个人简介

University of British Columbia, B.Sc. in Chemistry (2005) University of California, Irvine - Ph.D. in Chemistry (2011) Princeton University - Postdoc. (2011 - 2014) Awards Bristol-Myers Squibb Graduate Fellowship, 2010. Roche Excellence in Chemistry Graduate Student Award, 2010. NSERC Canadian Postgraduate Scholarship, 2009-2011. Eli Lilly Graduate Fellowship, 2009. Society of Chemical Industry Merit Prize, 2005. Pierre Berthier Education Abroad Scholarship, 2002. Bronze medal, International Chemistry Olympiad in Denmark, July 2000

研究领域

Organic Chemistry

Research in the Martin lab will focus on the development of new catalytic transformations and novel strategies for bond activation. Our goal will be to identify reactions that are both broadly useful and provide new avenues for the synthesis of structurally complex natural products and pharmaceutical agents. We will find inspiration both through the identification of bioactive natural product targets, and through consideration of larger problems where organic chemistry is poised to offer practical solutions (eg. degradation and selective functionalization of biomass). A major focus of the lab will be to explore general approaches to families of natural products where promising biological activity has been reported, in particular in the area of neuroregenerative and neuroprotective molecules. In addition to chemical synthesis, we will pursue studies of their mechanism of action and initiate collaborative studies where appropriate.

近期论文

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Michael T. Pirnot, Danica A. Rankic, David B. C. Martin, David W. C. MacMillan. "Photoredox Activation for the Direct beta-Arylation of Ketones and Aldehydes." Science 2013, 339, 1593-1596. David B. C. Martin, Christopher D. Vanderwal. "A Short Synthesis of Strychnine from Pyridine" in Total Synthesis of Natural Products: At the Frontier of Organic Chemistry; Li, J. J. and Corey, E. J. Eds.; Springer: Heidelberg; pp 67-102. Hung V. Pham, David B. C. Martin, Christopher D. Vanderwal, K. N. Houk. "The Intramolecular Diels-Alder Reaction of Tryptamine-Derived Zincke Aldehydes is a Stepwise Reaction." Chem. Sci. 2012, 3, 1650-1655. David B. C. Martin, Lucas Q. Nguyen, Christopher D. Vanderwal. "Syntheses of Strychnine, Norfluorocurarine, Dehydrodesacetylretuline, and Valparicine Enabled by Formal Intramolecular Cycloadditions of Zincke Aldehydes." J. Org. Chem. 2012, 77, 17-46. David B. C. Martin, Christopher D. Vanderwal. "A Synthesis of Strychnine by a Longest Linear Sequence of Six Steps." Chem. Sci. 2011, 2, 649-651. David B. C. Martin, Christopher D. Vanderwal. "Efficient Access to the Core of the Strychnos, Aspidosperma and Iboga Alkaloids. A Short Synthesis of Norfluorocurarine." J. Am. Chem. Soc. 2009, 131, 3472-3473.