Prescott, Mark - Monash University - Department of Biochemistry and Molecular Biology

研究领域

The laboratory has a strong research focus on the development and application of novel GFP-like proteins. We use a range of biophysical techniques including X-crystallography and spectroscopy to investigate how the structure of these intriguing proteins determines the wide range of optical characteristics, one of which is their colour. GFP technology is an indispensible tool for use in molecular cell biology research.

近期论文

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Ultramarine, a chromoprotein acceptor for Förster resonance energy transfer' Anne Pettikiriarachchi, Lan Gong, Matthew A. Perugini, Rodney J. Devenish and Mark Prescott PloS One (2012) 7 (7):e41028. ‘HcRed, a genetically encoded fluorescent binary cross-linking agent for cross-linking of mitochondrial ATP synthase in Saccharomyces cerevisiae'.Lan Gong, Georg Ramm, Rodney J. Devenish and Mark Prescott (2012) PLoS One 7, (4) e35095. "Autophagy in human embryonic stem cells". Tra, T., Gong, L., Kao, L.P., Li, X.L., Grandela, C., Devenish, R.J., Wolvetang, E. & Prescott M. (2011) PLoS One. 6 (doi:10.1371/journal.pone.0027485). "Autophagy as a macrophage response to bacterial infection" Lan Gong, Rodney J. Devenish and Mark Prescott (2012) IUBMB Life doi: 10.1002/iub.1070 "Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines". Cullinane, M., Gong, L., Li, X., Lazar-Adler, N., Tra, T., Wolvetang, E., Prescott, M. Boyce, J.D., Devenish, R.J. and Adler, B. (2008) Autophagy. 4, 744-53. "A Fluorescence Microscopy Assay for Monitoring Mitophagy or Nucleophagy in the Yeast Saccharomyces cerevisiae" Mijaljica D, Prescott M and Devenish RJ Journal Vis Exp (2011) Mijaljica, D., Prescott, M. & Devenish, R.J. "Hungry for Power: Elimination of mitochondria by mitophagy", May, A., Prescott, M. Australian Biochemist (2011), 42 (2), Australia, pp. 4-7. "Receptor protein complexes are in control of autophagy" Dalibor Mijaljica, Taras Nazarko, John Brumell, Wei-Pang Huang, Masaaki Komatsu, Mark Prescott, Anne Simonsen, Ai Yamamoto, Hong Zhang, Daniel Klionsky and Rodney Devenish. (2012) Autophagy. Accepted July 3rd 2012. "The 2.2 a crystal structure of a pocilloporin pigment reveals a non-planar chromophore conformation". Prescott, M., Ling, M., Beddoe, T., Oakley, A.J., Dove, S., Hoegh-Guldberg, O., Devenish, R.J. & Rossjohn, J. (2003) Structure 11, 275-284. "The 2.0 Å crystal structure of eqFP611, a far-red fluorescent protein from the sea anemone Entacmaea quadricolor." Petersen, J., Wilmann, P.G., Beddoe, T, Aaron J. Oakley, A.J. Devenish, R.J. Prescott, M. & Rossjohn, J. (2005) J. Biol Chem. 278, 44626-31. "The 2.1 A crystal structure of the far-red fluorescent protein HcRed: inherent conformational flexibility of the chromophore" Wilmann, P.G., Petersen, J., Pettikiriarachichi, A., Buckle, A. M., Smith, S. C., Olsen, S., Devenish, R.J., Prescott, M. & Rossjohn, J. (2005) J. Mol. Biol. 349, 223-37. "Variations on the GFP chromophore: A polypeptide fragmentation within the chromophore revealed in the 2.1 Å crystal structure of a non-fluorescent chromoprotein from Anemonia sulcata" Wilmann, P.G., Petersen, J., Devenish, R.J., Prescott, M. & Rossjohn, J. (2005) J. Biol. Chem. 280, 2401-2404.