个人简介
广东省农业科技特派员,广州市农业科技特派员,国家海水鱼产业体系病毒病防控岗位科学家成员。主持国家自然科学基金、广东省自然科学基金、中国博士后基金、华南农业大学创新创业基金等项目7项,参加国家与省部级项目10项,发表论文20篇,参编专著1部,申请国家发明专利11项,6项获得授权。
工作简历:
2008.09-2011.03 清华大学化学工程系,博士后
2011.03-2017.09 中国科学院南海海洋研究所 助理研究员
2017.09-至今 华南农业大学海洋学院,副研究员
教育经历
2004.09-2008.07 中山大学海洋生物学专业, 理学博士学位
2000.09-2004.07 湖南师范大学生物科学专业, 理学学士学位
承担科研项目情况:
主持项目:
1.国家自然科学基金青年基金:石斑鱼虹彩病毒SGIV囊膜蛋白VP088在病毒感染过程中的作用机制研究(31502207),2016.01-2018.12
2.广东省自然科学基金面上项目:石斑鱼虹彩病毒SGIV囊膜蛋白VP019功能研究.(2017A030313180) 2017.06-2020.05
3.广东省自然科学基金面上项目:海洋克雷伯氏菌dha操纵子基因表达与调控的分子机制(2015A030313854),2015.08-2018.08
4.广东省精准扶贫科技特派员项目,石斑鱼健康养殖技术示范推广(2018A0118),2018.06-2020.06
5.广州市农业科技特派员项目,加州鲈鱼健康养殖技术示范推广2019.06-2021.06
6.华南农业大学创新创业项目,海水鱼类肠道益生菌抗病功能发酵饲料,2019.07-2021.07
7.中国博士后基金:利用Red重组系统敲除肺炎克雷伯氏菌乳酸脱氢酶与2,3-丁二醇脱氢酶基因(20100470365),2010.01-2011.06
参加项目:
8.国家自然科学基金面上项目:石斑鱼虹彩病毒SGIV VP131逃逸宿主天然免疫的分子机制研究(31972837),2020.01-2023.12
9.海水鱼体系病毒病防控岗位科学家项目 2018.05-2020.05
10.2018年省级促进经济发展专项资金(海洋经济发展用途)项目 2012.01-2015.12
11.国家海洋公益性行业科研专项项目:海洋微生物发酵法生产1,3-丙二醇的中试工艺与产品示范(201205020-4), 2012.01-2015.12
12.广东省海洋经济创新发展区域示范专项课题:海洋微生物特异功能酶与生物化工技术实验室建设 (GD2012-D01-002) 2013.06-2016.06
13.国家自然科学基金重点项目:在单病毒粒子水平研究石斑鱼虹彩病毒SGIV侵染宿主细胞的机制(31330082),2014-2018
14.国家自然科学基金面上项目:溶酶体途径在石斑鱼虹彩病毒SGIV诱导类凋亡中的作用机制研究(31472309),2015.01-2018.12
15.国家自然科学基金面上项目:石斑鱼PIAS1调控病毒诱导的I型干扰素表达的分子机制(31572643 ),2016.01-2019.12
16.广东省海洋渔业科技与产业发展专项:石斑鱼虹彩病毒疫苗研发与规模化制备关键技术(A201501C01),2015.06-2018.05
17.广东省科技计划项目:水生经济动物病毒防控技术研究(2011A020102002),2013.01-2015.12,
18.石斑鱼免疫抗病功能基因制品的研发(2014J4100213)
专利申请与授权情况:
1.秦启伟、周胜、黄晓红、黄友华、魏京广。一种枯草芽孢杆菌7K及其应用 专利号 201711166108.8
2.秦启伟、黄晓红、魏京广、周胜、黄友华。一种石斑鱼虹彩病毒的亚单位疫苗及其制备方法和应用 专利号 201711377044.6
3.秦启伟、周胜、黄晓红、黄友华、魏京广。一种石斑鱼虹彩病毒的重组囊膜蛋白疫苗及其应用 专利号201810008344.5
4.周胜,秦启伟,魏京广,李莉莉,付静。一株生产1,3-丙二醇的工程菌及其构建方法,授权号:ZL201310071754.1
5.周胜,秦启伟,魏京广,李莉莉,付静。一种红树林克雷伯氏菌及其在发酵法生产1,3-丙二醇中的应用,授权号:ZL201210053231.X.
