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个人简介

教育经历 2004.09-2007.06 西南大学,园艺学(花卉分子育种)专业,农学博士 2001.09-2004-07 西南大学(原西南农业大学),细胞生物学专业,理学硕士 1997.09-2001.06 西南大学荣昌校区(原四川畜牧兽医学院),动物科学专业,农学学士 工作经历 2024.06-至今:华南农业大学农学院/亚热带农业生物资源保护与利用国家重点实验室,研究员 2020.12-2024.05:华南农业大学生命科学学院/亚热带农业生物资源保护与利用国家重点实验室,研究员 2017.12-2018.11:美国康奈尔大学(Cornell University)/USDA-ARS, Robert W. Holley Center,Plant Science, 客座副教授(Visiting Associate Professor) 2011.07-2020.11:华南农业大学生命科学学院,历任助理研究员、副研究员和青年教授 2007.08-2011.06:华南农业大学生命科学学院,生物学博士后流动站,博士后

研究领域

1. 植物基因工程技术系统的研究 利用多种技术方法,进行DNA大片段、多基因的分子组装与转化系统的研究,以期能最终实现DNA分子的按需组装;开发元件化、标准化的植物合成生物学组装系统;开发基于CRISPR/Cas的多重基因组编辑与单碱基编辑系统、定点插入系统等,以期实现体内的定点修饰与编辑。 2. 植物代谢工程与合成生物学 利用开发的基因工程工具,在模式植物与作物中(水稻、番茄等),开展重要植物营养素、次生代谢产物(类黄酮、类胡萝卜素、甜菜红素以及重要经济价值的萜类药用化合物)的代谢调控与合成生物学应用研究。 3. 作物营养强化与功能营养型新种质创制 利用开发的多基因叠加系统与基因编辑系统等工具,在作物中(水稻等)对重要营养物质进行合成代谢工程操作,产生具有一种或多种重要植物营养元素或重要保健功能的生物活性物质,创制作物种质新资源。

