个人简介

B.A., Bowdoin College (1986) Ph.D., Harvard University (1992) DOE Distinguished Postdoctoral Fellow, Lawrence Berkeley Laboratory (1993-1995)

研究领域

Analytical Chemistry/Physical Chemistry

Applications of nanoscience and nanotechnology in environmental catalysis, remediation, CWA decontamination, drug delivery; EPR and solid state NMR; synthesis and characterization of nanocrystalline zeolites and zeolite structures. Research Interests: In the Larsen group, we are interested in the synthesis, characterization and environmental and health applications and implications of porous nanomaterials, such as zeolites and mesoporous silica. Zeolites are crystalline, microporous materials which have large surface areas and are widely used in applications such as separations, ion exchange and catalysis. Zeolites can be synthesized with a wide range of pore sizes and topologies. The zeolite chemical composition, framework topology and pore size can be varied to control selectivity and reactivity. Similarly, mesoporous silica materials have high surface areas, tunable pore sizes with narrow distributions, well-defined surface properties, and low toxicity which are advantageous for environmental and biomedical applications. The main differences between zeolites and mesoporous silica are the pore sizes which are typically less than 1 nm in diameter for microporous zeolites and greater than 1 nm in diameter for mesoporous silica and the crystallinity in that the walls of mesoporous silica materials are amorphous while zeolites are crystalline. Our approach is to systematically and strategically vary the properties of the zeolites and mesoporous silica such as particle size and surface functionalization in order to optimize their performance in various applications. Synthesis and Characterization of Zeolite and Mesoporous Silica Nanomaterials We are interested in the synthesis of new zeolite and mesoporous silica materials with improved properties, such as those shown in the electron microscope images below. By controlling particle size and porosity, the properties of the zeolite or mesoporous silica host can be varied to increase diffusion, mass transfer and potentially, reactive surface area. The zeolite and mesoporous silica nanomaterials characterization of zeolite and mesoporous silica nanomaterials using magnetic resonance methods (solid state and liquid NMR and EPR) as well as other physicochemical techniques. Solution state NMR methods can be exploited to study the structure and dynamics of the surface functionalized zeolite and mesoporous silica nanoparticles. Environmental and Health Applications and Implications Environmental and health applications for zeolite and mesoporous silica nanoparticles are being explored. For example, magnetic mesoporous silica nanoparticles are being explored as adsorbents for heavy metals from water followed by the magnetic recovery of the contaminated particles. Mesoporous silica and zeolites generally exhibit low toxicity and good biocompatibility and are being investigated for use in drug delivery and imaging. The loading and release of small drug molecules, such as aspirin, doxorubicin, and fluorouracil, are being examined as a function of zeolite/mesoporous silica pore size and surface functionality. Density functional theory (DFT) methods are being used to model to better understand the loading and release properties. In addition, the environmental and health implications of porous nanomaterials are being investigated specifically with in vitro studies of the cytotoxicity of zeolite and mesoporous silica nanomaterials as a function of size and surface modification. These results are closely correlated with careful characterization of nanomaterial properties.