6.周胜,秦启伟,李莉莉,黄友华,高任。一株失活乙酰乳酸合成酶的工程菌及其在生产1,3-丙二醇中的应用,公开号:CN103305543A
7.周胜,,秦启伟,黄友华,俞也频,尼松伟。一株敲除丙酮酸甲酸裂解酶基因的工程菌及其应用,授权号:ZL2014108346756.6
8.周胜,秦启伟, 王著希,黄友华。一株双基因敲除工程菌构建方法及其在发酵生产1,3-丙二醇中的应用。申请号:201610179046.3 公开号CN105936915A
9.刘德华,周胜,罗吉安。一种发酵生产1,3-丙二醇的方法,授权号:ZL201110199548.X.
10.刘德华,周胜,罗吉安。构建转苹果酸酶基因工程菌促进发酵产1,3-丙二醇的方法,授权号:ZL201110069870.0
11.魏京广,秦启伟,周胜,许濛。石斑鱼翻译控制肿瘤蛋白TCTP 及其编码基因在抗鱼类神经坏死病毒方面的应用。公开号:CN104497120A
Books
Hongjuan Liu*, Xianjin OU, Sheng Zhou, Dehua Liu*. Microbial 1,3-Propanediol, Its Copolymerization with Terephthalate, and Applications. P405-426. In: Guo-qiang Chen. Plastics from Bacteria-Natural Functions and Applications. Springer, 2010, 0- 462
近期论文
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1. Sheng Zhou, Deli Song, Xiaofeng Zhou, Xinliang Mao, Xuefeng Zhou, Sunli Wang, Jingguang Wei, Youhua Huang, Wenxiong Wang, Su-Mei Xiao*, Qiwei Qin*. Characterization of Bacillus subtilis from gastrointestinal tract of hybrid Hulong grouper (Epinephelus fuscoguttatus × E. lanceolatus) and its effects as probiotic additives. Fish and Shellfish Immunology ( IF 3.185 ) 84 (2019) 1115–1124
2. Sheng Zhou*,Youhua Huang, Xinliang Mao, Lili Li, Chuanyu Guo, Yongli Gao and Qiwei Qin* Impact of acetolactate synthase inactivation on 1,3-propanediol fermentation by Klebsiella pneumoniae. Plos ONE. ( IF 2.766 ) 2019 Apr 24;14(4):e0200978.
3. Jingguang Wei, Chen Li, Xin Zhang, Sheng Zhou, Shaoqing Zang, Shina Wei, Qiwei Qin Molecular cloning and characterization of Aos1 and Uba2 from the orange-spotted grouper (Epinephelus coioides) . Fish & Shellfish Immunology ( IF 3.185 )2018;81:343-353.
4. 王著希,周 胜*,黄友华,王劭雯,黄晓红,周永灿,秦启伟*。细胞骨架蛋白Actin参与石斑鱼虹彩病毒SGIV释放。水产学报, 2017年第41卷第8期,1319-1327(*通讯作者) WANG Zhuxi, ZHOU Sheng*, HUANG Youhua, WANG Shaowen, HUANG Xiaohong, ZHOU Yongcan, QIN Qiwei*. Actin filament involved in the release of SGIV from host cells. Journal of Fisheries of China2017, Vol. 41, No. 8, 1319-1327
5. Ying Yang, Youhua Huang, Yepin Yu, Min Yang, Sheng Zhou, Qiwei Qin *, Xiaohong Huang. RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper. Fish & Shellfish Immunology 55 (2016) 304-314
6. Zhou Sheng, Li Lili, Perseke Marleen, Huang Youhua, Wei Jingguang and Qin Qiwei*. Isolation and characterization of a Klebsiella pneumoniae strain from mangrove sediment for efficient biosynthesis of 1,3-propanediol. Science Bulletin. 2015, 60 (5), 511-521
7. Youhua Huang, Zhengliang Ouyang, Wei Wang, Yepin Yu, Pengfei Li, Sheng Zhou, Shina Wei, Jingguang Wei, Xiaohong Huang, Qiwei Qin*. Antiviral role of grouper STING against iridovirus infection. Fish Shellfish Immunol. 2015, 7; 47(1):157-167.
