个人简介

Nanjing University, China - B.S. (1986) & M.S. (1989) University of Florida, Ph.D. (1995) University of California, Berkeley - Postdoc. Fellow (1995-1997) Lawrence Berkeley National Lab - Staff Scientist (1997-2001)

研究领域

Analytical Chemistry/Chemical Biology/Environmental Chemistry/Materials Chemistry

The research in our lab focuses on developing novel detection techniques for biological molecules, with an emphasis on “real-time” detecting methodologies. Our work involves design and synthesis of functional materials capable of effective optical or electrical signaling, and use of surface plasmon resonance (SPR) spectroscopy and imaging techniques for characterization and measurements. chengdesign2Biosensors are molecule-based devices that transduce a biochemical process or a binding event into a measurable signal. A typical biosensor consists of a receptor that defines specificity and a transducer that generates signals. Our biosensor research is directed at establishing effective signal transduction pathways through functionalization of supramolecular assemblies with cell surface constituents. Current research efforts are centered at membrane-based biosensors fabricated with supported lipid bilayer membranes. We are interested in design of robust membrane arrays, use of membranes for suppressing non-specific interactions in immunoassay, and detection of membrane-targeting bacterial toxins and other biomolecules. In addition, we employ microfabrication techniques to build sensor chips capable of self-calibration and signal amplification to enhance detection sensitivity and lower false positive response rates. Functional Biomaterials chengdesign3The ability to precisely control molecular arrangements developed in nanotechnology holds forth the promise of a completely new generation of advanced materials. We are interested in using these principles for design and fabrication of novel materials for analytical applications. The current systems consist of functional conjugated polymers of polydiacetylenes (PDA) and polythiophenes (PT). In addition to colorimetric detection employing the unique optical properties of the polymers, we also seek to develop new concepts that expand the applications into new territories. One good example for such an expansion is the development of "turn-on" fluorescent sensors with PDA assemblies. Bio-Interfaces To design effective biosensors, the nature of molecular interactions between the target and receptor molecules must be fully understood. We are interested in studying the affinity properties by developing new surface plasmon resonance spectroscopy and imaging techniques. SPR is a quantum optical-electrical phenomenon capable of sensitive and quantitative measurement of a broad spectrum of chemical and biological entities without the need of a label. Since the phenomenon of SPR is completely nonspecific, rational design of the sensing interface is critical. The analytical aspects of SPR bio-interface study include ultrasensitive detection of toxins, multiplexed array analysis, and signal amplification through various mechanisms. Coupling SPR with other analytical techniques for simultaneous quantification and identification is also being explored

