Roujeinikova, Anna - Monash University - Department of Microbiology

研究领域

The research focus of my group is structural biology of virulence factors of the carcinogenic bacterium Helicobacter pylori. (I) H. pylori must be able to swim by means of its flagella in order to infect the human host and persist for years in the gastric mucosa. We study the mechanism of force generation in H. pylori flagellar motor and the structure and function of the key motility and chemotaxis proteins. (II) Development of gastric cancer in infected individuals is facilitated by exposure of gastric cells to H. pylori protein CagA. We investigate the mechanism of CagA-mediated gastric cell transformation. (III) The eradication rates achieved with the standard therapy have been declining and now fail in approximately 20%-30% of the patients, mainly due to antibiotic resistance. We investigate structure and function of the essential H. pylori proteins that have not yet experienced selective pressure in the clinical setting. The structural insights gained through this work will provide strategies for rational design of novel therapeutics.

近期论文

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Machuca MA, Liu YC, Beckham SA, Gunzburg MJ and Roujeinikova A (2016) The crystal structure of the tandem-PAS sensing domain of Campylobacter jejuni chemoreceptor Tlp1 suggests indirect mechanism of ligand recognition. J. Struct. Biol. 194, 205-213. • Modak JK, Rut W, Wijeyewickrema LC, Pike RN, Drag M and Roujeinikova A (2016) Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase. Biochimie 121, 60-71.