Smyth, Ian - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Our group studies how the embryo develops with a view to understanding the developmental basis for congenital diseases and those caused by a compromised fetal environment. In particular we are interested in understanding the developmental mechanism known as "branching morphogenesis", which is employed by a large number of organs to establish the tissue architecture required to facilitate exchange of nutrients, gases or waste in the adult organ. The branched airways of the lung and the urine collecting system of the kidney are examples of the end products of this remarkable process. By accurately quantifying how this happens in model organisms we aim to determine, in an appropriately rigorous manner, how genetic changes and environmental factors can shape organ structure. This is important for understanding the developmental origins of congenital diseases and in assessing whether and how the "normal" variations observed in the structure of organs between different individuals are influenced by their experiences and exposures as an embryo.

近期论文

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Cottle DL, Ursino GM, Ip SC, Jones LK, Ditommaso T, Hacking DF, Mangan NE, Mellett NA, Henley KJ, Sviridov D, Nold-Petry CA, Nold MF, Meikle PJ, Kile BT, Smyth IM (2015). Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis. Human Molecular Genetics. Jan 15;24(2):436-49. Plotnikova OV, Seo S, Cottle D, Conduit S, Hakim S, Dyson JM, Mitchell C, Smyth I (2015). INPP5E interacts with AURKA, linking phosphoinositide signalling to primary cilium stability. Journal of Cell Science. Jan 15;128(2):364-72. Combes AN*, Short KM*, Lefevre J*, Hamilton NA, Little MH^, Smyth IM^ (2014). An integrated pipeline for the multidimensional analysis of branching morphogenesis. Nature Protocols. Dec;9(12):2859-79. (* joint first, ^joint communicating). DiTommaso T, Jones LK, Cottle DL; The WTSI Mouse Genetics Program, Gerdin AK, Vancollie VE, Watt FM, Ramirez-Solis R, Bradley A, Steel KP, Sundberg JP, White JK, Smyth IM (2014) Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse. PLoS Genetics. Oct 23;10(10): e1004705. DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM. (2014) Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier. PLoS Genetics. Oct 23;10(10):e1004706. Short KM*, Combes AN*, Lefevre J, Ju AL, Georgas KM, Lamberton T, Cairncross O, Rumballe BA, McMahon AP, Hamilton NA, Smyth IM*, Little MH* (2014) Global quantification of tissue dynamics in the developing mouse kidney. Developmental Cell. Apr 28th 29(15). Fu Y, Mukhamedova N, Ip S, D'Souza W, Henley KJ, DiTommaso T, Kesani R, Ditiatkovski M, Jones L, Lane RM, Jennings G, Smyth IM, Kile BT, Sviridov D. (2013) ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metabolism. 18 2 225-238. Wiradjaja F, Cottle DL, Jones L, Smyth I. Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice. (2013) Disease Models and Mechanisms. 6(6) 1426-1433.