研究领域

Kidney Disease, Inflammation, Fibrosis, Macrophage, Signalling pathways, Pre-clinical studies

Inflammation and fibrosis in kidney disease Kidney disease caused by type 2 diabetes is an emerging epidemic in the developing world. It accounts for 40 per cent of all cases, requiring dialysis or transplants as treatment. Yet many people are not aware that they may be in the early stages of the disease. Doctor David Nikolic-Paterson is helping to find new ways to identify and treat the damage wrought on our kidneys. "There are many different types of kidney disease, which vary in both the underlying cause and in the speed with which they progress to end-stage kidney failure - at which point you require dialysis or a kidney transplant to survive," notes David. "Our research is focused on understanding the disease mechanisms that drive progressive kidney damage, in particular inflammation and fibrosis, and to identify new therapeutic approaches in the treatment of this major health problem. 'We're working in two areas. The first is basic research into the mechanisms of inflammation and fibrosis that underlie the development of many forms of kidney disease. The second area is translation of this basic research towards new clinical therapies.

近期论文

查看导师新发文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

ASK1 inhibitor halts progression of diabetic nephropathy in Nos3-deficient mice Tesch, G. H., Ma, F., Han, Y., Liles, J. T., Breckenridge, D. G. & Nikolic-Paterson, D. J. 2015 In : Diabetes. 64, 11, p. 3903 - 3913 11 p. Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury Ikezumi, Y., Suzuki, T., Yamada, T., Hasegawa, H., Kaneko, U., Hara, M., Yanagihara, T., Nikolic-Paterson, D. J. & Saitoh, A. 2015 In : Pediatric Nephrology. 30, 6, p. 1007 - 1017 11 p. Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis Lee, A., Slattery, C., Nikolic-Paterson, D. J., Hryciw, D. H., Wilk, S., Wilk, E., Zhang, Y., Valova, V. A., Robinson, P. J., Kelly, D. J. & Poronnik, P. 2015 In : American Journal of Physiology - Renal Physiology. 308, 7, p. 784 - 792 9 p. Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance Sun, Y. B. Y., Qu, X., Howard, V., Dai, L., Jiang, X., Ren, Y., Fu, P., Puelles, V. G., Nikolic-Paterson, D. J., Caruana, G., Bertram, J. F., Sleeman, M. W. & Li, J. 2015 In : Kidney International. 88, 2, p. 286 - 298 13 p. Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat Ramessur, S., Tesch, G. H., Han, Y., Woodman, N., Mulley, W., Kanellis, J., Blease, K., Ma, F. & Nikolic-Paterson, D. J. 2015 In : International Journal of Experimental Pathology. 96, 1, p. 54 - 62 9 p.