闫爱新 - 香港大学 - 生物科学学院

个人简介

Awards and Honors (selected): Young Investigator’s Award, Hong Kong Society of Immunology, 2013. Best Oral Presentation Award, The Annual Scientific Meeting of the Hong Kong Society of Immunology, Hong Kong, May 25, 2013. Federation of European Microbiological Societies (FEMS) Young Scientist Meeting Grant, "7th European Workshop on Bacterial Respiratory Chains", Backagården, Höör, Lund, Sweden, 2011. HKU Overseas Fellowship Award, HKU, 2010. Poster-Presentation Award at the Kenneth B. Raper Symposium for Microbiology, University of Wisconsin-Madison, Madison, WI, USA, August 31, 2007. Traveling Award for the 11th EMBO-FEBS Advanced Lecture Course on "Molecular and Cellular Biology of Membranes", June 18-29, Corsica, France, 2007. Traveling Award for the US-Japan Glyco 2004, November 17-21, Honolulu, Hawaii, USA, 2004. Traveling Award for the IUBMB/ASBMB 2004 meeting, June 12-16, Boston, MA,USA, 2004. Excellent graduate student, Peking University, Beijing, China, 2001. Excellent Young Scientist Award in the Peptide Field bestowed by the 6th Chinese International Peptide Symposium (CPS), July, Mount Huang, China, 2000.

研究领域

Microbial Stress Response and AMR. Pathogens undergo extensive physiological changes during the transition from their natural habitats to the human host. We investigate the underlying signal transduction pathways and the emergence of antimicrobial resistance (AMR) during this process. We have shown that the chromosomal resistance genes encoding the multidrug efflux pump MdtEF is up-regulated during anaerobic adaptation in E. coli to protect the bacterium from nitrosative stress. This and evidence from others suggests that AMR determinants such as efflux pumps have extensive physiological roles in bacteria, especially during the stress response. We aim to uncover the molecular mechanisms underlying the link of stress response and emergence of AMR in the common Gram-negative pathogens E. coli, S. Typhimurium, P. aeruginosa (In collaboration with Prof. Kunihiko Nishino, Osaka University).

