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个人简介

招生专业 081203-计算机应用技术 招生方向 生物信息学,人工智能, 健康医学大数据挖掘 教育背景 2013-09--2016-07 清华大学 博士 1997-09--2000-07 北京大学 硕士学位 1990-09--1995-07 北京中医药大学 学士学位 科研项目 ( 1 ) 非编码RNA调控网络及功能研究, 主持, 部委级, 2011-10--2013-10 ( 2 ) 蛋白质组海量质谱数据的解析及其在人类基因组注释中的应用, 主持, 国家级, 2010-01--2014-12 ( 3 ) 病毒性肝炎恶性转化的多元调控网络研究, 主持, 国家级, 2013-01--2015-12 ( 4 ) 非编码RNA参与的生物网络分析, 主持, 国家级, 2011-01--2013-12 ( 5 ) siRNA药物设计软件研发, 主持, 国家级, 2012-11--2015-12 ( 6 ) 基于高通量测序数据的长非编码RNA调控网络及在癌症中的应用, 主持, 国家级, 2014-01--2017-12 ( 7 ) 基础医学科学数据中心共建项目, 主持, 国家级, 2016-06--2017-06 ( 8 ) 肝癌极高危人群队列的建立及早期诊断与预警研究, 参与, 国家级, 2015-04--2016-12 ( 9 ) 基于不同测序策略的长非编码RNA拼接、鉴定算法和功能注释的系统性研究, 主持, 国家级, 2018-01--2020-12 ( 10 ) 后基因组时代的高通量生命多组学_x005f_x000b_数据分析算法研究, 主持, 市地级, 2018-01--2019-12 ( 11 ) 特色经济林重要性状形成与调控-NGS数据分析算法研究, 主持, 国家级, 2019-01--2021-12

研究领域

健康医疗大数据挖掘 生物信息学

近期论文

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(1) NPInter v4.0: an integrated database of ncRNA interactions., Nucleic Acids Res., 2020, 通讯作者 (2) Macrophages-induced long noncoding RNA H19 up-regulation triggers and activates the miR-193b/MAPK1 axis and promotes cell aggressiveness in hepatocellular carcinoma., Cancer Lett, 2020, 通讯作者 (3) SymMap: an integrative database of traditional Chinese medicine enhanced by symptom mapping, Nucleic Acids Res, 2019, 通讯作者 (4) 6mA-DNA-binding factor Jumu controls maternal-to-zygotic transition upstream of Zelda., Nat Commun, 2019, 第 8 作者 (5) Application of a deep convolutional neural network in the diagnosis of neonatal ocular fundus hemorrhage, Biosci Rep, 2018, 通讯作者 (6) FSPP: A Tool for Genome-Wide Prediction of smORF-Encoded Peptides and Their Functions, Frontiers in genetics, 2018, 通讯作者 (7) Comprehensive Characterization of the RNA Editomes in Cancer Development and Progression, Frontiers in genetics, 2018, 通讯作者 (8) Protein-coding genes combined with long noncoding RNA as a novel transcriptome molecular staging model to predict the survival of patients with esophageal squamous cell carcinoma., Cancer Commun, 2018, 通讯作者 (9) From Big Data to Knowledge in Precision Medicine, Science(special issue), 2018, 通讯作者 (10) NONCODEV5: a comprehensive annotation database for long non-coding RNAs., Nucleic Acids Res., 2018, 通讯作者 (11) Several microRNAs could predict survival in patients with hepatitis B-related liver cancer, Scientific Reports, 2017, 第 3 作者 (12) Identification and function annotation of long intervening noncoding RNAs, BRIEFINGS IN BIOINFORMATICS, 2017, 通讯作者 (13) dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers, Nucleic Acids Research, 2017, 第 4 作者 (14) NONCODE 2016: an informative and valuable data source of long noncoding RNAs, Nucleic Acids Research, 2016, 第 1 作者 (15) Identification and function annotation of long intervening noncoding RNAs, Briefings in Bioinformatics, 2016, 通讯作者 (16) Long non-coding RNA expression profiles of Hepatitis C virus-related dysplasia and hepatocellular carcinoma, Oncotarget, 2015, 第 1 作者 (17) Dr.VIS v2.0: an updated database of human disease-related viral integration sites in the era of high-throughput deep sequencing, Nucleic Acids Research, 2015, 通讯作者 (18) Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis, Journal of Hepatology, 2014, 通讯作者 (19) De novo approach to classify protein-coding and non-coding transcripts by utilizing sequence intrinsic composition, Methods In Molecular Biology, 2014, 通讯作者 (20) Computational Methods To Predict Long Non-Coding RNA Functions Based On Co-Expression Network, Methods In Molecular Biology, 2014, 第 1 作者 (21) NONCODEv4: exploring the world of long non-coding RNA genes, Nucleic Acids Research , 2014, 通讯作者 (22) Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts, Nucleic Acids Research, 2013, 通讯作者 (23) Long non-coding RNAs function annotation: a global prediction method based on bi-colored networks , Nucleic Acids Research, 2013, 通讯作者 (24) NONCODE v3.0: Integrative annotation of long noncoding RNAs , Nucleic Acids Research , 2012, 通讯作者 (25) Large-scale prediction of long noncoding RNA functions in a coding-noncoding gene co-expression network, Nucleic Acids Research , 2011, 通讯作者 (26) ncFANs: a web server for functional annotation of long non-coding RNAs, Nucleic Acids Research , 2011, 通讯作者

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