Luo, Jinghui - Paul Scherrer Institute -

个人简介

2017.07-now: Principal Investigator, Paul Scherrer Institute, Switzerland 2014.12-2017.06: Research Fellow, Oxford University, UK 2014.06: PhD, Leiden University, the Netherlands 2009.06-2009.12: Traineeship, EMBL, Germany 2009.06: MSc, Uppsala University, Sweden

研究领域

1. Structural and biophysical characterization of amyloid proteins 2. Single-channel electrical and optical studies of ion channel, amyloid and other membrane proteins in the lipid bilayer

近期论文

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Cryo-electron microscopy imaging of Alzheimer's amyloid-beta 42 oligomer displayed on a functionally and structurally relevant scaffold Wu J, Blum TB, Farrell DP, DiMaio F, Abrahams JP, Luo J. Angew Chem Int Ed Engl . 2021 May 27.DOI:10.1002/anie.202104497. ATP Impedes the Inhibitory Effect of Hsp90 on Aβ40 Fibrillation Wang H , Lallemang M , Hermann B , Wallin C , Loch R, Blanc A, Balzer BN, Hugel T, Luo J Journal of Molecular Biology 433 (2), 166717 (2021).DOI:10.1016/j.jmb.2020.11.016 Antimicrobial Peptide Mimetics Based on a Diphenylacetylene Scaffold: Synthesis, Conformational Analysis, and Activity Peacock H, Henriques ST, Benfield AH, Elliott AG, Luo J, J Luccarelli, Nagano M, Craik D, Hamilton A ChemMedChem. 15 (20), 1932-1939 (2020).DOI: 10.1002/cmdc.202000474 Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives Wu J, Cao C, Loch RA, Tiiman A, Luo J Quarterly Reviews of Biophysics. 53:e12 (2020).DOI: 10.1017/S0033583520000086 Nuclear Pore Membrane Proteins Self-Assemble into Nanopores Panatala R, Barbato S, Kozai T, Luo J, Kapinos Larisa E, Lim Roderick YH BIOCHEMISTRY 58, 484 (2019). DOI: 10.1021/acs.biochem.8b01179 Membrane-mimetic systems for biophysical studies of the amyloid-? peptide Österlund N, Luo J, Wärmländer Sebastian KTS, Gräslund A BIOCHIMICA ET BIOPHYSICA ACTA (BBA) - PROTEINS AND PROTEOMICS , S1570963918302036 (2018). DOI: 10.1016/j.bbapap.2018.11.005 The Neuronal Tau Protein Blocks in Vitro Fibrillation of the Amyloid-? (A?) Peptide at the Oligomeric Stage Wallin C, Hiruma Y, Wärmländer SKTS, Huvent I, Jarvet J, Abrahams J, Gräslund A, Lippens G, Luo J JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140, 8138 (2018). DOI: 10.1021/jacs.7b13623 Alzheimer?s disease and cigarette smoke components: effects of nicotine, PAHs, and Cd(II), Cr(III), Pb(II), Pb(IV) ions on amyloid-? peptide aggregation Wallin C, Sholts Sabrina B, Österlund N, Luo J, Jarvet J, Roos Per M, Ilag L, Gräslund A, Wärmländer Sebastian KTS Scientific Reports 7, 14423 (2017). DOI: 10.1038/s41598-017-13759-5 Maleimido-proxyl as an EPR spin label for the evaluation of conformational changes of albumin Pavicevic A, Luo J, Popovic-Bijelic A, Mojovic M European Biophysics Journal 46, 773 (2017). DOI: 10.1007/s00249-017-1257-z Characterization of Mn(II) ion binding to the amyloid-? peptide in Alzheimer?s disease Wallin C, Kulkarni Yashraj S, Abelein A, Jarvet J, Liao Q, Strodel B, Olsson L, Luo J, Abrahams J, Sholts Sabrina B, Roos Per M, Kamerlin Shina CL, Gräslund A, Wärmländer Sebastian KTS JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY , (2016). DOI: 10.1016/j.jtemb.2016.03.009 Coupled commensurate charge density wave and lattice distortion in Na2Ti2Pn2O(Pn=As,Sb) determined by x-ray diffraction and angle-resolved photoemission spectroscopy Davies NR, Johnson RD, Princep AJ, Gannon LA, Ma JZ, Qian T, Richard P, Li H, Shi M, Nowell H, Baker PJ, Shi YG, Ding H, Luo J, Guo YF, Boothroyd AT PHYSICAL REVIEW B 94, 104515 (2016). DOI: 10.1103/PhysRevB.94.104515 Cross-interactions between the Alzheimer Disease Amyloid-? Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J JOURNAL OF BIOLOGICAL CHEMISTRY 291, 16485 (2016). DOI: 10.1074/jbc.R116.714576 Non-covalent S?O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation Peacock H, Luo J, Yamashita T, Luccarelli J, Thompson S, Hamilton Andrew D CHEMICAL SCIENCE 7, 6435 (2016). DOI: 10.1039/C6SC00756B Reciprocal Molecular Interactions between the A? Peptide Linked to Alzheimer?s Disease and Insulin Linked to Diabetes Mellitus Type II Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J ACS Chemical Neuroscience 7, 269 (2016). DOI: 10.1021/acschemneuro.5b00325 Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species Tiiman A, Luo J, Wallin C, Olsson L, Lindgren J, Jarvet J, Per R, Sholts Sabrina B, Rahimipour S, Abrahams J, Karlström A, Gräslund A, Wärmländer Sebastian KTS Journal of Alzheimer's Disease 54, 971 (2016). DOI: 10.3233/JAD-160427 The Amyloid-? Peptide in Amyloid Formation Processes: Interactions with Blood Proteins and Naturally Occurring Metal Ions Wallin C, Luo J, Jarvet J, Wärmländer Sebastian KTS, Gräslund A ISRAEL JOURNAL OF CHEMISTRY 57, 674 (2016). DOI: 10.1002/ijch.201600105 Alzheimer Peptides Aggregate into Transient Nanoglobules That Nucleate Fibrils Luo J, Wärmländer Sebastian KTS, Gräslund A, Abrahams J BIOCHEMISTRY 53, 6302 (2014). DOI: 10.1021/bi5003579 ChemInform Abstract: Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J ChemInform 45, no (2014). DOI: 10.1002/chin.201422265 Cyclic Peptides as Inhibitors of Amyloid Fibrillation Luo J, Abrahams J CHEMISTRY - A EUROPEAN JOURNAL 20, 2410 (2014). DOI: 10.1002/chem.201304253 Endogenous Polyamines Reduce the Toxicity of Soluble A? Peptide Aggregates Associated with Alzheimer?s Disease Luo J, Mohammed I, Wärmländer Sebastian KTS, Hiruma Y, Gräslund A, Abrahams J BIOMACROMOLECULES 15, 1985 (2014). DOI: 10.1021/bm401874j