杨巍 - 浙江大学 - 基础医学院

个人简介

1993年考入杭州大学生命科学学院，1997年毕业后留校团委，担任社会实践部部长。2001年进入浙江大学医学院攻读生理学硕士，后于2005年继续攻读神经生物学博士，2008年获博士学位，之后留在浙江大学神经科学研究所任教，于2009-2011期间年获得英国皇家学会牛顿国际奖学金资助，赴英国利兹大学进行为期两年的学术访问，2011年晋升为副教授，2014年获得国家留学基金委访问学者资助，赴美国加州大学戴维斯分校进行学术交流，于2015年晋升为浙江大学教授。

研究领域

神经生物学、生物物理学、分子药理学杨巍教授长期来致力于Ca2+通透的配体门控离子通道（包括 NMDA 受体， TRPM2 和 TRPV1等）结构功能研究，以及它们在神经系统中的生理和病理功能，并针对这些靶点开发脑中风等神经系统疾病的治疗药物

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Zhang H, Yu P, Lin H, Jin Z, Zhao S, Zhang Y, Xu Q, Jin H, Liu Z, Yang W, Zhang L. The Discovery of Novel ACA Derivatives as Specific TRPM2 Inhibitors that Reduce Ischemic Injury Both In Vitro and In Viv[J]. Journal of medicinal chemistry, 2021. Wang M#, Li J#, Dong S, Cai X, Simaiti A, Yang X, Zhu X, Luo J, Jiang L, Du B*, Yu P*, Yang W*. Silica nanoparticles induce lung inflammation in mice via ROS/PARP/TRPM2 signaling-mediated lysosome impairment and autophagy dysfunction. Particle and Fibre Toxicology, 2020,17(23). Xu L, Han Y, Chen X, Aierken A, Wen H, Zheng W, Wang H, Lu X, Zhao Z, Ma C, Liang P, Yang W*, Yang S*, Yang F*. Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel. Nature communications, 2020,11(1). Zhu F#, Cai X#, Yang X, He J, Wang C, Wang M, Simaiti A, Yang W, Zhu X, Yu P*. TRPM2 expression levels are associated with histological grading in patients with tongue squamous cell carcinoma. Mol Med Rep. 2020. 22: 3566-3574. Yu P, Cai X, Liang Y, Wang M, Yang W*. Roles of NAD+ and Its Metabolites Regulated Calcium Channels in Cancer. Molecules, 2020, 25(20):4826 Zhang H, Zhao S, Yu J, Yang W, Liu Z*, Zhang L*. Medicinal chemistry perspective of TRPM2 channel inhibitors: where we are and where we might be heading?. Drug Discov Today. 2020. 25(12):2326-2334. Yu P, Liu Z, Yu X, Ye P, Liu H, Xue X, Yang L, Li Z, Wu Y, Fang C, Zhao Y, Yang F, Luo J, Jiang L, Zhang L, Zhang L, Yang W*. Direct Gating of the TRPM2 Channel by cADPR via Specific Interactions with the ADPR Binding Pocket[J]. Cell Reports, 2019, 27(12): 3684-3695. e4. Yu X, Feng Z, Cai Z, Jiang M, Xue D, Zhu L, Zhang Y, Liu J, Que B, Yang W, Xi W, Zhang D*, Qian J*, Li G*. Deciphering of cerebrovasculatures via ICG-assisted NIR-II fluorescence microscopy[J]. Journal of Materials Chemistry B, 2019. Feng Z#, Yu X#, Jiang M, Zhu L, Zhang Y, Yang W, Xi W, Li G, Qian J*. Excretable IR-820 for in vivo NIR-II fluorescence cerebrovascular imaging and photothermal therapy of subcutaneous tumor[J]. Theranostics, 2019, 9(19): 5706. Cen Z, Chen Y, Yang D, Zhu Q, Chen S, Chen X, Wang B, Xie F, Ouyang Z, Jiang Z, Fu A, Hu B, Yin H, Qiu X, Yu F, Du X, Hao W, Liu Y, Wang H, Wang L, Yu X, Xiao Y, Liu C, Xiao J, Zhou Y, Yang W, Zhang B, Luo W*. Intronic (TTTGA) n insertion in SAMD12 also causes familial cortical myoclonic tremor with epilepsy[J]. Movement Disorders, 2019, 34(10): 1571-1576. Liu S#, Chang S#, Han B#, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J*, Delpire E*, Ye S*, Bai X*, Guo J*. Cryo-EM structures of the human cation-chloride cotransporter KCC1. Science, 2019, 366(6464): 505-508. Luo Y, Yu X, Ma C, Yang F, Yang W*. Effects of calcium-binding sites in the S2–S3 loop on human and Nematostella vectensis TRPM2 channel gating processes. Journal of Zhejiang University-SCIENCE B, 2019, 20(12):972-982. Luo X, Li M, Zhan K, Yang W, Zhang L, Wang K*, Yu P*, Zhang L*. Selective inhibition of TRPM 2 channel by two novel synthesized ADPR analogues[J]. Chemical biology & drug design, 2018, 91(2): 552-566. Zhang H, Liu H, Luo X, Wang Y, Liu Y, Jin H, Liu Z, Yang W, Yu P*, Zhang L*, Zhang L.Design, synthesis and biological activities of 2, 3-dihydroquinazolin-4 (1H)-one derivatives as TRPM2 inhibitors[J]. European journal of medicinal chemistry, 2018. Jiang LH*, Li X, Syed Mortadza SA, Lovatt M, Yang W. The TRPM2 channel nexus from oxidative damage to Alzheimer’s pathologies: An emerging novel intervention target for age-related dementia[J]. Ageing research reviews, 2018, 47: 67-79. Yang F, Xiao X, Lee BH, Vu S, Yang W, Yarov-Yarovoy V, Zheng J. The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel. Nat Commun, 2018 Jul 23;9(1):2879. Luo Y, Yu X, Ma C, Luo J, Yang W*. Identification of a Novel EF-Loop in the N-terminus of TRPM2 Channel Involved in Calcium Sensitivity[J]. Frontiers in pharmacology, 2018, 9. Wang J#, Lv X#, Wu Y, Xu T, Jiao M, Yang R, Li X, Chen M, Yan Y, Chen C, Dong W, Yang W, Zhuo M, Chen T*, Luo J*, Qiu S*. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons[J]. Nature communications, 2018, 9(1): 2267. Yu P, Xue X, Zhang J, Hu X, Wu Y, Jiang LH, Jin H, Luo J, Zhang L, Liu Z*, Yang W*. Identification of the ADPR binding pocket in the NUDT9 homology domain of TRPM2[J]. The Journal of general physiology, 2017, 149(2): 219-235. Jiang Q, Gao Y, Wang C, Tao RR, Wu Y, Zhan K, Liao MH, Lu N, Lu YM, Wilcox CS, Luo J, Jiang LH*, Yang W*, Han F*. Nitration of TRPM2 as a Molecular Switch Induces Autophagy during Brain Pericyte Injury[J]. Antioxidants & Redox Signaling, 2017.