个人简介

Swarthmore College - B.A. (2001) University of California, Irvine - B.S. (2002) California Institute of Technology - PhD (2003-2009) The Scripps Research Institute - Postdoc. Fellow (2010-2015)

研究领域

Analytical Chemistry/Chemical Biology

We are interested in developing in situ quantitative techniques that interrogate the folding, assembly, and misfolding of lipoprotein complexes that are the best molecular signatures of atherosclerotic risk. These will then be applied to attain mechanistic understanding that can lead to new therapeutic and diagnostic approaches for cardiovascular diseases. Ongoing projects include Integrating in situ analytical techniques with multiplexed quantitative proteomics to relate molecular proteostasis pathways to the properties of secreted lipoprotein particles. Molecular characterization of how physiologically relevant oxidation products induce aggregation and enhance atherogenicity of LDL Development of quantitative unbiased proteomic assays to both measure and characterize protein homeostasis in living cells. These will be applied to establish molecular etiologies and identify therapeutic targets for cardiovascular, neurodegenerative, and cancer diseases.

近期论文

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Genereux, J.C.; Augustyn, K.E.; Davis, M.L.; Shao, F.; Barton, J.K. "Back Electron Transfer Suppresses the Periodic Length Dependence of DNA-mediated Charge Transport Across Adenine Tracts", J. Am. Chem. Soc. (2008) 130, 15150. Boal, A.K.; Genereux, J.C.; Sontz, P.A.; Gralnick, J.A.; Newman, D.K.; Barton, J.K. "Redox Signaling between DNA Repair Proteins for Efficient Lesion Detection", Proc. Natl. Acad. Sci. USA (2009) 106, 15237. Genereux, J.C.; Barton, J.K. "Mechanisms of Long-range DNA-mediated Charge Transport", Chem. Rev. (2010) 110, 1642. Genereux, J.C.; Boal, A.K.; Barton, J.K. "DNA-mediated Charge Transport in Redox Sensing and Signaling", J. Am. Chem. Soc. (2010) 132, 891. Genereux, J.C.; Wuerth, S.M.; Barton, J.K. "Single-Step Charge Transport through DNA over Long Distances" J. Am. Chem. Soc. (2011) 133, 3863. Shoulders, M.D.; Ryno, L.M.; Genereux, J.C.; Moresco, J.J.; Tu, P.G.; Wu, C.; Yates, J.R.; Su, A.I.; Kelly, J.W.; Wiseman, R.L. "Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments" Cell Rep. (2013), 3, 1279. Rainbolt, T.K.; Atanassova, N.; Genereux, J.C.; Wiseman, R.L. "Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import Through Tim17A Degradation", Cell Metabolism (2013), 18, 908. Ryno, L.M.; Genereux, J.C.; Naito, T.: Morimoto, R.I.; Powers, E.T.; Shoulders, M.D.; Wiseman, R.L. "Characterizing the Altered Cellular Proteome Induced by the Stress-Independent Activation of Heat Shock Factor 1", ACS Chem. Biol. (2014), 9, 1273. Tan, Y.-L.; Genereux, J.C.; Pankow, S.; Aerts, J.M.F.G.; Yates III, J.R.; Kelly, J.W. "ERdj3 is an Endoplasmic Reticulum Degradation versus Folding Partitioning Factor for Mutant Glucocerebrosidases Linked to Gaucher’s Disease", Chem. Biol., (2014), 21, 967. Zhang, X.; Liu, Y.; Genereux, J.C.; Nolan, C.; Singh, M.; Kelly, J.W. "Heat-Shock Response Transcriptional Program Enables High-Yield and High-Quality Recombinant Protein Production in Escherichia coli", ACS Chem. Biol., (2014), 9, 1945. Chen. J.C.*; Genereux, J.C.*; Qu, S.; Hulleman, J.D.; Shoulders, M.D.; Wiseman, R.L. "ATF6 Activation Reduces the Secretion and Extracellular Aggregation of Destabilized Variants of an Amyloidogenic Protein", Chem. Biol., (2014), 21, 1564. * indicates co-first author. Genereux, J.C.; Qu, S.; Zhou, M.; Ryno, L.M.; Wang, S.; Shoulders, M.S.; Kaufman, R.J., Kelly, J.W., Lasmezas, C.I.; Wiseman, R.L. "ERdj3 is an Unfolded Protein Response-Induced Secreted Chaperone that Increases Extracellular Proteostasis Capacity", EMBO J., (2015), 34, 4. Genereux, J.C.; Wiseman, R.L. "Regulating Extracellular Proteostasis Capacity Through the Unfolded Protein Response", Prion, (2015), in press