个人简介

University of Rochester - B.S. (1988) University of Cambridge - C.P.G.S. (1989) California Institute of Technology - Ph.D. (1997) Massachusetts Institute of Technology - ACS Postdoc. Fellow (1996-1998)

研究领域

Chemical Biology/Computational Chemistry/Physical Chemistry

My research group is advancing the characterization of molecular structure and dynamics and exploring new applications of magnetic resonance to chemical physics. While nuclear magnetic resonance (NMR) is the centerpiece of our work, we also make considerable use of ab initio computational theory and an underlying theme of our work is how NMR fits into a larger framework for constructing and quantitatively testing chemically-detailed models of structure and conformational dynamics. Current research in my group focuses on the following: (1) NMR crystallography: from organic molecular crystals to enzymatic intermediates in the active site of tryptophan synthase; (2) structure and dynamics with solid-state NMR, emphasizing the development of novel experimental and theoretical methods with applications to materials and biological solids; (3) dynamic NMR: new applications to kinetic and thermodynamic studies of DNA and carbohydrates in solution; and (4) NMR pedagogy.

近期论文

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L.J. Mueller and M.F. Dunn, "NMR Crystallography of Enzyme Active Sites: Probing Chemically-Detailed, Three-Dimensional Structure in Tryptophan Synthase," Accounts of Chemical Research, 2013, in press　 T. Kim , L. Zhu , L.J. Mueller, and C.J. Bardeen, "Dependence of the solid-state photomechanical response of 4-chlorocinnamic acid on crystal shape and size," CrystEngComm 2012, 14, 7792-7799 D.J. Langeslay, R.P. Young, S. Beni, C.N. Beecher, L.J. Mueller, and C.K. Larive, "Sulfamate Proton Solvent Exchange in Heparin Oligosaccharides: Evidence for a Persistent Hydrogen Bond in the Antithrombin-Binding Pentasaccharide Arixtra," Glycobiology 2012, 22(9), 1173-1182 G Beran, E.L. Chronister, L.L. Daemen, A.R. Moehlig, L.J. Mueller, J. Oomens, A. Rice, D. Santiago-Dieppa, F.S. Tham, K. Theel, S. Yaghmaeia, and T.H. Morton, "Vibrations of a Chelated Proton in a Protonated Tertiary Diamine," Physical Chemistry Chemical Physics 2011, 13, 20380-20392 L.J. Mueller, "Tensors and Rotations in NMR," Concepts in Magnetic Resonance Part A 2011, 38A, 221-235 L. Zhu, A. Agarwal, J. Lai, R.O. Al-Kaysi, F.S. Tham, T. Ghaddar, L. Mueller, C.J. Bardeen, "Solid-state Photochemical and Photomechanical Properties of Molecular Crystal Nanorods Composed of Anthracene Ester Derivatives," Journal of Materials Chemistry 2011, 21(17), 6258-6268 J. Lai, D. Niks, Y. Wang, T. Domratcheva, T.R.M. Barends, F. Schwarz, R.A. Olsen, D.W. Elliott, M.Q. Fatmi, C.A. Chang, I. Schlichting, M.F. Dunn, and L.J. Mueller, "X-Ray and NMR Crystallography in an Enzyme Active Site: the Indoline Quinonoid Intermediate in Tryptophan Synthase," Journal of the American Chemical Society 2011, 133, 4-7 M. Tang, G. Comellas, L.J. Mueller, and C.M. Rienstra, "High Resolution 13C-Detected Solid-State NMR Spectroscopy of a Deuterated Protein," Journal of Biological NMR 2010, 48(2), 103-111 R. Liu, Y. Zhang, X. Zhao, A. Agarwal, L.J. Mueller, and P. Feng, "pH-Responsive Nanogated Ensemble Based on Gold-Capped Mesoporous Silica through an Acid-Labile Acetal Linker," Journal of the American Chemical Society 2010, 132(5), 1500-1501 L.J. Mueller and J.J. Titman, "Correlation Spectroscopy for Resonance Assignments in Solid-State Proteins Using J Couplings," in D.M. Grant, R.K. Harris (Eds.), Encyclopedia of Magnetic Resonance, John Wiley & Sons, Ltd., Chichester, DOI: 10.1002/9780470034590.emrstm1094, 2010 J. Lai, Z. Ma, L. Mink, L.J. Mueller, and F. Zaera, "Influence of Peripheral Groups on the Physical and Chemical Behavior of Cinchona Alkaloids," Journal of Physical Chemistry B 2009, 113(34), 11696-11701 Y. Tian, L. Chen, D. Niks, J.M. Kaiser, J. Lai, C.M. Rienstra, M.F. Dunn, and L.J. Mueller, "J-Based 3D Sidechain Correlation in Solid-State Proteins," Physical Chemistry Chemical Physics 2009, 11(32), 7078-7086 D. Lee, J. Struppe, D.W. Elliott, L.J. Mueller, and J.J. Titman, "Sensitive Absorptive Refocused Scalar Correlation NMR Spectroscopy in Solids," Physical Chemistry Chemical Physics 2009, 11(18), 3547–3553 Y. Tian, M. Kayatta, K. Shultis, A. Gonzalez, L.J. Mueller, and M.E. Hatcher, "NMR Investigation of Backbone Dynamics in DNA Binding Sites," Journal of Physical Chemistry B 2009, 113(9), 2596-2603 S. Yaghmaei, S. Khodagholian, J.M. Kaiser, F.S. Tham, L.J. Mueller, and T.H. Morton, "Chelation of a Proton by an Aliphatic Tertiary Diamine," Journal of the American Chemical Society 2008, 130(25), 7836-7838 L. Mink, Z. Ma, R.A. Olsen, J.N. James, D.S. Sholl, L.J. Mueller, and F. Zaera, "The Physico-Chemical Properties of Cinchona Alkaloids Responsible for their Unique Performance in Chiral Catalysis," Topics in Catalysis 2008, 48(1-4), 120-127 L. Chen, J.M. Kaiser, J. Lai, T. Polenova, J. Yang, C.M. Rienstra, and L.J Mueller, "J – Based 2D Homonuclear and Heteronuclear Correlation in Solid-State Proteins," Magnetic Resonance in Chemistry 2007, 45, S84-S92 R.O. Al-Kaysi, R.J. Dillon, J.M. Kaiser, L.J. Mueller, G. Guirado, and C.J. Bardeen, "Photopolymerization of Organic Molecular Crystal Nanorods," Macromolecules 2007, 40, 9040-9044 L. Chen, J.M. Kaiser, T. Polenova, J. Yang, C.M. Rienstra, and L.J Mueller, "Backbone Assignments in Solid-State Proteins Using J-Based 3D Heteronuclear Correlation Spectroscopy," Journal of the American Chemical Society 2007, 129(35), 10650-10651 X. Wang, D. Lu, R. Austin, A. Agarwal, L.J. Mueller, Z. Liu, J. Wu, and P. Feng, "Protein Refolding Assisted by Periodic Mesoporous Organosilicas," Langmuir 2007, 23(10), 5735-5739