近期论文

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Xiao T, Yan A, Huang J, Jorgensen E, Shah N, Comparative Peptidomic and Meta-transcriptomic Analyses Reveal Improved Gamma-amino butyric acid Production Machinery in Levilactobacillus brevis NPS-QW 145 Co-cultured with Streptococcus thermophilus ASCC1275 during Milk Fermentation, Appl. Environ. Microbiol. 2020, DOI: 10.1128/AEM.01985-20 Wang H, Yang X, Wang M, Hu M, Xu X, Yan A, Hao Q, Li H, Sun H, Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm, Chemical Sciences 2020, doi:10.1039/d0sc04151c Sun H, Wang R, Zang Q, Wang H, Wong YT, Wang M, Hao Q, Yan A, Kao RYT, Ho PL, Li H, Resensitizing carbapenem- and colistin-resistant bacteria to antibiotics using auranofin, Nature Communications 2020;11(1):5263, doi: 10.1038/s41467-020-18939-y. Wang X, Zhang Y, Ren M, Xia T, Chu X, Liu C, Lin X, Huang Y, Chen Z, Yan A, Luo H, Cryptic Speciation of a Pelagic Roseobacter Population Varying at a Few Thousand Nucleotide Sites, The ISME Journal 2020, doi:10.1038/s41396-020-00743-7 Xu Z, Li Y, Li M, Xiang H, Yan A*, Harnessing the native CRISPR-Cas systems for genome editing in prokaryotes, Environ. Microbiol. 2020, doi: 10.1111/1462-2920.15116. Xu Z, Li Y, Yan A* Repurposing the native type I-F CRISPR-Cas system in P. aeruginosa for genome editing, Star Protocol 2020, 1: 100039 doi:10.1016/j.xpro.2020.100039. Xu Z, Wang P, Wang H, Yu ZH, Au-Yeung HY, Hirayama T, Sun H, Yan A* Zinc excess increases cellular demand for iron and decreases tolerance to copper in Escherichia coli, J. Biol. Chem 2019, 294(45) 16978-16991. Xu Z, Li M, Li Y, Cao H, Miao L, Xu Z, Higuchi Y, Yamasaki S, Nishino K, Woo PCY, Xiang H, Yan A*, Native CRISPR-Cas-mediated genome editing enables dissecting and sensitizing clinical multidrug resistant P. aeruginosa, Cell Rep. 2019, 29 1707-1717. Wang H, Wang M, Yang X, Xu X, Hao Q, Yan A, Hu M, Lobinski R, Li H, Sun H, Antimicrobial Silver Targets Glyceraldehyde-3-phosphate Dehydrogenase in Glycolysis of E. coli, Chem. Sci 2019, 10, 7193-7199. DOI: 10.1039/c9sc02032b. Wang H, Yan A, Liu Z, Yang X, Xu Z, Wang Y, Wang R, Koohi-Moghadam M, Hu L, Xia W, Tang H, Wang Y, Li H, Sun H., Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli, PLoS Biol 2019,17(6): e3000292. Wang Z.#, Sun J.#, Tian M.#, Xu Z., Liu Y., Fu, J., Yan A*, Liu, X*, Proteomic analysis of FNR-regulated anaerobiosis in Salmonella Typhimurium, Journal of The American Society for Mass Spectrometry 2019, Vol. 30 DOI: 10.1007/s13361-019-02145-2 Long S, Miao L, Li R, Deng F, Qiao Q, Liu X, Yan A, Xu Z, Rapid Identification of Bacteria by Differential Emissions of a Transformable Fluorescent Sensor, ACS sensors 2019, 4, 281-285 Cao H, Xia T, Li Y, Xu Z, Bougouffa S, Lo YT, Bajic V, Luo H, Woo, PCY, Yan A*, uncoupled quorum sensing modulates the interplay of virulence and resistance in a multidrug resistant clinical P. aeruginosa isolate belong to the MLST550 clonal complex, Antimicrobial Agents and Chemotherapy, 2019, 63 (4), e01944-18. doi: 10.1128/AAC.01944-18 Andolina G, Wei R, Liu H, Yang X, Cao H, Chen S, Yan A, Li XD, Li X, Metabolic Labeling of Pseudaminic Acid-containing Glycans on Bacterial Surfaces, ACS Chemical Biology 2018; 13(10):3030-3037, doi: 10.1021/acschembio.8b00822. Wang Z, Sun J, Xia T, Liu Y, Fu J, Lo Y., Chang C, Yan A*, Liu X*, Proteomic delineation of the ArcA regulon in Salmonella Typhimurium during anaerobiosis, Molecular ＆Cellular Proteomics 2018; 17(10):1937-1947, doi: 10.1074/mcp.RA117.000563. Heshiki1 Y, Dissanayake1 T, Zheng T, Kang K, Ni Y, Xu Z, Sarkar C, Woo CY, Chow K. C. Chow, Baker D, Yan A, Webster C, Panagiotou G*, Li J Toward a Metagenomic Understanding on the Bacterial Composition and Resistome in Hong Kong Banknotes, Frontiers in Microbiology 2017 doi: 10.3389/fmicb.2017.00632 Neelakantan P *, Romero M, Vera J, Daood U, Khan A, Yan A., Cheung G, Biofilms in Endodontics - Current Status and Future Directions, International Journal of Molecular Sciences 2017; 18, 1748; doi:10.3390/ijms18081748 Cao H*, Lai Y, Bougouffa S, Xu Z, Yan A.* Comparative genome and transcriptome analysis reveals distinctive surface characteristics and unique physiological potentials in Pseudomonas aeruginosa ATCC 27853, BMC Genomics 2017; 18:459 doi: 10.1186/s12864-017-3842-z. Lai Y, Xu Z, Yan A. *A novel regulatory circuit to control indole biosynthesis protects Escherichia coli from nitrosative damages during the anaerobic respiration of nitrate, Environmental Microbiology 2017; 19: 598-610 Gan R, Deng Z, Yan A, Shah NP, Lui WY, Chan CL, Corke H, Pigmented edible bean coats as natural sources of polyphenols with antioxidant and antibacterial effects, Food Science and Technology 2016; 73, 168-177