McGraw, Beth - Monash University - School of Biological Sciences

研究领域

My laboratory is interested in understanding the evolution of insect:microbe interactions from the perspective of the insect host. We commonly use Drosophila as a model to study bacteria that range from mutualists to pathogens. In a more applied context we are also studying the effects of a bacterial symbiont on mosquitoes that is being developed for biocontrol against dengue virus. We use a combination of molecular biology, genomics, and experimental approaches to examine •Insect x symbiont x pathogen interactions •The genetic basis of pathogen transmission in insect vectors •The relationship between infection and fitness in insects

近期论文

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Woolfit, M., Algama Appohamilage Dona, M.D., Keith, J.M., McGraw, E.A., Popovici, J.O.O., 2015, Discovery of putative small non-coding RNAs from the obligate intracellular bacterium Wolbachia pipientis, PLoS ONE [E], vol 10, issue 3, Public Library of Science, San Francisco CA USA, pp. 1-19. Amuzu, H.E.K., Simmons, C.P., McGraw, E.A., 2015, Effect of repeat human blood feeding on Wolbachia density and dengue virus infection in Aedes aegypti, Parasites & Vectors [E], vol 8, issue 1, BioMed Central, London UK, pp. 1-9. Ferguson, N.M., Kien, D.T.H., Clapham, H., Aguas, R., Trung, V.T., Chau, T.N.B., Popovici, J.O.O., Ryan, P.A., O'Neill, S.L., McGraw, E.A., Long, V.T., Dui, L.T., Nguyen, H.L., Chau, N.V.V., Wills, B., Simmons, C.P., 2015, Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti, Science Translational Medicine [P], vol 7, issue 279, American Association for the Advancement of Science (A A A S), Washington DC USA, pp. 1-13. Ye, Y., Carrasco, A.M., Frentiu, F., Chenoweth, S., Beebe, N.W., van der Hurk, A.F., Simmons, C.P., O'Neill, S.L., McGraw, E.A., 2015, Wolbachia reduces the transmission potential of dengue-infected Aedes aegypti, Public Library of science: Neglected Tropical Diseases [P], vol 9, issue 6, Public Library of Science, San Francisco CA USA, pp. 1-19. Ye, Y., Ng, T., Frentiu, F., Walker, T., van den Hurk, A.F., O'Neill, S.L., Beebe, N.W., McGraw, E.A., 2014, Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus, American Journal of Tropical Medicine and Hygiene [P], vol 90, issue 3, American Society of Tropical Medicine and Hygiene, United States, pp. 422-430. Caragata, E.P., Rances, E., O'Neill, S.L., McGraw, E.A., 2014, Competition for amino acids between Wolbachia and the mosquito host, Aedes aegypti, Microbial Ecology [P], vol 67, issue 1, Springer, United States, pp. 205-218. Frentiu, F., Zakir, T.S., Walker, T., Popovici, J.O.O., Pyke, A.T., van den Hurk, A.F., McGraw, E.A., O'Neill, S.L., 2014, Limited Dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia, PL o S Neglected Tropical Diseases [E], vol 8, issue 2, Public Library of Science, California United States, pp. 1-10.