个人简介

University of Virginia - B.S. in Chemistry (Highest Distinction, 2004) University of California, Berkeley - Ph.D. in Chemistry (2010) California Institute of Technology - Postdoc. Fellow (2010 - 2013) Awards NSF CCI Postdoctoral Fellow 2010-2013 Arkema Graduate Fellowship 2005-2006 Phi Beta Kappa 2003 Barry M. Goldwater Scholarship 2003 University of Virginia Undergraduate Teaching Award 2004 University of Virginia Faculty Senate Harrison Research Grant 2003 University of Virginia College of Arts and Sciences Research Grant 2002

研究领域

Inorganic Chemistry/Organic Chemistry

The global need for carbon-neutral energy and chemical technologies of reduced environmental impact insure that catalysis will remain at the forefront of chemical research for the foreseeable future. As synthetic chemists, we are developing new reaction centers based on the d- and p-block elements for the catalysis of chemical reactions relevant to these broad goals, such as the storage of electrical current as chemical fuels (electrocatalytic H+ and CO2 reduction), hydrocarbon conversions (C-H activation), and the transformation of renewable biomass to liquid fuels (hydrodeoxygenation). In nature, metalloenzymes catalyze many of these reactions with superb activity using earth abundant transition metal centers. Taking inspiration from these complex active sites, yet unconstrained by the biological milieu, we seek to deploy the principles by which these active sites function in a totally synthetic context. In particular, we are interested in the cooperative activation of substrates towards catalysis, whether with multiple metal centers, Lewis acid-base interactions, or hydrogen bonding. Along the way, we expect to uncover fundamentally new bonding motifs and transformations of small molecules in the coordination sphere of a metal complex. Our ultimate goal is to expand scientific knowledge of inorganic reactivity and catalyst design, exploiting principles of cooperativity to create synthetic catalysts from abundant elements with activities that rival those of metalloenzymes.

近期论文

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Harman, W. H.; Lin, T.-P.; Peters, J. C. "A d10 Ni–(H2) Adduct as an Intermediate in H–H Oxidative Addition across a Ni–B Bond." Angew. Chem. Int. Ed. 2014, 53, 1081-1086. MacMillan, S. N.; Harman, W. H.; Peters, J. C. "Facile Si–H bond activation and hydrosilylation catalysis mediated by a nickel–borane complex," Chem. Sci. 2014, 5, 590–597. Harman, W. H.; Lichterman, M. F.; Piro, N. A.; Chang, C. J. "Well-Defined Vanadium Organoazide Complexes and Their Conversion to Terminal Vanadium Imides: Structural Snapshots and Evidence for a Nitrene Capture Mechanism," Inorg. Chem. 2012, 51, 10037–10042. Harman, W. H.; Peters, J. C. "Reversible H2 Addition Across a Nickel–Borane Unit as a Promising Strategy for Catalysis," J. Am. Chem. Soc. 2012, 134, 5080–5082. Bigi, J. P.; Harman, W. H.; Lassalle-Kaiser, B.; Robles, D. M.; Stich, T. A.; Yano, J.; Britt, R. D.; Chang, C. J. "A High-Spin Iron(IV)-Oxo Complex Supported by a Nonheme Pyrrolide Platform," J. Am. Chem. Soc. 2012, 134, 1536–1542. Piro, N. A.; Lichterman, M. F.; Harman, W. H.; Chang, C. J. "A Structurally Characterized Nitrous Oxide Complex of Vanadium," J. Am. Chem. Soc. 2011, 133, 2108–2111. Harman, W. H.; Harris, T. D.; Freedman, D. E.; Fong, H.; Chang, A.; Rinehart, J. D.; Ozarowski, A.; Sougrati, M. T.; Grandjean, F.; Long, G. J.; Long, J. R.; Chang, C. J. "Slow Magnetic Relaxation in a Family of Trigonal Pyramidal Iron(II) Pyrrolide Complexes," J. Am. Chem. Soc. 2010, 132, 18115–18126. Bigi, J. P; Hanna, T. E.; Harman, W. H.; Chang, A.; Chang, C. J. "Electrocatalytic reduction of protons to hydrogen by a water-compatible cobalt polypyridyl platform," Chem. Commun. 2010, 46, 958–960. Freedman, D. E.; Harman, W. H.; Harris, T. D.; Long, G. J.; Chang, C. J.; Long, J. R. "Slow Magnetic Relaxation in a High-Spin Iron(II) Complex," J. Am. Chem. Soc. 2010, 132, 1224–1225. Harman, W. H.; Chang, C. J. "N2O Activation and Oxidation Reactivity from a Nonheme Iron Pyrrole Platform," J. Am. Chem. Soc. 2007, 129, 15128–15129. Kazhdan, D.; Chomitz, W. A.; Harman, W. H.; Hoette, T. M.; Park, C.-H. "(Bipyridyl-κ2N,N’)bis(η5-pentamethylcyclopentadienyl)(trifluoromethanesulfonato- κO)cerium(III). Acta Crystallogr., Sect. E: Struct. Rep. Online 2007, E63, m1656. Delafuente, D. A.; Kosturko, G. W.; Graham, P. M.; Harman, W. H.; Myers, W. H.; Surendranath, Y.; Klet, R. C.; Welch, K. D.; Trindle, C. O.; Sabat, M.; Harman, W. D. "Isomerization Dynamics and Control of the η2/N Equilibrium for Pyridine Complexes," J. Am. Chem. Soc. 2007, 129, 406-416. Surendranath, Y.; Welch, K. D.; Nash, B. W.; Harman, W. H.; Myers, W. H.; Harman, W. D. "Tungsten-Promoted Dearomatization of Heterocycles: Uncovering the Latent 2-Azadiene Character of Pyrimidines," Organometallics 2006, 25, 5852–5853.