个人简介

B.S., University of Florida (1978) Ph.D., University of Illinois (1983) Postdoctoral Research Associate, Cornell University (1983-84) Alfred P. Sloan Foundation Fellow (1990-92); NIH Research Career Development Award, (1990-95)

研究领域

Organic Chemistry

Our research program is dedicated to the discovery, isolation, and structure determination of novel biologically active natural products from fungi. Many antibiotics, anticancer agents, and other important pharmaceuticals and agrochemicals in use today have been discovered through studies of the chemistry of bacteria and fungi. Our studies utilize observations in fungal ecology in order to target certain classes of fungi as logical sources of valuable new metabolites. Through these studies, we also seek to contribute to a better understanding of the roles of these compounds in the life cycles of the organisms that produce them. Current efforts in this area include studies of fungal metabolites involved in interspecies competition within natural ecosystems, and investigations of fungi that attack, colonize, and damage others as potential sources of antifungal agents. This research is interdisciplinary, and most of our projects involve collaboration with mycologists and colleagues from other neighboring disciplines. The process of discovering and isolating biologically active natural products is guided by assays that have pharmaceutical or agricultural relevance, including antifungal, antibacterial, antiinsectan, and anticancer screens. Some of these bioassays are carried out by our research group, while others are conducted by collaborating scientists. We employ a variety of chromatographic techniques, especially HPLC, in the analysis, isolation, and purification of compounds of interest. State-of-the-art methods for structure determination, such as high resolution mass spectrometry, high-field 1H and 13C NMR spectroscopy, and 2D-NMR techniques are then applied to the solution of structural and stereochemical problems. Some representative new bioactive natural products discovered by our research group are shown in the accompanying figure. These metabolites exemplify the prolific biosynthetic capabilities of fungi, and include compounds with new ring systems and representatives of other rare structural classes.

