Wilce, Jackie - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Research in the Wilce lab focuses on the study of protein-peptide and protein-oligonucleotide interactions that occur in human cells to control gene expression, cell growth and cell proliferation.

近期论文

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Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC and Wilce JA. Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target. J Med Chem. 2015 Sep 11. [Epub ahead of print] Gunzburg MJ, Sivakumaran A, Pendini NR, Yoon JH, Gorospe M, Wilce MC and Wilce JA. Cooperative interplay of let-7 mimic and HuR with MYC RNA. Cell Cycle. 2015 Sep 2;14(17):2729-33. Waris S, Wilce MC and Wilce JA. RNA recognition and stress granule formation by TIA proteins. Int J Mol Sci. 2014 Dec 16;15(12):23377-88. Cruz-Gallardo I, Aroca Á, Gunzburg MJ, Sivakumaran A, Yoon JH, Angulo J, Persson C, Gorospe M, Karlsson BG, Wilce JA and Díaz-Moreno I. The binding of TIA-1 to RNA C-rich sequences is driven by its C-terminal RRM domain. RNA Biol. 2014;11(6):766-76. Ambaye ND, Gunzburg MJ, Traore DA, Del Borgo MP, Perlmutter P, Wilce MC and Wilce JA. Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist. Acta Crystallogr F Struct Biol Commun. 2014 Feb;70(Pt 2):182-6. Lim RC, Price JT and Wilce JA. Context-dependent role of Grb7 in HER2+ve and triple-negative breast cancer cell lines. Breast Cancer Res Treat. 2014 Feb;143(3):593-603. Kim HS, Headey SJ, Yoga YM, Scanlon MJ, Gorospe M, Wilce MC and Wilce JA. Distinct binding properties of TIAR RRMs and linker region. RNA Biol. 2013 Apr;10(4):579-89.