8. Honglian Zhang, Sheng Zhou, Liqun Xia, Xiaohong Huang,Youhua Huang, Jianhao Cao, Qiwei Qin*. Characterization of the VP39 Envelope Protein from Singapore grouper iridovirus. Cannada journal of microbiology. 2015, 29:1-14.
9. 李莉莉,周胜*,高品,郭传宇,余也频,尼松伟,李鹏飞,秦启伟*. 磷酸根对海洋克雷伯氏菌合成1,3-丙二醇代谢的影响。热带海洋学报2015 年 第34 卷 第5 期: 27-35 (*通讯作者) Li LL, Zhou S*, Gao P, Guo CY, Yu YP, Ni SW, Li PF, Qin QW*. Effect of phosphate on 1,3-propanediol metabolism by marine Klebsiella pneumoniaHSL4.Journal of Tropical Oceanology, 2015, 34 ,5: 27-35 (*通讯作者)
10. LI Lili, ZHOU Sheng*, JI Huasong, GAO Ren, QIN Qiwei*. Optimization of fermentation conditions for 1,3-proanediol production by marine Klebsiella pneumonia HSL4 using Response Surface methodology. Chinese Journal of Oceanology and Limnology 2014, 32(5):1036-1045(*通讯作者)
11. Ji, H., Wei, J., Wei, S., Yan, Y., Huang, Y., Huang, X., Zhou, S., Zhou, Y., Qin, Q*. Molecular cloning and expression of a C-type lectin-like protein from orange-spotted grouper Epinephelus coioides. Journal of Fish Biology. 2014, 84, (2), pp. 436 – 447
12. Sheng Zhou, Li-li Li, Jing-guang Wei, Qi-wei Qin*. Genome sequence of Klebsiella pneumoniae HSL4, a new strain isolated from mangrove sediment for biosynthesis of 1,3-propanediol. Genome Announcement. 2013; 1(3): e00177-13.
13. Ou-yang ZL, Wang PR, Huang YH, Huang XH, Wan QJ, Zhou S, Wei JG, Zhou YC, Qin QW*. Selection and identification of Singapore grouper iridovirus vaccine candidate antigens using bioinformatics and DNA vaccination. Veterinary Immunology and Immunopathology. 2012 149:38-45.
14. Zhou Sheng#, Wan Qing Jiao#, Cao Jian Hao, Huang You Hua, Huang Xiao Hong, Ye Li Li, Deng Qing Li, Qin Song Lin, Qin Qi Wei*. Proteomic analysis of Singapore grouper iridovirus envelope proteins and characterization of a novel envelope protein VP088. Proteomics 2011;11(11):2236-48 (#并列第一作者)
15. Qing-Jiao Wan, Jie Gong, Xiao-Hong Huang, You-Hua Huang, Sheng Zhou, Jian-Hao Cao, Li-Li Ye, Qi-Wei Qin*. Identification and characterization of a novel capsid protein encoded by Singapore grouper iridovirus ORF038L. Arch Virol 2010;155:351–359
16. An-an Hong, Ke-ke Cheng, Feng Peng, Sheng Zhou, Yan Sun, Can-Ming Liu and De-Hua Liu*. Strain isolation and optimization of process parameters for bioconversion of glycerol to lactic acid. J Chem Technol Biotechnol 2009;84:1576-1581
17. Mao Xinliang#, Zhou Sheng#, Xu Dan, Gong Jie, Cui Huachun, Qin Qiwei*. Rapid and Sensitive Detection of Singapore grouper iridovirus by Loop-Mediated Isothermal Amplification (LAMP). Journal of Applied Microbiology. 2008, 105, 389-97. (#并列第一作者)
18. Zhou Sheng, Hou Zhiwei, Li Ning, Qin Qiwei*. Development of a SYBR Green I Real-Time PCR for Quantitative Detection of Vibrio alginolyticus in Seawater and Seafood. Journal of Applied Microbiology. 2007, 103, 1897–1906
19. Zhou Sheng, Chen Liangbi*. Study on Elongated Uppermost Internode Cell of TGMS Rice with Eui Gene. Life Science Research,2006,10(3)S1:114-118 (In Chinese) 周胜,陈良碧.长穗颈不育水稻穗颈节间的细胞学研究.生命科学研究2006,10(3)S1:114-118