近期论文

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Sean E. Lehman, Yulia Tataurova, Paul S. Mueller, S. V. Santhana Mariappan, and Sarah C. Larsen. Ligand Characterization of Covalently-Functionalized Mesoporous Silica Nanoparticles: An NMR Toolbox Approach. Journal of Physical Chemistry C. 2014 118, 29943-29951. Sean E. Lehman and Sarah C. Larsen. Zeolite and Mesoporous Silica Nanomaterials: Greener Syntheses, Environmental Applications and Biological Toxicity. Environmental Science: Nano 2014, 1, 200-213. Sarah C. Larsen. Nanocrystalline and Hierarchical Zeolites, Chapter in Dekker Encyclopedia of Nanoscience and Nanotechnology, Third Edition. CRC Press: New York. 2014, pp. 5103-5113. Paul S. Mueller and Sarah C. Larsen. Incorporation of Germanium into the Framework of Nanocrystalline Faujasite. Microporous and Mesoporous Materials 2013, 180, 229-234. Ashish Datt, Nicholas Ndiege, and Sarah C. Larsen. Development of Porous Nanomaterials for Applications in Drug Delivery and Imaging. Nanomaterials for Biomedicine, American Chemical Society, 2013. Ashish Datt, Eric Burns, Nikhil Dhuna, and Sarah C. Larsen. Loading and Release of 5-Fluorouracil from HY Zeolites with Varying SiO2/Al2O3 Ratios. Microporous and Mesoporous Materials 2013, 167, 182–187 Ashish Datt, Daryl Fields, and Sarah C Larsen. An Experimental and Computational Study of the Loading and Release of Aspirin from Zeolite HY. Journal of Physical Chemistry C 2012, 116, 21382–21390. Ashish Datt, Izz El-Maazawi, and Sarah C. Larsen. Aspirin Loading and Release from MCM-41 Functionalized with Aminopropyl Groups via Co-condensation or Postsynthesis Modification Methods. Journal of Physical Chemistry C 2012, 116, 18358-18366. Kevin D. Dubois, Anton Petushkov, Elizabeth Garcia Cardona, Sarah C. Larsen, and Gonghu Li. Adsorption and Photochemical Properties of a Molecular CO2 Reduction Catalyst in Hierarchical Mesoporous ZSM-5: An In Situ FTIR Study. Journal of Physical Chemistry Letters 2012, 3, 486-492. Yulia Tataurova, Michael J. Sealy, Russell G. Larsen, and Sarah C. Larsen. Surface-Selective Solution NMR Studies of Functionalized Zeolite Nanoparticles. Journal of Physical Chemistry Letters 2012, 3, 425-429. Nicholas Ndiege, Renugan Raidoo, Michael K. Schultz, and Sarah C. Larsen. Preparation of a Versatile Bifunctional Zeolite for Targeted Imaging Applications. Langmuir 2011, 27, 2904-2909. Anton Petushkov, Jasmine Freeman, and Sarah C. Larsen. Framework Stability of Nanocrystalline NaY in Aqueous Solution at Varying pH. Langmuir 2010, 26, 6695-6701. Sarah C. Larsen, Norbert J. Pienta, and Russell G. Larsen. Development of Hands-on Nanotechnology Content Materials: Undergraduate Chemistry and Beyond. Nanotechnology in Undergraduate Education. January 11, 2010, 87-99. William M. Ames and Sarah C. Larsen. DFT Calculations of EPR Parameters for Copper(II)-Exchanged Zeolites Using Cluster Models. Journal of Physical Chemistry A 2010, 114, 589-594 Anton Petushkov, Janjira Intra, Jessica B. Graham, Sarah C. Larsen, and Aliasger K. Salem. Effect of Crystal Size and Surface Functionalization on the Cytotoxicity of Silicalite-1 Nanoparticles. Chemical Research in Toxicology 2009, 22, 1359-1368. William M. Ames and Sarah C. Larsen. Density Functional Theory Investigation of EPR Parameters for Tetragonal Cu(II) Model Complexes with Oxygen Ligands. Journal of Physical Chemistry A 2009, 113, 4305-4312. Sarah C. Larsen and Dennis Chasteen. Hyperfine and Quadropolar Interactions in Vanadyl Protein and Model Complexes: Theory and Experiment in Biological Magnetic Resonance, Vol 29. Metals in Biology: Applications of High Resolution EPR to Metalloenzymes, Eds. Graeme R. Hanson and Lawrence J. Berliner, Springer Publishers. 2009. Vicki H. Grassian, Jennifer D. Schuttlefield, and Sarah C. Larsen. ATR–FTIR Spectroscopy in the Undergraduate Chemistry Laboratory. Part II: A Physical Chemistry Laboratory Experiment on Surface Adsorption. Journal of Chemical Education 2008, 85, 282. Karna Barnquist and Sarah C. Larsen. Chromate Adsorption on Amine-Functionalized Nanocrystalline Silicalite-1. Microporous and Mesoporous Materials 2008, 116, 365-369. Ramasubramanian Kanthasamy, Karna Barquist, and Sarah C. Larsen. Transition Metal and Organic Functionalization of Hollow Zeolite Structures. Microporous and Mesoporous Materials 2008, 113, 554-561.