Cole, Timothy - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Associate Professor Cole's main research interests are the developmental roles of the adrenal steroid hormones that act through nuclear receptors, particularly related to respiratory development and premature babies. Other interests include the use of synthetic steroids to treat a range of inflammatory, respiratory and metabolic diseases. His laboratory has published extensively on the role of these steroid signaling pathways in various systems in the body.

近期论文

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Velkoska E, Cole T.J., Dean RG, Burrell LM, Morris MJ. (2008) Early undernutrition leads to long-lasting reductions in body weight and adiposity whereas increased intake increases cardiac fibrosis in male rats. J Nutr. 138(9):1622-7. Gong H, Jarzynka MJ, Cole T.J., Lee JH, Wada T, Zhang B, Gao J, Song W-C, DeFranco DB, Cheng Y-C, and Xie W. (2008) Glucocorticoids Antagonize Estrogens By Glucocorticoid Receptor-Mediated Activation Of Estrogen Sulfotransferase. Cancer Res. 68:7386-93 Wallace, M.J., Probyn, M.E., Crossley, K., Zahra, V.A., Cole, T.J., Davis, P.J.G., Morley, C.J. and Hooper S.B. (2009) Potential mediators of ventilation-induced lung injury in very preterm lambs. Pediatric Res 10, 19-25 Firsova A., Hyakumura T., Cole T.J., Mollard R. (2009) Epithelial-Mesenchymal Interactions during Lung Development and their Potential Relevance to Lung Repair. Book Chapter: Stem Cell Research and Therapy, Ed: J. Polak, Ch 3. Imperial College Press (London) Velkoska E., Warner F.J., Cole T.J., Smith I and Morris M.J. (2010) Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat. Nutr. Metab. Cardiovasc. 20, 49-55 Wong, S., Tan K.,, Carey K.T., Fukushima A., Tiganis T., and Cole T.J. (2010) Glucocorticoids Stimulate Hepatic and Renal Catecholamine Inactivation by Direct Rapid Induction of the Dopamine Sulfotransferase Sult1d1. Endocrinology 151, 185-194 Zhang, Y., Schyvens C.V, Cole T.J., McKenzie K.U.S., Vickers J.J. and Whitworth J.A. The glucocorticoid receptor is required for experimental adrenocorticotrophic hormone-induced hypertension in mice. Clin. Exp. Pharm. and Physiol. (2010) 37, 1044-1048 Jurado S., Smyth I., van Denderen B., Tenis N., Hammet A., Hewitt K., Hg, J.-L., McNees C.J., Kozlov S.V., Oka H., Kobayashi M., Conlan L.A., Cole T.J., Yamamoto K.-I., Taniguchi Y., Takeda S., Lavin M.F. and Heierhorst J. Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis. (2010) Plos Genetics 6, 1-13 Bird A.D, Flecknoe S.J., Tan K.H., Olsson P.F., Antony N., Mantamadiotis T., Hooper S.B. and Cole T.J. (2011) cAMP Response Element Binding Protein Is Required for Differentiation of Respiratory Epithelium during Murine Development. Plos One 6, 1-15 McDougall A.R.A, Hooper S.B., Zahra V.A., Sozo F., Lo C.Y., Cole T.J., Doran T. And Wallace M.J. (2011) The oncogene Trop2 regulates fetal lung cell proliferation. Am. J. Physiol. Lung Cell Mol. Physiol. 301: L478-489