近期论文

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Zhang R, Chai N, Liu T, Zheng Z, Lin Q, Xie X, Wen J, Yang Z, Liu Y-G*, Zhu Q*. The type V effectors for CRISPR/Cas-mediated genome engineering in plants. Biotechnology Advances, 2024, 74: 108382. (IF2022=16.0) Xue Z*, Zhao T, Zhu Q*, Qiao J*, Xuan YH*. New insights into the regulation, biosynthesis and mode of action of antimicrobial metabolites to control plant disease. Journal of Cellular Physiology, 2024, DOI: 10.1002/jcp.31154.(IF2022=5.6) Tan J*, Shen M, Chai N, Liu Q, Liu Y-G, Zhu Q*. Genome editing for plant synthetic metabolic engineering and developmental regulation. Journal of Plant Physiology, 2023, 291: 154141. (IF2022=4.3) Lin J, Yin X, Zeng Y, Hong X, Zhang S, Cui B, Zhu Q, Liang Z, Xue Z*, Yang D*. Progress and prospect: Biosynthesis of plant natural products based on plant chassis. Biotechnology Advances. 2023, 69: 108266. (IF2022=16.0) Luo W#, Tan J#, Li T, Feng Z, Ding Z, Xie X, Chen Y, Chen L, Liu Y-G, Zhu Q*, Guo J*. Overexpression of maize GOLDEN2 in rice and maize calli improves regeneration by activating chloroplast development. Science China Life Sciences, 2023, 66(2): 340-349. (IF2022=9.1) Zhu Q*, Tan J, Liu Y-G. Molecular farming using transgenic rice endosperm. Trends in Biotechnology, 2022, 40 (10): 1248–1260. (IF2022=17.3) Zhao Y#, Han J#, Tan J#, Yang Y, Li S, Gou Y, Luo Y, Li T, Xiao W, Xue Y, Hao Y, Xie X, Liu Y-G *, Zhu Q *. Efficient assembly of long DNA fragments and multiple genes with improved nickase-based cloning and Cre/loxP recombination. Plant Biotechnology Journal, 2022, 20 (10): 1983–1995. (IF2022=13.8) (封面文章) Xie X*, Li F, Tan X, Zeng D, Liu W, Zeng W, Zhu Q, Liu Y-G*. BEtarget: aversatile web-based tool to design guide RNAs for base editing in plants. Computational and Structural Biotechnology Journal, 2022, 20: 4009–4014. (IF2022=6.0) Zeng D#, Zheng Z#, Liu Y, Liu T, Li T, Liu J, Luo Q, Xue Y, Li S, Chai N, Yu S, Xie X, Liu Y-G, Zhu Q*. Exploring C-to-G and A-to-Y Base Editing in Rice by Using New Vector Tools. International Journal of Molecular Sciences, 2022, 23(14):7990. (IF2022=5.6) Ma K, Yang Z, Yang B, Liu Y-G, Zhu Q, Chen L*. Bioinformatic and functional analyses reveal the expansion base of the rice polyketide synthase III superfamily and the synergistic roles of OsPKS1 and OsPKS2 in male reproduction. Reproduction and Breeding, 2022, 2(1): 9–17. Han J#, Ma K#, Li H#, Su J#, Zhou L, Tang J, Zhang S, Hou Y, Chen L, Liu Y-G, Zhu Q*. All-in-one: A Robust Fluorescent Fusion Protein Vector Toolbox for Protein Localization and BiFC Analyses in Plants. Plant Biotechnology Journal, 2022,20 (6): 1098–1109. (IF2022=13.8) Tan J, Wang Y, Chen S, Lin Z, Zhao Y, Xue Y, Luo Y, Liu Y.-G, Zhu Q*. An Efficient Marker Gene Excision Strategy Based on CRISPR/Cas9- Mediated Homology-Directed Repair in Rice. International Journal of Molecular Sciences, 2022, 23(3): 1588. (IF2022=5.6) Tan J#, Zeng D#, Zhao Y#, Wang Y, Liu T, Li S, Xue Y, Luo Y, Xie X, Chen L, Liu Y-G, Zhu Q*. PhieABEs: a PAM-less/free high-efficiency adenine base editor toolbox with wide target scope in plants. Plant Biotechnology Journal, 2022, 20 (5): 934–943. (IF2022=13.8) (ESI高被引论文) Liu T#, ZengD#, Zheng Z, Lin Z, Xue Y, Li T, Xie X, Ma G, Liu Y-G*, Zhu Q*. The ScCas9++ variant expands the CRISPR toolbox for genome editing in plants. Journal of Integrative Plant Biology, 2021, 63(9):1611-1619. (IF2021=9.106) (# co-first author) Ma K, Han J, Zhang Z, Li H, Zhao Y, Zhu Q, Xie Y, Liu YG, Chen L*. OsEDM2L mediates m6 A of EAT1 transcript for proper alternative splicing and polyadenylation regulating rice tapetal degradation. Journal of Integrative Plant Biology, 2021, 63(11):1982-1994. (IF2021=9.106) Sun T#, *, Zhu Q#, Wei Z, Owens LA, Fish T, Kim H, Thannhauser TW, Cahoon EB, Li L*. Multi-strategy engineering greatly enhances provitamin A carotenoid accumulation and stability in Arabidopsis seeds. aBIOTECH, 2021, 2(3): 191-214. (# co-first author) Zhu Q*, Tan J, Wang B, Liu Y-G. Genetic Engineering for Increasing Antioxidant Content in Rice: Recent Progress and Future Perspective. 2021: 358-381; doi: 10.1002/9781119633174.ch19 (Chapter 19, in book:Molecular Breeding for Rice Abiotic Stress Tolerance and Nutritional Quality), WILEY Press Zhu Q, Liu Y-G*. TransGene Stacking II Vector System for Plant Metabolic Engineering and Synthetic Biology. Methods in molecular biology,2021, 2238:19-35; doi: 10.1007/978-1-0716-1068-8_2 (Chapter 2, in book: Rice Genome Engineering and Gene Editing), Humana Press Zeng D#, Liu T#, Tan J, Zhang Y, Zheng Z, Wang B, Zhou D, Xie X, Guo M, Liu Y-G*, Zhu Q*. PhieCBEs: Plant High-efficiency Cytidine Base Editors with Expanded Target Range. Molecular Plant, 2020, 13 (12): 1666–1669. (IF2020=13.164) (# co-first author) Liu, T#, Yu S#, Xu Z, Tan J, Wang B, Liu Y-G*, Zhu Q*. Prospects and Progress on Crocin Biosynthetic Pathway and Metabolic Engineering. Computational and Structural Biotechnology Journal, 2020, 18: 3278–3286. (IF2020=7.271) Zeng D, Liu T, Ma X, Wang B, Zheng Z, Zhang Y, Xie X, Yang B, Zhao Z, Zhu Q*, Liu Y-G*. Quantitative regulation of Waxy expression by CRISPR/Cas9-based promoter and 5'UTR-intron editing improves grain quality in rice. Plant Biotechnology Journal, 2020, 18 (12): 2385-2387. (IF2020=9.803). Tan J, Zhao Y, Wang B, Hao Y, Wang Y, Li Y, Luo W, Zong W, Li G, Chen S, Ma K, Xie X, Chen L, Liu Y‐G*, Zhu Q*. Efficient CRISPR/Cas9-based plant genomic fragment deletions by microhomology-mediated end joining. Plant Biotechnology Journal, 2020,18(11): 2161-2163. (IF2020=9.803) Wang B, Fang R, Chen F, Han J, Liu Y-G, Chen L*, Zhu Q*. A novel CCCH‐type zinc‐finger protein SAW1 activates OsGA20ox3 to regulate gibberellin homeostasis and anther development in rice, Journal of Integrative Plant Biology, 2020,62(10):1594-1606. (IF2020=7.061) Gong Q,Wang B, Lu X, Tan J, Hou Y, Liu T, Liu Y-G*, Zhu Q*. Nicking Endonuclease-Mediated Vector Construction Strategies for Plant Gene Functional Research. Plants, 2020, 9 (9): 1090. (IF2020=3.935). Hao Y, Zong W, Zeng D, Han J, Chen S, Tang J, Zhao Z, Li X, Ma K, Xie X, Zhu Q, Chen Y, Zhao X, Guo J*, Liu Y-G*. Shortened snRNA promoters for efficient CRISPR/Cas-based multiplex genome editing in monocot plants. Science China Life Sciences, 2020, 63 (6):933-935. (IF2020=6.038). Zeng D, Li X, Huang J, Li Y, Cai S, Yu W, Li Y, Huang Y, Xie X, Gong Q, Tan J, Zheng Z, Guo M, Liu Y-G*, Zhu Q*. Engineered Cas9 variant tools expand targeting scope of genome and base editing in rice. Plant Biotechnology Journal. 2020, 18(6):1348-1350. (IF2020=9.803) Zhu Q, Wang B, Tan J, Liu T, Li L, Liu Y-G*. Plant Synthetic Metabolic Engineering for Enhancing Crop Nutritional Quality. Plant Communications. 2020, 1, 100017.(IF2021=8.625)

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