.1186/S40168-020-00817-W).” Microbiome 8 (1). doi.org/10.1186/s40168-020-00870-5. Mensch A.C., E.S. Melby, E. Laudadio, I.U. Foreman-Ortiz, Y. Zhang, A. Dohnalkova, and D. Hu, et al. 2020. "Preferential interactions of primary amine-terminated quantum dots with membrane domain boundaries and lipid rafts revealed with nanometer resolution." Environmental Science Nano 7, no. 1:149-161. PNNL-SA-146870. doi:10.1039/C9EN00996E Taylor S.E., C.I. Pearce, K.A. Sanguinet, D. Hu, W.B. Chrisler, Y. Kim, and Z. Wang, et al. 2020. "Polystyrene Nano- and Microplastic Accumulation at Arabidopsis and Wheat Root Cap Cells, but No Evidence for Uptake into Roots." Environmental Science: Nano 7, no. 7:1942-1953. PNNL-SA-147042. doi:10.1039/d0en00309c Cui Y., E.S. Melby, A.C. Mensch, E. Laudadio, M. Hang, A. Dohnalkova, and D. Hu, et al. 2019. "Quantitative mapping of oxidative stress response to lithium cobalt oxide nanoparticles in single cells using multiplexed in situ gene expression analysis." Nano Letters 19, no. 3:1990-1997. PNNL-SA-140489. doi:10.1021/acs.nanolett.8b05172 Weber, T. J., W. J. Qian, J. N. Smith, M. A. Gritsenko, D. Hu, W. B. Chrisler, and C. Timchalk. 2019. “Stable Acinar Progenitor Cell Model Identifies Treacle-Dependent Radioresistance.” Radiation Research 192 (2): 135-144. doi.org/10.1667/RR15342.1. Yang X., R. Parashar, N. Sund, A.E. Plymale, T.D. Scheibe, D. Hu, and R.T. Kelly. 2019. "On Modeling Ensemble Transport of Metal Reducing Motile Bacteria." Scientific Reports 9. PNNL-SA-134947. doi:10.1038/s41598-019-51271-0 Zhang J., D. Hu, G. Orr, and J.S. Schilling. 2019. "Fluorescence In Situ mRNA Hybridization for Gene Expression Detection in a Wood Decay Fungus." International Biodeterioration & Biodegradation 143. PNNL-SA-140382. doi:10.1016/j.ibiod.2019.104731 Cui, Y., D. Hu, L. M. Markillie, W. B. Chrisler, M. J. Gaffrey, C. Ansong, L. Sussel, and G. Orr. 2018. “Fluctuation Localization Imaging-Based Fluorescence in Situ Hybridization (fliFISH) for Accurate Detection and Counting of RNA Copies in Single Cells.” Nucleic Acids Research 46 (2). doi.org/10.1093/nar/gkx874. Jiao S., X. Ren, R. Cao, M.H. Engelhard, Y. Liu, D. Hu, and D. Mei, et al. 2018. "Stable Cycling of High-Voltage Lithium Metal Batteries in Ether Electrolytes." Nature Energy 3, no. 9:739-746. PNNL-SA-131449. doi:10.1038/s41560-018-0199-8 Li X., J. Tao, D. Hu, M.H. Engelhard, W. Zhao, J. Zhang, and W. Xu. 2018. "Stability of Polymeric Separators in Lithium Metal Batteries in a Low Voltage Environment." Journal of Materials Chemistry A 6, no. 12:5006-5015. PNNL-SA-131076. doi:10.1039/C7TA11259A Olenick L.L., J. Troiano, A.M. Vartanian, E.S. Melby, A.C. Mensch, L. Zhang, and J. Hong, et al. 2018. "Lipid Corona Formation from Nanoparticle Interactions with Bilayers." Chem 4, no. 11:2709-2723. PNNL-SA-138886. doi:10.1016/j.chempr.2018.09.018 Proetto M.T., C.E. Callmann, J.B. Cliff, C.J. Szymanski, D. Hu, S.B. Howell, and J.E. Evans, et al. 2018. "Tumor Retention of Enzyme-Responsive Pt(II) Drug-Loaded Nanoparticles Imaged by Nanoscale Secondary Ion Mass Spectrometry and Fluorescence Microscopy." ACS Central Science 4, no. 11:1477-1484. PNNL-SA-138579. doi:10.1021/acscentsci.8b00444 Varga T., T.C. Droubay, L. Kovarik, D. Hu, and S.A. Chambers. 2018. "Controlling the structure and ferroic properties of strained epitaxial NiTiO3 thin films on sapphire by post-deposition annealing." Thin Solid Films 662. PNNL-SA-129160. doi:10.1016/j.tsf.2018.07.030 Duan W., V.S. Vemuri, D. Hu, Z. Yang, and X. Wei. 2017. "A Protocol for Electrochemical Evaluation and State of Charge Diagnostics of A Symmetric Organic Redox Flow Battery." Journal of Visualized Experiments. PNNL-SA-118931. doi:10.3791/55171 Lemmer K.C., W. Zhang, S.J. Langer, A. Dohnalkova, D. Hu, R.A. Lemke, and J.S. Piotrowski, et al. 2017. "Mutations that alter the bacterial cell envelope increase lipid production." mBio 8, no. 3:Article No. e00513-17. PNNL-SA-125854. doi:10.1128/mBio.00513-17 Mobberley J.M., S.R. Lindemann, H.C. Bernstein, J.J. Moran, R.S. Renslow, J.T. Babauta, and D. Hu, et al. 2017. "Organismal and spatial partitioning of energy and macronutrient transformations within a hypersaline mat." FEMS Microbiology Ecology 93, no. 4:Article No. fix028. PNNL-SA-124562. doi:10.1093/femsec/fix028 Novikova I.V., C.R. Smallwood, Y. Gong, D. Hu, L. Hendricks, J.E. Evans, and A. Bhattarai, et al. 2017. "Multimodal Hyperspectral Optical Microscopy." Chemical Physics 498-499. PNNL-SA-120193. doi:10.1016/j.chemphys.2017.08.011 Varga T., T.C. Droubay, L. Kovarik, M.I. Nandasiri, V. Shutthanandan, D. Hu, and B. Kim, et al. 2017. "Coupled Lattice Polarization and Ferromagnetism in Multiferroic NiTiO3 Thin Films." ACS Applied Materials & Interfaces 9, no. 26:21879-21890. PNNL-SA-121771. doi:10.1021/acsami.7b04481 Wang Y., Z. Li, M. Liu, D. Hu, Y. Lin, and J. Li. 2017. "Multiple-Targeted Graphene-based Nanocarrier for Intracellular Imaging of mRNAs." Analytica Chimica Acta 983. PNNL-SA-126440. doi:10.1016/j.aca.2017.07.017