研究领域

Arthritis, Autophagy, Dendritic Cell, Immunity, Inflammation, Lupus, Macrophage, tuberculosis

My specific interestes are the role of autophagy in the regulation of cytokine secretion and inflammation, as well as its role in the response to pathogens, including Mycobacterium tuberculosis, the bacteria that causes tuberculosis in humans. I am also currently investigating the mechanisms through with macrophage migration inhibitory factor (MIF) influences inflammation, particularly in autoimmune diseases. Our reasearch aims are to better understand the mechanisms that control inflammtion in autoimmune diseases such as SLE, arthritis and psoriasis. By gaining a clearer understanding of the molecular pathways that control inflammation, we can develop more targeted therapeutic approaches to the treatment of inflammatory disease.

近期论文

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Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages Lee, J. P. W., Foote, A., Fan, H., Peral de Castro, C., Lang, T., Jones, S. A., Gavrilescu, N., Mills, K. H. G., Leech, M., Morand, E. F. & Harris, J. 2 Jun 2016 In : Autophagy. 12, 6, p. 907 - 916 10 p. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Bryson-Richardson, R. J. , Devenish, R. J. , Harris, J. , Kwok, T. , Osellame, L. D. , Prescott, M. , Ruparelia, A. & 43 others 2016 In : Autophagy. 12, 1, p. 1-222 222 p. AUTOPHAGY REGULATES MIF AND GLUCOCORTICOID SENSITIVITY Morand, E. F., Fan, H., Lang, T., Foote, A. M., Gavrilescu, N., Lee, J. & Harris, J. May 2015 p. 25 GILZ regulates Th17 responses and restrains IL-17-mediated skin inflammation Jones, S., Perera, D. N., Fan, H., Russ, B. E., Harris, J. & Morand, E. F. 2015 In : Journal of Autoimmunity. 61, p. 73 - 80 8 p. Interleukin-38 exerts antiinflammatory functions and is associated with disease activity in systemic lupus erythematosus Rudloff, I., Godsell, J., Nold-Petry, C. A., Harris, J., Hoi, A., Morand, E. F. & Nold, M. F. 2015 In : Arthritis & Rheumatology. 67, 12, p. 3219 - 3225 7 p. MIF: Implications in the Pathoetiology of Systemic Lupus Erythematosus Lang, T., Foote, A. M., Lee, J. P. W., Morand, E. F. & Harris, J. 2015 In : Frontiers in Immunology. 6, Art ID: 577, p. 1 - 10 10 p.