近期论文

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Bioactive Natural Products from Fungicolous Hawaiian Isolates: Secondary Metabolites from a Phialemoniopsis sp. Kaur, A.; Rogers, K. D.; Swenson, D. E.; Dowd, P.F.; Wicklow, D.T.; Gloer, J. B. Mycology 2014, 5, 120-129. First Total Syntheses and Antimicrobial Evaluation of Penicimonoterpene, a Marine-derived Monoterpenoid and Its Various Derivatives. Zhao, J.-C.; Li, X.-M.; Gloer, J. B.; Wang, B-G. Marine Drugs, 2014, 12, 3352-3370. Pyrano-isoflavans from Glycyrrhiza uralensis with Antibacterial Activity against Streptococcus mutans and Porphyromonas gingivalis. Villinski, J.; Bergeron, C.; Cannistra, J.; Gloer, J. B.; Coleman, C.; Ferreira, D.; Azelmat, J.; Grenier, D.; Gafner, S. J. Nat. Prod. 2014, 77, 521-526. Diplodiatoxin, Chaetoglobosins, and Diplonine Associated with a Field Outbreak of Stenocarpella Ear Rot in Illinois. Rogers, K. D.; Cannistra, J. C.; Gloer, J. B.; Wicklow, D.T., Mycotoxin Research 2014, 30, 61-70. Coprophilous fungi: Antibiotic discovery and functions in an underexplored arena of microbial defensive mutualism. Bills, G. F.; Gloer, J. B.; An, Z. Curr. Opin. Microbiol., 2013, 16, 549–565. Product-to-Parent Reversion of Trenbolone: Unrecognized Risks for Endocrine Disruption. Qu, S.; Kolodziej, E. P.; Long, S. A.; Gloer, J. B.; Patterson, E. V.; Baltrusaitis, J.; Jones, G. D.; Benchetler, P. V.; Cole, E. A.; Kimbrough, K. C.; Tarnoff, M.; Cwiertny, D. M., Science 2013, 342, 347-351. Identification and Environmental Implications of Photo-Transformation Products of Trenbolone Acetate Metabolites. Kolodziej, E.P.; Qu S.; Forsgren, K.; Long, S.A.; Gloer, J.B.; Jones, G.; Schlenk, D.; Baltrusaitis, J.; Cwiertny, D.M., Environ. Sci. Technol. 2013, 47, 5031−5041. Halogenated Organic Molecules of Rhodomelaceae Origin: Chemistry and Biology. Wang, B.-G.; Gloer, J.B.; Ji, N.-Y; Zhao, J-C. Chem. Rev. 2013, 113, 3632−3685. New Nitrogen-containing Bromophenols from the Marine Red Alga Rhodomela confervoides and their Radical-Scavenging Activity. Li, K.; Li, X.-M.; Gloer, J.B.; Wang, B.-G. Food Chem. 2012, 135, 868-872. Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A. Cardellina, J.H., II; Roxas-Duncan, V.I.; Montgomery, V.; Eccard, V.; Campbell,Y.; Hu, X.; Khavrutskii, I.; Tawa, G.J.; Wallqvist, A.; Gloer, J.B.; Phatak, N.L.; Höller, U.; Soman, A.G.; Joshi, B.K.;Hein, S.M.; Wicklow, D.T.; Smith, L.A. ACS Med. Chem. Lett. 2012, 3, 387−391. Aflaquinolones A–G: Secondary Metabolites from Marine and Fungicolous Isolates of Aspergillus Spp. Neff, S.A; Lee, S. U.; Asami, Y; Ahn, J. S.; Oh, H.; Baltrusaitis, J.; Gloer, J. B.; Wicklow, D. T. J. Nat. Prod. 2012, 75, 464-472. Isolation, Characterization, and Antioxidant Activity of Bromophenols of the Marine Red Alga Rhodomela confervoides. Li, K.; Li, X.-M.; Gloer, J.B.; Wang, B.-G. J. Agric. Food Chem. 2011, 59, 9916-9921. Biological Activity of Peanut (Arachis hypogaea) Phytoalexins and Selected Natural and Synthetic Stilbenoids. Sobolev, V. S; Khan, S.I.; Tabanca; N., Wedge, D.E.; Manly, S.P.; Cutler, S.J.; Coy, M.R.; Becnel, J.J.; Neff, S.A; Gloer, J.B. J. Agric. Food Chem. 2011, 59, 1673-1682. Phomalevones A-C: Dimeric and Pseudodimeric Polyketides from a Fungicolous Hawaiian Isolate of Phoma sp. (Cucurbitariaceae). Shim, S. H.; Baltrusaitis, J.; Gloer, J. B.; Wicklow, D.T. J. Nat. Prod. 2011, 72, 395-401. Bioactive Metabolites from Stenocarpella maydis, a Stalk and Ear Rot Pathogen of Maize. Wicklow, D.T.; Rogers, K.D.; Dowd, P.F.; Gloer, J.B. Fungal Biology 2011, 115, 133-142. New Pterocarpenes Elicited by Aspergillus caelatus in Peanut (Arachis hypogaea) Seeds. Sobolev, V. S; Neff, S.A; Gloer, J.B.; Khan, S.I.; Tabanca, N., De Lucca, A.J.; Wedge, D.E. Phytochemistry 2010, 71, 2099-2107. New Nonadride Analogues from a Freshwater Isolate of an Undescribed Fungus Belonging to the Order Pleosporales. Hosoe, T., Gloer, J. B.; Wicklow, D.T.; Raja, H..; Shearer, C. A. Heterocycles 2010, 81, 2123-2130. New Dimeric Stilbenoids from Fungal-Challenged Peanut (Arachis hypogaea) Seeds. Sobolev, V. S; Neff, S.A; Gloer, J.B. J. Agric. Food Chem. 2010, 58, 875-881. Hymenopsins A and B and a Macrophorin Analogue from a Fungicolous Hymenopsis Sp. Schmidt, L.E.; Deyrup, S.T.; Baltrusaitis, J.; Swenson, D.C.; Wicklow, D.T.; Gloer, J.B. J. Nat. Prod. 2010, 73, 404-408. Radicinol Analogs from the Freshwater Aquatic Fungus Xylomyces chlamydosporus. Hosoe, T., Gloer, J. B.; Raja, H..; Shearer, C. A. Mycotoxins 2010, 60, 1-6.