Bryson-Richardson, Rob - Monash University - School of Biological Sciences

研究领域

Robert's research focuses on the genetics and cell biology of muscle development and disease. His team uses zebrafish, which grow very rapidly and are transparent when young, to study these processes. Generating zebrafish models of muscle disease allows them to investigate how muscle function is disrupted improving our understanding of both normal muscle development and of the causes of muscle disease. Additionally these fish can be used to test therapies and to identify effective drugs treatments.

近期论文

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Sztal TE, Ruparelia AA, Williams C, Bryson-Richardson RJ (2016) Using touch-evoked response and locomotion assays to assess muscle performance and function in zebrafish. J Vis Exp In Press Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, Fürst DO (2016) Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Hum Mol Genet. May 19. Early Access Kozlovsky P, Bryson-Richardson RJ, Jaffa AJ, Rosenfeld M, Elad D (2016) The Driving Mechanism for Unidirectional Blood Flow in the Tubular Embryonic Heart. AnnBiomed Eng. 2016 Apr 25. Advance access Ruparelia AA, Oorschot V, Ramm G, Bryson-Richardson RJ (2016) FLNC myofibrillar myopathy results from impaired autophagy and protein insufficiency. Hum Mol Genet Mar 11 Early Access DJ Klionsky, K Abdelmohsen, A Abe, MJ Abedin, H Abeliovich,… Bryson-Richardson RJ, ….. et al., (2016) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 12 (1) 1-222 Sztal TE, Zhao M, Williams C, Oorschot V, Parslow AC, Giousoh A, Yuen M, Hall TE, Costin A, Ramm G, Bird PI, Busch-Nentwich EM, Stemple DL, Currie PD, Cooper ST, Laing NG, Nowak KJ, Bryson-Richardson RJ (2015) Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathol 130 (3) 389-406 Giousoh A, Vaz R, Bryson-Richardson RJ, Whisstock JC, Verkade H, Bird PI (2015) Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene Exp Patterns 18 (1-2) 37-43 Pelliccia D, Vaz R, Svalbe I, Morgan KS, Marathe S, Xiao X, Assoufid L, Anderson RA, Topczewski J, Bryson-Richardson RJ (2015) Comparison of different numerical treatments for x-ray phase tomography of soft tissue from differential phase projections. Phys. Med. Biol. 60 (8) 365