Chang, Wei-Chen - North Carolina State University

个人简介

Background B.S., National Taiwan University, 1999-2003 Ph.D., University of Texas at Austin, 2005-2011 Postdoctoral Research Fellow, The Pennsylvania State University, 2011-2015 Awards 2022, Goodnight Early Career Innovator 2020, ACS Academic Young Investigator (Division of Organic Chemistry) 2020, Harry C. Kelly Memorial Fund for U.S.-Japan Scientific Cooperation, NC Japan Center 2019, Faculty Early Career Development Program (CAREER) Award: National Science Foundation 2016, Faculty Research and Professional Development Program Award, North Carolina State University 2015, Founders Award for the 24th Enzyme Mechanisms Conference 2010-2011, Vice President of Pharmacy Graduate Student Association, College of Pharmacy, University of Texas at Austin 2009, Dr. Jerry and Joan Fineg Student Professional Development Endowment. Austin, TX. 2008-2010, Jaime N. Delgado Endowed Graduate Fellowship 2003, National Science Council Undergraduate Fellowship, Taiwan

研究领域

I. Chemo-enzymatic Preparation of natural products II. Mechanistic Investigation of Enzyme-Catalyzed Transformations

近期论文

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L Cha, JC Paris, B Zanella, M Spletzer, A Yao, Y Guo, W-c Chang. 2023. Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes. JACS. 10.1021/jacs.2c12664 W Kim, TY Chen, L Cha, G Zhou, K Xing, NK Canty, Y Zhang, W-c Chang. 2022. Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate. Nat. Commun. 13: 5343. X Li, S Xue, Y Guo, W-c Chang. 2022. Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation. J. Am. Chem. Soc. 144:8257-8266. TY Chen, Z Zheng, X Zhang, J Chen, L Cha, Y Tang, Y Guo, J Zhou, B Wang, H-w Liu, W-c Chang. 2022. Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis. ACS Catal. 12: 2270–2279. X Li, R Shimaya, T Dairi, W-c Chang, Y Ogasawara. 2022. Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes. Angew. Chem. Int. Ed. 61:e202113189 H Tang, MH Wu, HY Lin, MR Han, YH Tu, ZI Yang, TC Chien, NL Chan, W-c Chang. 2022. Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase. PNAS. 119:e2113770119. OM Manley, H Tang, S Xue, Y Guo, W-c Chang, TM Makris. 2021. BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate. J. Am. Chem. Soc. 143:21416-21424. TY Chen, W-c Chang. 2021. A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase. Proc. Natl. Acad. Sci. U.S.A. 118: e2109992118 H Tang, Y Tang, IV Kurnikov, H-J Liao, N-L Chan, MG Kurnikova, Y Guo, W-c Chang. 2021. Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones. ACS Catalysis. 11: 7186–7192 (Editor’s choice; Front cover) TY Chen, S Xue, WC Tsai, TC Chien, Y Guo, W-c Chang. 2021. Deciphering Pyrrolidine and Olefin Formation Mechanism in Kainic Acid Biosynthesis. ACS Catalysis 11: 278-282 (Front Cover) L Cha, W-c Chang. 2020. An Effective Strategy to Introduce Carbon Isotopes by Simple Swaps of CO2. Trends in Chemistry. 2 (12), 1040-1042 L Cha, S Milikisiyants, M Davidson, S Xue, T Smirnova, AI Smirnov, Y Guo, W-c Chang. 2020. Alternative reactivity of leucine 5-hydroxylase using an olefin-containing substrate to construct substituted piperidine ring. Biochemistry. 59(21), 1961-1965 (Front cover) TY Chen, J Chen, Y Tang, J Zhou, Y Guo, W-c Chang. 2020. Pathway from N‐Alkylglycine to Alkylisonitrile Catalyzed by Iron (II) and 2‐Oxoglutarate‐Dependent Oxygenases. Angewandte Chemie 132 (19), 7437-7441 J Li, H-j Liao, Y Tang, J-l Huang, L Cha, T-s Lin, J L Lee, IV Kurnikov, MG Kurnikova, W-c Chang, N-l Chan, Y Guo. 2020. Epoxidation catalyzed by the nonheme iron (II)-and 2-oxoglutarate-dependent oxygenase, AsqJ: Mechanistic elucidation of oxygen atom transfer by a ferryl intermediate. Journal of the American Chemical Society 142 (13), 6268-6284 (Front cover) L Cha, Y Tang, Y Guo, W-c Chang. 2020. Olefin, Nitrile and Isonitrile Installation Catalyzed by Metalloenzymes. Elsevier Y Guo, W-c Chang, J Li, M Davidson. 2020. Non-Heme Mono-Iron Enzymes: Co-Substrate-Dependent Dioxygen Activation. Elsevier LJ Rajakovich, M-E Pandelia, AJ Mitchell, W-c Chang, B Zhang, AK Boal, C Krebs, JM Bollinger Jr. 2019. A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases. Biochemistry 58 (12), 1627-1647 M Davidson, M McNamee, R Fan, Y Guo, W-c Chang. 2019. Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance. Journal of the American Chemical Society 141 (8), 3419-3423 J Zhang, PH Fan, GM Lin, W-c Chang, H Liu. 2019. Recent Progress in Unusual Carbohydrate-Containing Natural Products Biosynthesis. Elsevier CJ Thibodeaux, W-c Chang, H Liu. 2019. Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships. Methods in enzymology 620, 167-188