Mathias, Rommel - Monash University - Department of Microbiology

研究领域

We study the molecular mechanisms of human cytomegalovirus (HCMV) using cutting-edge mass spectrometry. Human cytomegalovirus (HCMV) is a β-herpesvirus and a ubiquitous pathogen that infects over 60% of adults. HCMV infections are a significant cause of morbidity and mortality in immuno-compromised people, and can cause permanent hearing defects, vision loss, and mental retardation in newborn infants. Cells that are infected with HCMV undergo profound reorganization, and their cellular organelles are dramatically remodelled to sustain a structure known as the viral assembly complex (vAC). The vAC has been associated with packaging of the virus and extracellular release, however this process remains largely unknown. As part of the ‘Infection and Immunity' theme in the Biomedicine Discovery Institute, research in our lab studies HCMV infection from both host and viral perspectives. We aim to identify host organelles that are targeted by viral proteins, and characterize the molecular mechanisms of HCMV using a hybrid multidiscipline approach integrating virology, molecular biology, microscopy, genomics, proteomics, and bioinformatics.

近期论文

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Gopal S.K., Greening D.W., Hanssen E.G., Zhu H.J., Simpson R.J., and Mathias R.A. (2016) Oncogenic epithelial cell-derived exosomes containing Rac1 and PAK2 induce angiogenesis in recipient endothelial cells. Oncotarget. Mathias R.A., Greco T.M., and Cristea I.M. (2016) Identification of SIRT4 protein interactions: Uncovering candidate acyl-modified mitochondrial substrates and enzymatic regulators. Methods Mol. Biol. Gopal S.K., Greening D.W., Mathias R.A., Ji H., Rai A., Chen M., Zhu H.J., and Simpson R.J. (2015) YBX1/YB-1 induces partial EMT and tumourigenicity through secretion of angiogenic factors into the extracellular microenvironment. Oncotarget 6:13718-13730 Mathias R.A., Guise A.J., and Cristea I.M. (2015) Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease. Mol. Cell. Proteomics 14:456-470 Greening D.W., Gopal S.K., Mathias R.A., Liu L., Sheng J., Zhu H.J., and Simpson, R.J. (2015) Emerging roles of exosomes during epithelial-mesenchymal transition and cancer progression. Semin. Cell Dev. Biol. 40:60-71 Mathias R.A., Greco T.M., Oberstein A., Budayeva H.G., Chakrabarti R., Rowland E.A., Kang Y., Shenk T., and Cristea I.M. (2014) Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell 159:1615-1625 Guise A.J., Mathias R.A., Rowland E.A., Yu F., and Cristea I.M. (2014) Probing phosphorylation-dependent protein interactions within functional domains of histone deacetylase 5 (HDAC5). Proteomics 14:2156-2166 Tauro B.J., Mathias R.A., Greening D.W., Gopal S.K., Ji H., Kapp E.A., Coleman B.M., Hill A.F., Kusebauch U., Hallows J.L., Shteynberg D., Moritz R.L., Zhu H.J., and Simpson R.J. (2013) Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. Mol. Cell. Proteomics 12:2148-2159 Tauro B.J., Greening D.W., Mathias R.A., Mathivanan S., Ji H., and Simpson R.J. (2013) Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol. Cell. Proteomics 12:587-598