个人简介

University of Texas, Austin - B.A. in Chemistry (Highest Honors) University of California, Berkeley - Ph.D. in Organic Chem. (C.H. Heathcock) Columbia University - NSF Postdoc. Fellow in Organic Chem. (G. Stork) Awards Phi Beta Kappa, December 1975. Fannie and John Hertz Foundation Fellow, 1978-80. Dreyfus Foundation Award for Newly-Appointed Faculty, 1982-87. Eli Lilly Grantee, 1984-86. NSF Presidential Young Investigator, 1985-90. Alfred P. Sloan Research Fellow, 1986-88. AAAS-Newcomb Cleveland Prize, 1991 (best paper in Science). Intellectual Property Owners Distinguished Inventor Award, 1993. John Simon Guggenheim Memorial Foundation Fellow, 1994-95. Outstanding Young Texas Ex Award, University of Texas Ex-Student's Association, 1995. Fellow of the AAAS, 1996. Chemical Pioneer Award, American Institute of Chemists, 2004.

研究领域

Organic Chemistry/Chemical Biology

Dr. Pirrung is an organic chemist with research in the areas of chemical biology, synthesis, and nucleic acids. He is a pioneer in the field of microarrays, which have important biological applications in genomics. Recent interests have included combinatorial chemistry, focused on solid-phase synthesis and natural products.

近期论文

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immy Thomas, Natasha Sharma, Reyna Gonzalez, Peng-Wen Pao, Florence M. Hofman, Thomas C. Chen, Stan G. Louie, Michael C. Pirrung, and Axel H. Schönthal, "Repositioning of Verrucosidin, a Purported Inhibitor of Chaperone Protein GRP78, as an Inhibitor of Mitochondrial Electron Transport Chain Complex I," PLOS One, 8, e65695 (2013). Link Michael C. Pirrung and Jenifer N. Nalbandian, "Catalyzed Claisen Rearrangements of O-Allyl Kojates," Tetrahedron Lett., 54, 3752 (2013). Link John Opoku-Ansah, Tannya R. Ibarra-Rivera, Michael C. Pirrung, and André S. Bachmann, "Syringolin B-inspired Proteasome Inhibitor Analogue TIR-203 Exhibits Enhanced Biological Activity in Multiple Myeloma and Neuroblastoma," Pharm. Biol., 50, 25 (2012). Link Yongfeng Zhao, Michael C. Pirrung, and Jiayu Liao, "A Fluorescent Amino Acid Probe to Monitor Efficiency of Peptide Conjugation to Glass Surfaces for High Density Microarrays," Mol. Biosyst., 8, 879 (2012). Link Michael C. Pirrung, Fa Zhang, Sudhakar Ambadi, and Tannya R. Ibarra-Rivera, "Reactive Esters in Amide Ligation with b-Hydroxyamines," Eur. J. Org. Chem., 4283 (2012). Link Tannya R. Ibarra-Rivera, John Opoku-Ansah, Sudhakar Ambadi, André S. Bachmann, and Michael C. Pirrung, "Synthesis and Cytotoxicity of Syringolin B-Based Proteasome Inhibitors," Tetrahedron, 67, 9950 (2011). Link Ashish Anshu, Simmy Thomas, Puneet Agarwal, Tannya R. Ibarra-Rivera, Michael C. Pirrung, Axel H. Schönthal, "Novel Proteasome-Inhibitory Syrbactin Analogs That Trigger Endoplasmic Reticulum Stress and Induce Apoptosis in Hematological Tumor Cell Lines," Biochem. Pharmacol. 82, 600 (2011). Link Michael C. Pirrung, Timothy M. Dore, Vipul S. Rana, and Yue Zhu, "Sensitized Two-photon Photochemical Deprotection," Chem. Commun., 5313 (2010). Link Michael C. Pirrung, Goutam Biswas, and Tannya R. Ibarra-Rivera, "Total Synthesis of Syringolin A and B," Org. Lett., 12, 2402 (2010). Link Michael C. Pirrung, Biswajit G. Roy, and Surendra Gadamsetty, "Structure-Reactivity Relationships in (2-Hydroxyethyl)benzophenone Photoremovable Protecting Groups," Tetrahedron, 66, 3147 (2010). Link Marci Surpin, Yunfan Zou, Chiyi Xiong, Natasha V. Raikhel, and Michael C. Pirrung, "Iodine Scanning of a Phenazine Inhibitor of Vacuolar Sorting," Bioorg. Med. Chem. Lett., 20, 1496 (2010). Link Michael C. Pirrung and Jianmei Wang, "Multicomponent Reactions of Cyclobutanones," J. Org. Chem., 74, 2958 (2009). Link Michael C. Pirrung, Subir Ghorai, and Tannya R. Ibarra-Rivera, "Multicomponent Reactions of Convertible Isonitriles," J. Org. Chem., 74, 4110 (2009).Link Nicholas J. G. Webster and Michael C. Pirrung, "Small Molecule Activators of the Trk Receptors for Neuroprotection," BMC Neurosci., 9 (Suppl. 2), S1 (2008). Link Michael C. Pirrung, Koushik Das Sarma and Jianmei Wang, "Hydrophobicity and Mixing Effects on Select Heterogeneous, Water-Accelerated Synthetic Reactions," J. Org. Chem., 73, 8723 (2008). Link Michael C. Pirrung, Anthony B. Bleecker, Yoshihisa Inoue, Fernando Rodríguez, Norimitsu Sugawara, Takehiko Wada, Yunfan Zou, and Brad M. Binder, "Ethylene Receptor Antagonists: Strained Alkenes Are Necessary But Not Sufficient," Chem. Biol., 15, 313 (2008). Link Yunfan Zou, Marcela Rojas-Pierce, Natasha V. Raikhel, and Michael C. Pirrung, "Preparation of Methyl Ester Precursors of Biologically Active Agents," BioTechniques, 44, 377 (2008). Link Xin Xiong and Michael C. Pirrung, "Modular Synthesis of Candidate Indole-based Insulin Mimics by Claisen Rearrangement," Org. Lett., 10, 1151 (2008). Link Michael C. Pirrung, Liu Deng, Bo Lin, and Nicholas J. G. Webster, "Quinone Replacements for Small Molecule Insulin Mimics," Chembiochem, 9, 360 (2008). Link Bo Lin, Zhitao Li, Kaapjoo Park, Liu Deng, Ashok Pai, Ling Zhong, Michael C. Pirrung, and Nicholas J. G. Webster, "Identification of Novel Orally-available Small Molecule Insulin Mimics," J. Pharmacol. Exp. Ther., 323, 579 (2007). Link