臧奕 - 中国科学院上海药物研究所 -

个人简介

2001年毕业于复旦大学医学院（原上海医科大学），获医学学士学位。同年7月进入中国科学院上海药物研究所国家新药筛选中心工作。2003年-2008年，中国科学院上海药物研究所研究生，获博士学位。2008年-2010年，美国M.D.Anderson肿瘤研究中心博士后。2010年10月被中国科学院上海药物研究所聘为副研究员，硕士研究生导师，2014年10月被聘为研究员。目前已在J Biol Chem, Adv Mater, Chem Sci, Chem Soc Rev, Chem Commun (Camb), Mol Cancer Res, J Clin Invest等国际期刊上发表论文48篇，其中第一作者文章4篇，共同通讯作者文章10篇，申请专利2项。作为课题负责人完成上海市自然科学基金、国家自然科学基金资助青年项目和国家自然科学基金面上项目各一项。正在主持国家科技重大新药创制项目子任务, 一项国家自然科学基金面上项目，一项上海市科委国际合作项目及中科院“个性化药物”先导专项子课题。作为主要技术骨干人员参与完成国家重大科学研究计划发育与生殖专项项目、中国科学院战略性先导科技“干细胞与再生医学研究”专项等。

研究领域

1. 细胞识别和细胞命运调控化学生物学研究； 2. 基于AMPK激酶家族信号调控网络的基础研究； 3. 纤维化疾病创新药物发现及评价研究； 4. 基于表观遗传新靶点的创新药物发现及评价研究；

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Li KB, Li N, Zang Y, Chen GR, Li J*, James TD, He XP*, Tian H, Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules Chem. Sci., 2016, 7, 6325 IF/5-IF: 9.144/9.155 cited: 0 Ji DK, Zhang Y, Zang Y, Li J*, Chen GR, He XP*, Tian H Targeted Intracellular Production of Reactive Oxygen Species by a 2D Molybdenum Disulfide Glycosheet. Adv Mater. 2016 Aug 29. IF/5-IF:18.96/18.862 cited: 0 Hu XL, Zang Y, Li J*, Chen GR, James TD, He XP*, Tian H, Targeted multimodal theranostics via biorecognition controlled aggregation of metallic nanoparticle composites. Chem Sci 2016,7, 4004-4008 Deo C, Wang H , Bogliotti N, Zang Y*, Retailleau P, He XP*, Li J, Xie J* Photoswitchable arene ruthenium and pentamethylcyclopentadienyl rhodium complexes containing o-sulfonamide azobenzene ligands: Synthesis, characterization and cytotoxicity. Journal of Organometallic Chemistry, 2016, 820: 111-119. IF/5-IF: 2.336/2.09 cited: 0 Cheng J, Liu M, Shao BH, Zhang S, Li J, Hu YZ, Li X*, Zang Y*, Development of a novel H2S and GSH detection cocktail for fluorescence imaging. RSC Advances, 2016, 6, 59882-59888 IF/5-IF: 3.289/3.485 cited: 1 Ji DK#, Zhang Y#, Zang Y*, Liu W， Zhang XW, Li J*, Chen GR, James，TD， He XP* Receptor-targeting fluorescence imaging and theranostics using a graphene oxide based supramolecular glycocomposite. J. Mater. Chem. B, 2015,3, 9182-9185 IF/5-IF: 4.872 /4.879 cited: 12 Dong L#, Zang Y#, Zhou D, He XP*, Chen GR, James TD, Li J* Glycosylation enhances the aqueous sensitivity and lowers the cytotoxicity of a naphthalimide zinc ion fluorescence probe. Chem Commun (Camb). 2015, 51:11852-5 IF/5-IF: 6.567/6.628 cited: 19 He XP#, Zang Y, James TD, Li J* and Chen GR* (2015) Probing disease-related proteins with fluorogenic composite materials Chem Soc Rev 2015 Jul 7;44(13):4239-4 IF/5-IF: 34.09/36.63 cited: 44 He XP*，Zhu BW，Zang Y，Li J*, Chen GR, Tian H, Long YT* , Dynamic tracking of pathogenic receptor expression of live cells using pyrenyl glycoanthraquinone-decorated grapheme electrodes. Chem. Sci., 2015, 6, 1996 IF/5-IF: 9.144 /9.155 cited: 21 Zhang L#, Wang JC, Hou L, Cao PR, Wu L, Zhang QS, Yang HY, Zang Y*, Ding JP*, Li J*. Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases. Sci Rep. 2015 May 11;5:10115. IF/5-IF: 5.228/5.525 cited: 2 Deng SS#, Zhang C#, Wang H, Zang Y*, Li J, He XP*, Chen GR. Mixed galactolipid anomers accentuate apoptosis of multiple myeloma cells by inducing DNA damage. Carbohydr Res. 2015 May 18;408:114-8. IF/5-IF: 1.817/2.023 cited:1 Deng SS#, Wu LY#, Wang YC, Cao PR, Xu L, Li QR, Liu M, Zhang L, Jiang YJ, Yang XY, Sun SN, Tan MJ, Qian M, Zang Y*, Feng L*, Li J*. Protein kinase A rescues Microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating Serine 409. J Biol Chem. 2015 Jan 30;290(5):3149-60 IF/5-IF: 4.258/4.403 cited:0 Li KB#, Zang Y#, Wang H, Li J*, Chen GR, James TD, He XP*, Tian H.Hepatoma-selective imaging of heavy metal ions using a 'clicked' galactosyl rhodamine probe. Chem Commun (Camb). 2014, 50:11735-7 IF/5-IF: 6.567/6.628 cited: 5 Cheng CY#, Feng YY, Zang Y*, Li J, He XP*, Chen GR, Identification of a new bis-amino acid glycoside selectively toxic to multiple myeloma cells. Carbohydr Res 2014, 394:39-42 IF/5-IF: 1.817/2.023 cited: 1 He XP#, Deng Q, Cai L, Wang CZ, Zang Y*, Li J*, Chen GR*, Tian H. Fluorogenic resveratrol-confined graphene oxide for economic and rapid detection of Alzheimer's disease. ACS Appl Mater Interfaces. 2014, 6:5379-82. IF/5-IF: 7.145/7.332 cited: 25 Li KB#, Wei XL, Zang Y*, He XP*, Chen GR, Li J* and Chen KX. Revisit of a dipropargyl rhodamine probe reveals it alternative ion sensitivity in both a solution and live cells. Analyst 2013 Dec 7;138(23):7087-9 IF/5-IF: 4.033/4.092 cited: 7 Zhang HL#, Wei XL, Zang Y, Cao JY, Liu S, He XP*, Chen Q, Long YT, Li J*, Chen GR*, Chen K. Fluorogenic Probing of Specific Recognitions between Sugar Ligands and Glycoprotein Receptors on Cancer Cells by an Economic Graphene Nanocomposite. Adv Mater. 2013, 25:4097-101. IF/5-IF: 18.96/18.862 cited: 48