Buckle, Ashley - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Our research is aimed at understanding how the structure and dynamics of proteins dictates their function.

近期论文

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Schmidberger JS, Bate MA, Reboul CF, Androulakis SG, Phan JMN, Whisstock JC, Goscinski WJ, Abramson A, and Buckle AM (2010) MrGrid: A Portable Grid Based Molecular Replacement Pipeline. PLoS One. Apr 6;5(4):e10049. Konagurthu AS, Reboul CF, Schmidberger JS, Irving, JA, Lesk AM, Stuckey PJ, Whisstock JC, and Buckle AM (2010) MUSTANG-MR Structural Sieving Server: Applications in Protein Structural Analysis and Crystallography. PLoS One. Apr 6;5(4):e10048. Fenalti G and Buckle AM (2009) Structural Biology of the GAD Autoantigen. Autoimmunity Reviews 9(3):148-52. Epub 2009 May 22. Swedberg JE, Nigon LV, Reid JC, de Veer SJ, Walpole CM, Stephens CR, Walsh TP, Takayama TK, Hooper JD, Clements JA, Buckle AM & Harris, JM. (2009) Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chemistry & Biology, 16, 633-43. FischerK,Langendorf CG, Irving JA, Reynolds S, Willis C, Beckham S, Law RHP, Yang S, Bashtannyk-Puhalovich TA, McGowan S, Whisstock JC, PikeRN, KempDJ, and Buckle AM (2009) Structural Mechanisms of Inactivation in Scabies Mite Serine Protease Paralogues. J. Mol. Biol. 390(4):635-45. Arafat Y, Fenalti G, WhisstockJC, MackayIR, Garcia de la BandaM, RowleyMJ and Buckle AM (2009) Structural Determinants of GAD Antigenicity. Molecular Immunology, 47(2-3):493-505 KaisermanD, BuckleAM, DammePV, IrvingJA, LawRHP, MatthewsAY, Bashtannyk-PuhalovichT, LangendorfCG, ThompsonVandekerckhoveJ, GevaertK, WhisstockJC, BirdPI. (2009) >The structure of granzyme C reveals an unusual mechanism of protease auto-inhibition. Proc. Natl. Acad. Sci. USA 106, 5587-92. McGowan S, Porter CJ, Lowther J, Stack CM, Golding SJ, Skinner-Adams TS, Trenholme KR, Teuscher F, Donnelly SM, Grembecka J, Mucha A, Kafarski P, Degori R, Buckle AM, Gardiner DL, Whisstock JC, Dalton JP. (2009) Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase. Proc. Natl. Acad. Sci. USA. 106, 2537-42. AndroulakisS, SchmidbergerJ, BateM, DeGoriR, BeitzA, KeongC, CameronR, McGowanS, PorterCJ, Harrison A, Hunter J, MartinJL, KobeB, DobsonRCJ, ParkerMW, WhisstockJC, GrayJ, TreloarA, GroenewegenD, Dickson Nand Buckle AM(2008) Federated repositories of X-ray diffraction images. Acta Crystallogr D Biol Crystallogr. 64, 810-814 Zhang Q, Law RH, Bottomley SP, Whisstock JC and Buckle AM. (2008) A structural basis for loop C-sheet polymerisation in serpins. J. Mol. Biol. 376, 1348-59.