Piper, Matt - Monash University - School of Biological Sciences

研究领域

Food quantity and nutrient quality affect the behaviour, health and lifespan of all organisms. Matt's research focuses on the fruit fly Drosophila melanogaster to investigate the molecular mechanisms that mediate these effects, with the goal of understanding these processes in humans.

近期论文

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Lifespan extension by dietary restriction is associated with GATA motifs and organ-specific, TOR-dependent transcriptional networks Dobson, A.J., He, X., Blanc, E., Bolukbasi, E., Yang, M. & Piper, M.D.W. [2016] Lifespan extension by dietary restriction is associated with GATA motifs and organ-specific, TOR-dependent transcriptional networks. BioRxiv. doi: 10.1101/036848 Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Afschar, S., Toivonen, J.M., Hoffmann, J., Tain, L.S., Wieser, D., Finlayson, A.J., Dreige, Y., Alic, N., Emran, S., Stinn, J., Froehlich, J., Piper, M.D.W.* & Partridge, L.* [2016] Nuclear hormone receptor DHR96 mediates the resistance to xenobiotics but not the increased lifespan of insulin-mutant Drosophila. Proceedings of the National Academy of Sciences, USA, doi:10.1073/pnas.1515137113 (*co-corresponding author) Quantifly: robust trainable software for automated Drosophila egg counting. Waithe, D., Rennert, P., Brostow, G. & Piper, M.D.W. [2015] Quantifly: robust trainable software for automated Drosophila egg counting. PLoS One, doi:10.1371/journal.pone.0127659 Using doubly-labelled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster. Piper, M.D.W., Selman, C., Speakman, J.R. & Partridge, L [2014] Using doubly-labelled water to measure energy expenditure in an important small ectotherm Drosophila melanogaster. Journal of Genetics and Genomics, 41, 505-512. doi:doi:10.1016/j.jgg.2014.07.004 Target of Rapamycin Signalling Mediates the Lifespan-Extending Effects of Dietary Restriction by Essential Amino Acid Alteration. Emran, S., Yang, M., He, X., Zandveld, J. & Piper, M.D.W. [2014] Target of Rapamycin Signalling Mediates the Lifespan-Extending Effects of Dietary Restriction by Essential Amino Acid Alteration. Aging, 6, 1-9. A holidic medium for Drosophila melanogaster. Piper, M.D.W., Blanc, E., Leitão-Gonçalves, R., Yang, M, He, X, Linford, N.J., Hoddinott, M.P., Hopfen, C, Soultoukis, G.A., Niemeyer, C, Kerr, F, Pletcher, S.D., Ribeiro, C. & Partridge, L [2014] A holidic medium for Drosophila melanogaster. Nature Methods, 11, 100-105. doi:10.1038/nmeth.2731 Analysing variation in Drosophila ageing across independent experimental studies – a meta-analysis of survival data. Zeihm, M, Piper, M.D.W., & Thornton, J.M. [2013] Analysing variation in Drosophila ageing across independent experimental studies – a meta-analysis of survival data. Aging Cell, 12, 917-922. doi:10.1111/acel.12123 Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. Alic, N., Hoddinott, M.H., Foley, A., Slack, C., Piper, M.D.W. & Partridge, L. [2012] Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies. PloS One, 7, e45367. doi:10.1371/journal.pone.0045367