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个人简介

教育背景 2003-09--2010-07 中科院大连化物所 硕博连读 1999-09--2003-07 安徽大学 学士 工作经历 2015年10月-至今 中科院大连化物所单细胞分析研究组组长 2014年10月—2015年9月 耶鲁大学生物医学工程系Associate Research Scientist 2010年10月—2014年9月 耶鲁大学生物医学工程系Postdoctoral Associate

研究领域

1. 高通量同一单细胞多时间点动态分析以及多种不同参数的分析方法 2. 高通量智能数字液滴微反应器系统用于单细胞操控 3. 肿瘤的体外、个体化单细胞分析及其临床应用 4. 基于微流控芯片的快速、高灵敏分析

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Meimei Liu, Meihua Jin, Linmei Li, Yahui Ji, Fengjiao Zhu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yao Lu* PDMS Microwell Stencil Based Multiplexed Single‐Cell Secretion Analysis. Proteomics, 2020, 1900231. Yahui Ji, Dongyuan Qi, Linmei Li, Haoran Su, Xiaojie Li, Yong Luo, Bo Sun, Fuyin Zhang, Bingcheng Lin, Tingjiao Liu*, Yao Lu* Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion. PNAS, 2019, 116 (13) 5979-5984. Zhuo Chen#, Yao Lu#*, Kerou Zhang, Yang Xiao, Jun Lu, Rong Fan* Multiplexed, sequential secretion analysis of the same single cells reveals distinct effector response dynamics dependent on the initial basal state. Advanced Science, 2019, 6, 1801361 (Highlighted as Inside Cover). Jun Ma#, Shiqiang Yan#, Chunyue Miao, Linmei Li, Weiwei Shi, Xianming Liu, Yong Luo, Tingjiao Liu, Bingcheng Lin, Wenming Wu,*, Yao Lu* Paper Microfluidics for Cell Analysis. Advanced Healthcare Materials, 2019, 8, 1801084. Ruihan Bai, Linmei Li, Meimei Liu, Shiqiang Yan, Chunyue Miao, Ruijun Li, Yong Luo, Tingjiao Liu, Bingcheng Lin, Yibing Ji*, and Yao Lu* Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical Chemistry, 2018, 90 (9), pp 5825–5832. Linmei Li, Shiqiang Yan, Bingcheng Lin, Qihui Shi*, Yao Lu* Single-Cell Proteomics for Cancer Immunotherapy, Advances in Cancer Research, 2018. Yueyang Qu, Fan An, Yong Luo*, Yao Lu, Tingjiao Liu, Weijie Zhao, Bingcheng Lin. A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity. Biomaterials, 2018, 155, 41-53. Yao Lu, Liu Yang, Wei Wei*, Qihui Shi* Microchip-Based Single-Cell Functional Proteomics for BiomedicalApplications. Lab on a Chip, 2017, Mar 29;17(7):1250-1263. Shimeng Fang, Hongzhu Tian, Xiancheng Li, Dong Jin, Xiaojie Li, Jing Kong, Chun Yang, Xuesong Yang, Yao Lu, Yong Luo, Bingcheng Lin, Weidong Niu*, Tingjiao Liu* Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification. PLoS One. 2017 Apr 3;12(4):e0175050. doi: 10.1371/journal.pone.0175050. eCollection 2017. Kun Zou, Zhigang Gao, Quanfeng Deng, Yong Luo, Lijuan Zou, Yao Lu, Weijie Zhao and Bingcheng Lin Picomolar detection of carcinoembryonic antigen in whole blood using microfluidics and surface-enhanced Raman spectroscopy. Electrophoresis, 2016, 37(5-6):786-9. Qiong Xue†, Yao Lu†, Markus R. Eisele, Endah S. Sulistijo, Nafeesa Khan, Rong Fan*, and Kathryn Miller-Jensen* Analysis of single cell secretion reveals a role for paracrine signaling in coordinating macrophage response to TLR4 stimulation. Science Signaling, 2015, 8(381), ra59. Yao Lu†, Qiong Xue†, Markus Eisele, Endah Sulistijo, Kara Brower, Lin Han, El-ad David Amir, Dana Pe’er, Kathryn Miller-Jensen* & Rong Fan* Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands. PNAS, 2015, 112 (7), E607-E615. Yao Lu†, Jonathan J. Chen†, Luye Mu, Qiong Xue, Yu Wu, Pei-Hsun Wu, Jie Li, Alexander O. Vortmeyer, Kathryn Miller-Jensen, Denis Wirtz, and Rong Fan* High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity. Analytical Chemistry 2013, 85 (4), 2548–2556 Yao Lu, Bingcheng Lin*, Jianhua Qin*. Patterned Paper as a Low-cost, Flexible Substrate for Rapid Prototyping PDMS Microdevices via “liquid molding” . Analytical Chemistry 2011, 83 (5), 1830–1835 Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Fabrication And Characterization of Paper Based Microfluidics Prepared in Nitrocellulose Membrane By Wax Printing. Analytical Chemistry 2010, 82, 329–335 Yao Lu, Weiwei Shi, Lei Jiang, Jianhua Qin*, Bingcheng Lin*. Rapid prototyping of paper-based microfluidics with wax for low-cost, portable bioassay . Electrophoresis 2009, 30, 1497–1500 Yao Lu, Weiwei Shi, Jianhua Qin*, Bingcheng Lin*. Low cost, portable detection of gold nanoparticle-labeled microfluidic immunoassay with camera cell phone. Electrophoresis 2009, 30, 579–582 (selected by editor as Fast Track) Lei Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Bingcheng Lin*. Mini-electrochemical Detector for Microchip Electrophoresis. Lab Chip 2005, 5(9), 930-934 Lei Jiang, Xuening Jiang, Yao Lu, Zhongpeng Dai, Minhao Xie, Jianhua Qin*, Bingcheng Lin*. Development of a universal serial bus-powered mini-high-voltage power supply for microchip electrophoresis. Electrophoresis 2007, 28(8), 1259–1264. Weiwei Shi, Hui Wen, Yao Lu, Yang Shi, Bingcheng Lin*,Jianhua Qin* Droplet Microfluidics for Characterizing the Neurotoxin-induced Responses in Individual Caenorhabditis elegans. Lab Chip, 2010, 10, 2855 – 2863

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