近期论文

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Chen CY, Hinman SS, Duan J, Cheng Q*. "Nanoglassified, Optically-Active Monolayer Films of Gold Nanoparticles for in Situ Orthogonal Detection by Localized Surface Plasmon Resonance and Surface-Assisted Laser Desorption/Ionization-MS", Anal Chem. 2014, 86, 11942-5 Ghang YJ, Perez L, Morgan MA, Si F, Hamdy OM, Beecher CN, Larive CK, Julian RR, Zhong W, Cheng Q, Hooley RJ. "Anionic deep cavitands enable the adhesion of unmodified proteins at a membrane bilayer", Soft Matter 2014, 10, 9651-6. Ghang YJ, Lloyd JJ, Moehlig MP, Arguelles JK, Mettry M, Zhang X, Julian RR, Cheng Q, Hooley RJ. "Labeled protein recognition at a membrane bilayer interface by embedded synthetic receptors". Langmuir 2014, 30, 10161-6. Davis BW, Burris AJ, Niamnont N, Hare CD, Chen CY, Sukwattanasinitt M, Cheng Q*, "Dual-mode optical sensing of organic vapors and proteins with polydiacetylene (PDA)-embedded electrospun nanofibers", Langmuir 2014, 30, 9616-22. Ghang YJ, Schramm MP, Zhang F, Acey RA, David CN, Wilson EH, Wang Y, Cheng Q, Hooley RJ. "Selective cavitand-mediated endocytosis of targeted imaging agents into live cells", J. Am. Chem. Soc. 2013, 135, 7090-3. Li H, Chen CY, Wei X, Qiang W, Li Z, Cheng Q, Xu D. "Highly sensitive detection of proteins based on metal-enhanced fluorescence with novel silver nanostructures", Analytical Chemistry 2012, 84, 8656-62. Liu Y, Young MC, Moshe O, Cheng Q*, Hooley RJ*. "A Membrane-Bound Synthetic Receptor that Promotes Growth of a Polymeric Coating at the Bilayer-Water Interface", Angew Chem Int Ed. 2012, 51, 7748-51. Gao C, Lu Z, Liu Y, Zhang Q, Chi M, Cheng Q, Yin Y. "Highly stable silver nanoplates for surface plasmon resonance biosensing", Angew Chem Int Ed. 2012, 51, 5629-33. Ying Liu and Quan Cheng*. "Detection of membrane-binding proteins by surface plasmon resonance with an all-aqueous amplification scheme", Analytical Chemistry 2012, 84, 3179-86. Liu Y, Taira T, Young MC, Ajami D, Rebek J Jr*, Cheng Q*, Hooley RJ*. "Protein recognition by a self-assembled deep cavitand monolayer on a gold substrate", Langmuir 2012, 28, 1391-8. Matthew J. Linman, Hai Yu, Xi Chen and Quan Cheng*. "Surface Plasmon Resonance Imaging Analysis of Protein Binding to a Sialoside-Based Carbohydrate Microarray", in "Methods in Molecular Biology, Vol 808", Ed by Yann Chevolot, Humana Press, New York, 2012, pp183-194. Bryce W. Davis, Nakorn Niamnont, Robert Dillon, Christopher Bardeen, Mongkol Sukwattanasinitt*, and Quan Cheng*. "FRET detection of proteins using fluorescently doped electrospun nanofibers and pattern recognition", Langmuir 2011, 27, 6401-8. Matthew J. Linman, Abdennour Abbas and Quan Cheng*. "Etched Glass Microarrays with Differential Resonance for Enhanced Contrast and Sensitivity of SPR Imaging Analysis", Analytical Chemistry 2011, 83, 5936-43. Abdennour Abbas, Matthew J. Linman and Quan Cheng*. "Sensitivity Comparison of Surface Plasmon Resonance and Plasmon-Waveguide Resonance Biosensors", Sensors and Actuators B 2011 156, 169-175. Abdennour Abbas, Matthew J. Linman and Quan Cheng*. "Patterned Resonance Plasmonic Microarrays for High-Performance SPR Imaging", Analytical Chemistry 2011, 83, 3147-52. Hui Wang, Jicheng Duan and Quan Cheng*. "Photocatalytically Patterned TiO2 Arrays for On-Plate Selective Enrichment of Phosphopeptides and Direct MALDI MS Analysis", Analytical Chemistry 2011, 83, 1624–1631. Abdennour Abbas, Matthew J. Linman and Quan Cheng*. "New trends in instrumental design for surface plasmon resonance-based biosensors", Biosensors and Bioelectronics, 2011, 26, 1815-1824. Jicheng Duan, Hui Wang and Quan Cheng*. "On-Plate Desalting and SALDI-MS Analysis of Peptides with Hydrophobic Silicate Nanofilms on a Gold Substrate", Analytical Chemistry 2010, 82, 9211-9220. Matthew J. Linman, Abdennour Abbas and Quan Cheng*. "Interface Design and Multiplexed Analysis with Surface Plasmon Resonance (SPR) Spectroscopy and SPR Imaging", Analyst, 2010, 135, 2759-2767. Ying Liu, Puhong Liao, Quan Cheng* and Richard J. Hooley*. "Protein and Small Molecule Recognition Properties of Deep Cavitands in a Supported Lipid Membrane Determined by Calcination-Enhanced SPR Spectroscopy", J. Am. Chem. Soc. 2010, 132, 10383-10390.