Stone, Martin - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Research Interests: Chemokine Receptors in Inflammation and Infection Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue. However, excessive leukocyte recruitment can lead to degradation of healthy tissue, i.e. inflammatory disease. Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leucocytes. A detailed understanding of chemokine-receptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases.

近期论文

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Tan, J.H.Y., Canals, M., Ludeman, J.P., Wedderburn, J., Boston, C., Butler, S.J., Carrick, A.M., Parody, T.R., Taleski, D., Christopoulos, A., Payne, R.J. and Stone, M.J. Design and Receptor Interactions of Obligate Dimeric Mutant of Chemokine Monocyte Chemoattractant Protein-1 (MCP-1). J. Biol. Chem. (2012) 287, 14692-14702. Barter, E.F. and Stone, M.J. Synergistic Interactions between Chemokine Receptor Elements in Recognition of Interleukin-8 by Soluble Receptor Mimics. Biochemistry (2012), 51, 1322-1331. Taleski, D., Butler, S.J., Stone, M.J, and Payne, R.J. Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides. Chem. Asian J. (2011) 6, 1316-1320. Zhu, J.Z., Millard, C.J., Ludeman, J.P., Simpson, L.S., Clayton, D.J., Payne, R.J., Widlanski, T.S., and Stone, M.J. Tyrosine Sulfation Influences the Chemokine-Binding Selectivity of Peptides Derived from Chemokine Receptor CCR3. Biochemistry (2011) 50, 1524-1534. Stone, M.J., Chuang, S., Hou, X., Shoham, M., and Zhu, J.Z. Tyrosine Sulfation: An Increasingly Recognised Posttranslational Modification of Secreted Proteins. New Biotechnology (2009) 25, 299-317. Simpson, L.S., Zhu, J.Z., Widlanski, T.S., and Stone, M.J. Regulation of Chemokine Recognition by Site-Specific Tyrosine Sulfation of Receptor Peptides Chemistry & Biology (2009) 16, 153-161. Richer, S.M., Stewart, N.K., Tomaszewski, J.W., Stone, M.J., and Oakley, M.G. NMR investigation of the binding between human profilin I and inositol-1,4,5-triphosphate (IP3), the soluble headgroup of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2). Biochemistry (2008) 47, 13455-13462. Jarymowycz, V.A. and Stone, M.J. Remote Changes in the Dynamics of the Phosphotyrosine-Binding Domain of Insulin Receptor Substrate-1 Induced by Phosphopeptide Binding. Biochemistry (2008) 47, 13371-13382. Datta-Mannan, A. and Stone, M.J. Chemokine Binding Specificity of Soluble Chemokine Receptor Analogues: Identification of Interacting Elements by Chimera Complementation. Biochemistry (2004) 43, 14602-14611 Mayer, M.R., Parody, T.R., Datta-Mannan, A., and Stone, M.J. Specificity Determinants for Chemokine Recognition Identified Using Eotaxin-MCP-1 Chimeras. FEBS Lett. (2004) 571, 166-170. Parody, T.R. and Stone, M.J. Activation, and Antagonism of CC Chemokine Receptors CCR2 and CCR3 in Chinese Hamster Ovary Cells. Cytokine (2004) 27, 38-48.