McGowan, Sheena - Monash University - Department of Microbiology

研究领域

The McGowan laboratory is interested in characterising novel molecular drug targets. The growing problem of drug resistance within the microbial world underlies the critical need to develop new treatments to prevent and control resistant infections. Therefore, the development of new therapeutic approaches for the treatment of microbial infections is a critically important goal. Our lab has a strong research focus in the design of novel anti-malarial drugs as well as other parasitic and bacterial diseases.

近期论文

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Mistry§, Drinkwater§, Ruggeri, Kannan Sivaraman, Loganathan, Fletcher, Drag, Paiardini, Avery, Scammells & McGowan (2014) "A Two-pronged Attack: Dual Inhibition of M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic acid-based Inhibitors" J. Med. Chem. doi.org/10.1021/jm501323a. § JOINT FIRST AUTHORS. Lim, Yang, Bankala, Kannan Sivaraman, Chandrashekaran, Kass, MacRaild, Devine, Debono, Anders, Scanlon, Scammells, Norton & McGowan "X-ray crystal structure of Apical Membrane Antigen 1 from Plasmodium falciparum FVO Biochemistry. doi.org/10.1021/bi5012089. Drinkwater, N. and McGowan, S. (2014) "From crystal to compound: structure-based antimalarial drug discovery". Biochem J In Press (accepted 22 April). FRONT COVER Wang, MacRaild, Mohanty, Mobli, Cowieson, McGowan, Anders, Simpson, Norton & Scanlon. (2014) "Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide" PlosONE (Accepted 3/9/14) Meyer, Aragao, Mudie, Caradoc-Davies, McGowan, Bertling, Groenewegen, Quenette, Bond, Buckle & Androulakis. (2014) "Operation of the Australian Store.Synchrotron for Macromolecular Crystallography" Acta Cryst Section D, Accepted 12/7/14 Gras, Byzia, Gilbert, McGowan, Drag, Silvestre, Niepceron, Lecaille, Lalmanach & Brossier (2014) "Aminopeptidase N1 (Et-ApN1), a M1 metalloprotease of the apicomplexan parasite Eimeria tenella participates in parasite development" Eukaryot Cell 13(7), 884-895.